======= VTI1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VTI1B
  * **<color #00a2e8>Official Name</color>**: vesicle transport through interaction with t-SNAREs 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10490|10490]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UEU0|Q9UEU0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VTI1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VTI1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603207|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. {ECO:0000269|PubMed:23217709}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-SNARE|
|V-SNARE C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vesicle fusion with Golgi apparatus|
|chloride channel inhibitor activity|
|Golgi to vacuole transport|
|SNAP receptor activity|
|autophagosome maturation|
|intra-Golgi vesicle-mediated transport|
|protein targeting to vacuole|
|vesicle docking involved in exocytosis|
|establishment of protein localization to vacuole|
|SNARE complex|
|ER to Golgi transport vesicle membrane|
|protein localization to vacuole|
|vesicle docking|
|SNARE binding|
|platelet alpha granule lumen|
|exocytic process|
|vesicle fusion|
|organelle membrane fusion|
|recycling endosome membrane|
|retrograde transport, endosome to Golgi|
|regulation of protein localization to plasma membrane|
|organelle fusion|
|post-Golgi vesicle-mediated transport|
|regulation of protein localization to cell periphery|
|recycling endosome|
|late endosome membrane|
|synaptic vesicle|
|platelet degranulation|
|membrane fusion|
|vacuolar transport|
|vesicle|
|cytosolic transport|
|early endosome membrane|
|macroautophagy|
|organelle localization by membrane tethering|
|membrane docking|
|regulation of protein localization to membrane|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|endosomal transport|
|protein-containing complex disassembly|
|autophagy|
|process utilizing autophagic mechanism|
|lysosomal membrane|
|vesicle organization|
|protein targeting|
|neuronal cell body|
|Golgi vesicle transport|
|cellular component disassembly|
|establishment of protein localization to organelle|
|regulation of cellular protein localization|
|organelle localization|
|intracellular membrane-bounded organelle|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|protein localization to organelle|
|exocytosis|
|membrane organization|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|Golgi apparatus|
|intracellular protein transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|secretion|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.93|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13177
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VTI1B Expression in NALM6 Cells: 5.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>