======= WBSCR16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RCC1L
  * **<color #00a2e8>Official Name</color>**: RCC1 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81554|81554]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96I51|Q96I51]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WBSCR16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WBSCR16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620739|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RCC1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial membrane fusion|
|positive regulation of mitochondrial translation|
|regulation of mitochondrial translation|
|regulation of mitochondrial gene expression|
|rRNA binding|
|organelle membrane fusion|
|organelle fusion|
|mitochondrial membrane|
|guanyl-nucleotide exchange factor activity|
|positive regulation of translation|
|mitochondrial membrane organization|
|membrane fusion|
|positive regulation of cellular amide metabolic process|
|regulation of translation|
|GTP binding|
|mitochondrial inner membrane|
|regulation of cellular amide metabolic process|
|mitochondrion organization|
|posttranscriptional regulation of gene expression|
|membrane organization|
|RNA binding|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp331|A-769662 20μM R07 exp331]]|-2.51|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.41|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-2.41|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-2.35|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-2.28|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.98|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-1.95|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.86|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.84|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.81|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.71|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.7|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.76|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.78|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.79|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.88|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.9|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.9|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.9|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.01|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.02|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.12|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.29|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.34|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.4|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.93|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|3.25|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.681|
|[[:human genes:d:dap3|DAP3]]|0.667|
|[[:human genes:m:mrps6|MRPS6]]|0.655|
|[[:human genes:g:gfm1|GFM1]]|0.654|
|[[:human genes:m:mrpl21|MRPL21]]|0.654|
|[[:human genes:n:nars2|NARS2]]|0.642|
|[[:human genes:y:yars2|YARS2]]|0.641|
|[[:human genes:p:pars2|PARS2]]|0.634|
|[[:human genes:m:mrps34|MRPS34]]|0.631|
|[[:human genes:m:mrpl23|MRPL23]]|0.63|
|[[:human genes:q:qrsl1|QRSL1]]|0.625|
|[[:human genes:m:mrps16|MRPS16]]|0.615|
|[[:human genes:t:tars2|TARS2]]|0.613|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.612|
|[[:human genes:d:dars2|DARS2]]|0.605|
|[[:human genes:m:mrp63|MRP63]]|0.603|
|[[:human genes:n:ndufc2|NDUFC2]]|0.602|
|[[:human genes:m:mrpl45|MRPL45]]|0.602|
|[[:human genes:f:ftsj2|FTSJ2]]|0.593|
|[[:human genes:m:mrps14|MRPS14]]|0.591|
|[[:human genes:r:rbfa|RBFA]]|0.589|
|[[:human genes:m:mrps21|MRPS21]]|0.588|
|[[:human genes:m:mrpl53|MRPL53]]|0.588|
|[[:human genes:b:bcs1l|BCS1L]]|0.588|
|[[:human genes:r:rars2|RARS2]]|0.586|
|[[:human genes:m:mrps5|MRPS5]]|0.585|
|[[:human genes:m:mrps25|MRPS25]]|0.582|
|[[:human genes:s:slc25a26|SLC25A26]]|0.581|
|[[:human genes:n:ndufb11|NDUFB11]]|0.578|
|[[:human genes:r:rpusd3|RPUSD3]]|0.577|
