======= WDR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR1
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9948|9948]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75083|O75083]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604734|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565). {ECO:0000250|UniProtKB:O88342, ECO:0000250|UniProtKB:Q9W7F2, ECO:0000269|PubMed:15629458, ECO:0000269|PubMed:18494608, ECO:0000269|PubMed:25792565}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|morphogenesis of follicular epithelium|
|establishment of planar polarity of follicular epithelium|
|establishment or maintenance of polarity of follicular epithelium|
|actomyosin, actin portion|
|actin filament fragmentation|
|maintenance of epithelial cell apical/basal polarity|
|maintenance of apical/basal cell polarity|
|actin filament depolymerization|
|positive regulation of actin filament depolymerization|
|maintenance of cell polarity|
|platelet formation|
|platelet morphogenesis|
|positive regulation of protein depolymerization|
|regulation of ventricular cardiac muscle cell membrane repolarization|
|establishment of tissue polarity|
|establishment of planar polarity|
|regulation of cardiac muscle cell membrane repolarization|
|podosome|
|regulation of membrane repolarization|
|protein depolymerization|
|positive regulation of protein complex disassembly|
|regulation of oligodendrocyte differentiation|
|morphogenesis of a polarized epithelium|
|apical junction assembly|
|sarcomere organization|
|establishment or maintenance of epithelial cell apical/basal polarity|
|cortical cytoskeleton organization|
|establishment or maintenance of bipolar cell polarity|
|establishment or maintenance of apical/basal cell polarity|
|actin polymerization or depolymerization|
|regulation of actin filament depolymerization|
|cortical actin cytoskeleton|
|myofibril assembly|
|regulation of glial cell differentiation|
|regulation of protein depolymerization|
|neutrophil migration|
|cell projection|
|granulocyte migration|
|cellular component assembly involved in morphogenesis|
|cell-cell junction assembly|
|regulation of protein complex disassembly|
|actomyosin structure organization|
|regulation of gliogenesis|
|myeloid leukocyte migration|
|platelet degranulation|
|striated muscle cell development|
|cell-cell junction organization|
|cellular protein complex disassembly|
|sensory perception of sound|
|muscle cell development|
|regulation of cell shape|
|sensory perception of mechanical stimulus|
|cell junction assembly|
|cell-cell junction|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|establishment or maintenance of cell polarity|
|positive regulation of supramolecular fiber organization|
|striated muscle cell differentiation|
|actin filament binding|
|cell junction organization|
|myeloid cell differentiation|
|positive regulation of cytoskeleton organization|
|actin filament organization|
|protein-containing complex disassembly|
|muscle cell differentiation|
|regulation of actin filament organization|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of cellular component size|
|leukocyte migration|
|regulation of actin filament-based process|
|cellular component disassembly|
|regulation of membrane potential|
|morphogenesis of an epithelium|
|supramolecular fiber organization|
|muscle structure development|
|regulation of ion transmembrane transport|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|neutrophil mediated immunity|
|regulation of anatomical structure size|
|myeloid leukocyte mediated immunity|
|regulation of cytoskeleton organization|
|cell junction|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|regulation of transmembrane transport|
|tissue morphogenesis|
|actin filament-based process|
|hematopoietic or lymphoid organ development|
|positive regulation of organelle organization|
|immune system development|
|regulation of ion transport|
|regulated exocytosis|
|cell morphogenesis|
|organelle assembly|
|leukocyte mediated immunity|
|exocytosis|
|regulation of neurogenesis|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|cell migration|
|sensory perception|
|secretion by cell|
|export from cell|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|immune effector process|
|cytoskeleton organization|
|epithelium development|
|secretion|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|locomotion|
|nervous system process|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|tissue development|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|regulation of transport|
|extracellular region|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.47|
|[[:human genes:t:thg1l|THG1L]]|0.466|
|[[:human genes:a:alg1|ALG1]]|0.464|
|[[:human genes:m:med16|MED16]]|0.46|
|[[:human genes:g:gemin8|GEMIN8]]|0.453|
|[[:human genes:g:gfpt1|GFPT1]]|0.451|
|[[:human genes:c:c14orf80|C14orf80]]|0.451|
|[[:human genes:t:tsen54|TSEN54]]|0.447|
|[[:human genes:t:tubd1|TUBD1]]|0.444|
|[[:human genes:p:pmm2|PMM2]]|0.437|
|[[:human genes:u:uap1|UAP1]]|0.432|
|[[:human genes:t:triap1|TRIAP1]]|0.431|
|[[:human genes:t:tbcb|TBCB]]|0.429|
|[[:human genes:r:rptor|RPTOR]]|0.425|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.42|
|[[:human genes:u:uhrf1|UHRF1]]|0.419|
|[[:human genes:c:c16orf59|C16orf59]]|0.416|
|[[:human genes:e:exoc4|EXOC4]]|0.416|
|[[:human genes:d:dr1|DR1]]|0.415|
|[[:human genes:n:nsmce1|NSMCE1]]|0.414|
|[[:human genes:b:bub3|BUB3]]|0.413|
|[[:human genes:g:gnb1l|GNB1L]]|0.413|
|[[:human genes:r:rnmt|RNMT]]|0.413|
|[[:human genes:t:ten1|TEN1]]|0.413|
|[[:human genes:s:spr|SPR]]|0.409|
|[[:human genes:p:pfn1|PFN1]]|0.409|
|[[:human genes:m:mtor|MTOR]]|0.405|
|[[:human genes:d:ddx55|DDX55]]|0.404|
|[[:human genes:r:rtcb|RTCB]]|0.403|
|[[:human genes:g:gmppb|GMPPB]]|0.402|
|[[:human genes:s:slc25a19|SLC25A19]]|0.402|
|[[:human genes:s:srp14|SRP14]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 356/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|20/28|
|bone|12/26|
|breast|13/33|
|central nervous system|32/56|
|cervix|3/4|
|colorectal|7/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|11/21|
|liver|7/20|
|lung|37/75|
|lymphocyte|9/16|
|ovary|13/26|
|pancreas|8/24|
|peripheral nervous system|10/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|12/22|
|urinary tract|12/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 753
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR1 Expression in NALM6 Cells: 8.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>