======= WDR83 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR83
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 83
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84292|84292]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BRX9|Q9BRX9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR83&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR83|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616850|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|catalytic step 2 spliceosome|
|spliceosomal complex|
|endosome membrane|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|protein phosphorylation|
|phosphorylation|
|RNA metabolic process|
|intracellular signal transduction|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-2.47|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.03|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.83|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.82|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.81|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.99|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.01|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.01|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.01|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.04|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.08|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.16|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.24|
|[[:results:exp461|BS-181 20μM R08 exp461]]|2.33|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.42|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.92|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|3.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dhx35|DHX35]]|0.61|
|[[:human genes:p:pmvk|PMVK]]|0.511|
|[[:human genes:p:ptar1|PTAR1]]|0.475|
|[[:human genes:c:cxorf56|CXorf56]]|0.434|
|[[:human genes:d:dph1|DPH1]]|0.415|
|[[:human genes:c:ccdc130|CCDC130]]|0.413|
|[[:human genes:k:kti12|KTI12]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 22/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|2/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|2/16|
|ovary|1/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1200
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR83 Expression in NALM6 Cells: 4.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>