|[[:human genes:e:ears2|EARS2]]|0.576|
|[[:human genes:l:lars2|LARS2]]|0.573|
|[[:human genes:m:mrpl20|MRPL20]]|0.573|
|[[:human genes:c:cox16|COX16]]|0.57|
|[[:human genes:g:gfm2|GFM2]]|0.566|
|[[:human genes:s:selrc1|SELRC1]]|0.566|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.566|
|[[:human genes:a:atp5a1|ATP5A1]]|0.565|
|[[:human genes:n:ndufa1|NDUFA1]]|0.565|
|[[:human genes:m:mrpl3|MRPL3]]|0.562|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.56|
|[[:human genes:m:mrpl47|MRPL47]]|0.56|
|[[:human genes:a:atp5c1|ATP5C1]]|0.556|
|[[:human genes:m:mtg1|MTG1]]|0.555|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.555|
|[[:human genes:h:hars2|HARS2]]|0.551|
|[[:human genes:n:ndufa3|NDUFA3]]|0.551|
|[[:human genes:m:mars2|MARS2]]|0.549|
|[[:human genes:v:vars2|VARS2]]|0.548|
|[[:human genes:p:pnpt1|PNPT1]]|0.546|
|[[:human genes:g:gatc|GATC]]|0.545|
|[[:human genes:m:mrps12|MRPS12]]|0.545|
|[[:human genes:n:ndufb9|NDUFB9]]|0.544|
|[[:human genes:m:mrps9|MRPS9]]|0.542|
|[[:human genes:m:mrps10|MRPS10]]|0.542|
|[[:human genes:m:mterfd1|MTERFD1]]|0.542|
|[[:human genes:r:rpusd4|RPUSD4]]|0.541|
|[[:human genes:a:aars2|AARS2]]|0.541|
|[[:human genes:p:pet112|PET112]]|0.541|
|[[:human genes:f:fastkd5|FASTKD5]]|0.539|
|[[:human genes:s:sco2|SCO2]]|0.537|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.537|
|[[:human genes:m:mrps18a|MRPS18A]]|0.532|
|[[:human genes:m:mrpl15|MRPL15]]|0.531|
|[[:human genes:a:atp5d|ATP5D]]|0.529|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.527|
|[[:human genes:m:mtg2|MTG2]]|0.525|
|[[:human genes:c:c12orf65|C12orf65]]|0.524|
|[[:human genes:t:tefm|TEFM]]|0.523|
|[[:human genes:m:mrps23|MRPS23]]|0.522|
|[[:human genes:m:mrps26|MRPS26]]|0.522|
|[[:human genes:c:cox7b|COX7B]]|0.516|
|[[:human genes:m:mrpl44|MRPL44]]|0.516|
|[[:human genes:c:coa6|COA6]]|0.515|
|[[:human genes:m:mrpl12|MRPL12]]|0.514|
|[[:human genes:m:mrpl42|MRPL42]]|0.514|
|[[:human genes:c:coa3|COA3]]|0.513|
|[[:human genes:n:ndufb6|NDUFB6]]|0.512|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.511|
|[[:human genes:m:mtpap|MTPAP]]|0.511|
|[[:human genes:c:cox17|COX17]]|0.511|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.51|
|[[:human genes:p:polg2|POLG2]]|0.51|
|[[:human genes:s:sars2|SARS2]]|0.51|
|[[:human genes:f:fars2|FARS2]]|0.51|
|[[:human genes:m:mrps33|MRPS33]]|0.509|
|[[:human genes:n:ndufb5|NDUFB5]]|0.508|
|[[:human genes:m:mrpl4|MRPL4]]|0.506|
|[[:human genes:a:aifm1|AIFM1]]|0.504|
|[[:human genes:c:coq2|COQ2]]|0.501|
|[[:human genes:m:mrpl18|MRPL18]]|0.499|
|[[:human genes:a:atp5b|ATP5B]]|0.495|
|[[:human genes:t:tufm|TUFM]]|0.494|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.494|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.494|
|[[:human genes:m:mrps2|MRPS2]]|0.493|
|[[:human genes:n:ndufa2|NDUFA2]]|0.492|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.491|
|[[:human genes:n:ndufs2|NDUFS2]]|0.491|
|[[:human genes:a:atp5h|ATP5H]]|0.49|
|[[:human genes:p:pet117|PET117]]|0.484|
|[[:human genes:m:mrps27|MRPS27]]|0.479|
|[[:human genes:m:mrps22|MRPS22]]|0.479|
|[[:human genes:m:mrps11|MRPS11]]|0.478|
|[[:human genes:m:mettl17|METTL17]]|0.478|
|[[:human genes:c:c10orf2|C10orf2]]|0.478|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.476|
|[[:human genes:p:pdss1|PDSS1]]|0.476|
|[[:human genes:a:atp5sl|ATP5SL]]|0.475|
|[[:human genes:d:ddx28|DDX28]]|0.475|
|[[:human genes:w:wars2|WARS2]]|0.475|
|[[:human genes:c:c1qbp|C1QBP]]|0.473|
|[[:human genes:m:mrpl11|MRPL11]]|0.472|
|[[:human genes:m:mrps24|MRPS24]]|0.471|
|[[:human genes:c:chchd1|CHCHD1]]|0.466|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.464|
|[[:human genes:t:trub2|TRUB2]]|0.462|
|[[:human genes:m:mrps35|MRPS35]]|0.462|
|[[:human genes:n:ndufa11|NDUFA11]]|0.461|
|[[:human genes:m:mrpl55|MRPL55]]|0.461|
|[[:human genes:g:grsf1|GRSF1]]|0.46|
|[[:human genes:s:ssbp1|SSBP1]]|0.459|
|[[:human genes:m:mrpl13|MRPL13]]|0.459|
|[[:human genes:c:c17orf89|C17orf89]]|0.459|
|[[:human genes:c:clpp|CLPP]]|0.457|
