======= WDR43 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR43
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 43
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23160|23160]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15061|Q15061]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR43&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR43|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616195|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre- ribosomal RNA transcription by RNA polymerase I. {ECO:0000269|PubMed:17699751}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|Utp12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of rRNA processing|
|positive regulation of ribosome biogenesis|
|regulation of rRNA processing|
|regulation of ribosome biogenesis|
|positive regulation of transcription by RNA polymerase I|
|regulation of transcription by RNA polymerase I|
|fibrillar center|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|positive regulation of cellular component biogenesis|
|nucleolus|
|RNA processing|
|regulation of cellular component biogenesis|
|RNA binding|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.21|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.03|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.85|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.72|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.74|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.77|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.77|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.89|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.9|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.93|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.09|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.11|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|2.15|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.26|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.27|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.31|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:smg7|SMG7]]|0.509|
|[[:human genes:r:rpl14|RPL14]]|0.497|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.496|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.493|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.488|
|[[:human genes:p:pola2|POLA2]]|0.484|
|[[:human genes:c:cdc45|CDC45]]|0.482|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.481|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.479|
|[[:human genes:p:psmc6|PSMC6]]|0.477|
|[[:human genes:p:psmd11|PSMD11]]|0.476|
|[[:human genes:a:atp13a1|ATP13A1]]|0.475|
|[[:human genes:z:zfand5|ZFAND5]]|0.474|
|[[:human genes:r:rpl35|RPL35]]|0.469|
|[[:human genes:s:supt6h|SUPT6H]]|0.469|
|[[:human genes:p:pcf11|PCF11]]|0.467|
|[[:human genes:n:nol10|NOL10]]|0.465|
|[[:human genes:d:dtl|DTL]]|0.462|
|[[:human genes:r:rpl34|RPL34]]|0.461|
|[[:human genes:t:tceb3c|TCEB3C]]|0.461|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.456|
|[[:human genes:d:ddtl|DDTL]]|0.456|
|[[:human genes:c:cbwd3|CBWD3]]|0.456|
|[[:human genes:z:znf106|ZNF106]]|0.455|
|[[:human genes:c:cope|COPE]]|0.451|
|[[:human genes:c:copb1|COPB1]]|0.451|
|[[:human genes:c:cdca3|CDCA3]]|0.448|
|[[:human genes:p:psmb1|PSMB1]]|0.448|
|[[:human genes:r:rrp15|RRP15]]|0.447|
|[[:human genes:c:cbwd5|CBWD5]]|0.447|
|[[:human genes:r:rad51|RAD51]]|0.446|
|[[:human genes:r:rps12|RPS12]]|0.444|
|[[:human genes:m:med29|MED29]]|0.443|
|[[:human genes:p:psmd1|PSMD1]]|0.442|
|[[:human genes:p:pole|POLE]]|0.441|
|[[:human genes:p:psma6|PSMA6]]|0.44|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.44|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.439|
|[[:human genes:p:pan2|PAN2]]|0.438|
|[[:human genes:p:psmc1|PSMC1]]|0.435|
|[[:human genes:s:sel1l|SEL1L]]|0.433|
|[[:human genes:r:rrp7a|RRP7A]]|0.432|
|[[:human genes:t:ticrr|TICRR]]|0.432|
|[[:human genes:r:rps28|RPS28]]|0.432|
|[[:human genes:r:rps3|RPS3]]|0.432|
|[[:human genes:s:snrpa1|SNRPA1]]|0.432|
|[[:human genes:n:nup43|NUP43]]|0.43|
|[[:human genes:m:mbtd1|MBTD1]]|0.429|
|[[:human genes:v:vasn|VASN]]|0.429|
|[[:human genes:r:rrn3|RRN3]]|0.429|
|[[:human genes:t:terf2|TERF2]]|0.429|
|[[:human genes:p:psmc2|PSMC2]]|0.428|
|[[:human genes:p:psmb2|PSMB2]]|0.428|
|[[:human genes:c:copb2|COPB2]]|0.426|
|[[:human genes:c:cbwd6|CBWD6]]|0.426|
|[[:human genes:n:nol12|NOL12]]|0.426|
|[[:human genes:t:twistnb|TWISTNB]]|0.426|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.425|
|[[:human genes:c:ccdc94|CCDC94]]|0.424|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.424|
|[[:human genes:i:ik|IK]]|0.423|
|[[:human genes:o:orc6|ORC6]]|0.422|
|[[:human genes:a:adrm1|ADRM1]]|0.419|
|[[:human genes:p:pan3|PAN3]]|0.419|
|[[:human genes:o:ogfr|OGFR]]|0.418|
|[[:human genes:p:psmd7|PSMD7]]|0.417|
|[[:human genes:n:npipb5|NPIPB5]]|0.416|
|[[:human genes:o:orc1|ORC1]]|0.415|
|[[:human genes:s:ssh2|SSH2]]|0.415|
|[[:human genes:c:chchd3|CHCHD3]]|0.415|
|[[:human genes:r:rps3a|RPS3A]]|0.415|
|[[:human genes:u:upf1|UPF1]]|0.414|
|[[:human genes:h:hivep3|HIVEP3]]|0.413|
|[[:human genes:k:kpnb1|KPNB1]]|0.413|
|[[:human genes:s:smg5|SMG5]]|0.413|
|[[:human genes:n:nbpf10|NBPF10]]|0.413|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.41|
|[[:human genes:r:rpl38|RPL38]]|0.408|
|[[:human genes:p:polr2a|POLR2A]]|0.407|
|[[:human genes:p:psmd13|PSMD13]]|0.407|
|[[:human genes:p:psmb4|PSMB4]]|0.406|
|[[:human genes:n:nip7|NIP7]]|0.406|
|[[:human genes:p:psmd3|PSMD3]]|0.406|
|[[:human genes:n:nop16|NOP16]]|0.406|
|[[:human genes:s:sart1|SART1]]|0.405|
|[[:human genes:p:psmd6|PSMD6]]|0.405|
|[[:human genes:p:psmc4|PSMC4]]|0.404|
|[[:human genes:c:chd4|CHD4]]|0.404|
|[[:human genes:r:rad21|RAD21]]|0.404|
|[[:human genes:i:igfn1|IGFN1]]|0.404|
|[[:human genes:t:top1mt|TOP1MT]]|0.404|
|[[:human genes:l:lad1|LAD1]]|0.403|
|[[:human genes:n:nup153|NUP153]]|0.403|
|[[:human genes:r:rnpc3|RNPC3]]|0.403|
|[[:human genes:m:mdm2|MDM2]]|0.403|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.402|
|[[:human genes:c:ctage4|CTAGE4]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 738/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 28
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR43 Expression in NALM6 Cells: 7.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>