======= VSX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VSX1
  * **<color #00a2e8>Official Name</color>**: visual system homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=30813|30813]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZR4|Q9NZR4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VSX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VSX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605020|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene contains a paired-like homeodomain and binds to the core of the locus control region of the red/green visual pigment gene cluster. The encoded protein may regulate expression of the cone opsin genes early in development. Mutations in this gene can cause posterior polymorphous corneal dystrophy and keratoconus. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retinal bipolar neuron differentiation|
|neuron maturation|
|retina morphogenesis in camera-type eye|
|neural retina development|
|camera-type eye morphogenesis|
|anatomical structure maturation|
|retina development in camera-type eye|
|eye morphogenesis|
|cell maturation|
|transcription regulatory region DNA binding|
|visual perception|
|sensory perception of light stimulus|
|developmental maturation|
|sensory organ morphogenesis|
|camera-type eye development|
|eye development|
|visual system development|
|sensory system development|
|chromatin binding|
|sequence-specific DNA binding|
|cellular component|
|sensory organ development|
|DNA-binding transcription factor activity|
|neuron development|
|animal organ morphogenesis|
|sensory perception|
|neuron differentiation|
|nervous system process|
|generation of neurons|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|cell development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15135
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VSX1 Expression in NALM6 Cells: -1.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>