|[[:human genes:e:ecsit|ECSIT]]|0.457|
|[[:human genes:n:ndufb3|NDUFB3]]|0.456|
|[[:human genes:c:cox6c|COX6C]]|0.456|
|[[:human genes:n:ndufs7|NDUFS7]]|0.456|
|[[:human genes:c:cox11|COX11]]|0.455|
|[[:human genes:p:ptcd3|PTCD3]]|0.454|
|[[:human genes:p:pitrm1|PITRM1]]|0.454|
|[[:human genes:n:ndufs5|NDUFS5]]|0.453|
|[[:human genes:c:cars2|CARS2]]|0.452|
|[[:human genes:h:higd2a|HIGD2A]]|0.452|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.451|
|[[:human genes:p:polg|POLG]]|0.451|
|[[:human genes:i:iba57|IBA57]]|0.451|
|[[:human genes:n:nfu1|NFU1]]|0.45|
|[[:human genes:a:atp5o|ATP5O]]|0.449|
|[[:human genes:c:coq5|COQ5]]|0.447|
|[[:human genes:m:mterfd2|MTERFD2]]|0.447|
|[[:human genes:d:dhx30|DHX30]]|0.447|
|[[:human genes:m:mrpl51|MRPL51]]|0.446|
|[[:human genes:a:acad9|ACAD9]]|0.444|
|[[:human genes:h:hccs|HCCS]]|0.444|
|[[:human genes:t:triap1|TRIAP1]]|0.443|
|[[:human genes:m:mrpl39|MRPL39]]|0.443|
|[[:human genes:c:coq3|COQ3]]|0.443|
|[[:human genes:e:elac2|ELAC2]]|0.443|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.442|
|[[:human genes:o:opa1|OPA1]]|0.442|
|[[:human genes:f:fastkd1|FASTKD1]]|0.442|
|[[:human genes:m:mrpl49|MRPL49]]|0.44|
|[[:human genes:m:mrps7|MRPS7]]|0.44|
|[[:human genes:d:dnlz|DNLZ]]|0.44|
|[[:human genes:p:pmm2|PMM2]]|0.44|
|[[:human genes:p:ppa2|PPA2]]|0.44|
|[[:human genes:m:mrpl36|MRPL36]]|0.437|
|[[:human genes:t:tmem242|TMEM242]]|0.436|
|[[:human genes:g:glrx5|GLRX5]]|0.436|
|[[:human genes:t:tfam|TFAM]]|0.436|
|[[:human genes:m:mipep|MIPEP]]|0.435|
|[[:human genes:a:alg6|ALG6]]|0.435|
|[[:human genes:m:malsu1|MALSU1]]|0.435|
|[[:human genes:d:dhrsx|DHRSX]]|0.434|
|[[:human genes:s:slc25a3|SLC25A3]]|0.433|
|[[:human genes:m:mrpl22|MRPL22]]|0.432|
|[[:human genes:n:nubpl|NUBPL]]|0.432|
|[[:human genes:p:pgm3|PGM3]]|0.432|
|[[:human genes:c:cox15|COX15]]|0.43|
|[[:human genes:n:ndufs8|NDUFS8]]|0.43|
|[[:human genes:c:crls1|CRLS1]]|0.429|
|[[:human genes:t:tomm22|TOMM22]]|0.429|
|[[:human genes:t:tfb1m|TFB1M]]|0.427|
|[[:human genes:t:tomm20|TOMM20]]|0.427|
|[[:human genes:a:atxn10|ATXN10]]|0.427|
|[[:human genes:c:coa5|COA5]]|0.425|
|[[:human genes:m:mrpl43|MRPL43]]|0.425|
|[[:human genes:l:lrpprc|LRPPRC]]|0.423|
|[[:human genes:n:ndufv1|NDUFV1]]|0.422|
|[[:human genes:m:mto1|MTO1]]|0.421|
|[[:human genes:t:taz|TAZ]]|0.418|
|[[:human genes:p:polrmt|POLRMT]]|0.418|
|[[:human genes:n:ndufs1|NDUFS1]]|0.418|
|[[:human genes:e:eral1|ERAL1]]|0.417|
|[[:human genes:a:atp5j|ATP5J]]|0.416|
|[[:human genes:n:ndufb4|NDUFB4]]|0.415|
|[[:human genes:s:slc25a52|SLC25A52]]|0.415|
|[[:human genes:n:ndufa6|NDUFA6]]|0.415|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.415|
|[[:human genes:m:mtif2|MTIF2]]|0.414|
|[[:human genes:f:fastkd2|FASTKD2]]|0.413|
|[[:human genes:a:atp5l|ATP5L]]|0.412|
|[[:human genes:a:alas1|ALAS1]]|0.412|
|[[:human genes:m:mrpl41|MRPL41]]|0.41|
|[[:human genes:t:tfb2m|TFB2M]]|0.409|
|[[:human genes:c:cox20|COX20]]|0.409|
|[[:human genes:m:mrpl17|MRPL17]]|0.409|
|[[:human genes:c:coq7|COQ7]]|0.407|
|[[:human genes:n:ndufa8|NDUFA8]]|0.407|
|[[:human genes:m:mrpl34|MRPL34]]|0.407|
|[[:human genes:t:trmt10c|TRMT10C]]|0.407|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.407|
|[[:human genes:a:angel2|ANGEL2]]|0.406|
|[[:human genes:m:mrpl27|MRPL27]]|0.405|
|[[:human genes:n:ndufa13|NDUFA13]]|0.405|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.405|
|[[:human genes:n:ndufb7|NDUFB7]]|0.403|
|[[:human genes:c:cox5a|COX5A]]|0.403|
|[[:human genes:a:atp5f1|ATP5F1]]|0.402|
|[[:human genes:m:mrps17|MRPS17]]|0.402|
|[[:human genes:m:mrpl46|MRPL46]]|0.401|
|[[:human genes:m:mbtps2|MBTPS2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 56/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|4/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|2/20|
|lung|8/75|
|lymphocyte|2/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 108
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WBSCR16 Expression in NALM6 Cells: 3.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>