======= WDR92 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR92
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 92
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=116143|116143]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96MX6|Q96MX6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR92&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR92|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to act as a modulator of apoptosis. {ECO:0000269|PubMed:16487927}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin binding|
|apoptotic process|
|programmed cell death|
|cell death|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.97|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.88|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.87|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.75|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.73|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.86|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.08|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.518|
|[[:human genes:g:gemin8|GEMIN8]]|0.496|
|[[:human genes:d:dpagt1|DPAGT1]]|0.479|
|[[:human genes:g:gemin6|GEMIN6]]|0.477|
|[[:human genes:r:rpp21|RPP21]]|0.476|
|[[:human genes:g:gpn2|GPN2]]|0.474|
|[[:human genes:v:vezt|VEZT]]|0.474|
|[[:human genes:a:atxn10|ATXN10]]|0.466|
|[[:human genes:a:atic|ATIC]]|0.461|
|[[:human genes:s:snapc5|SNAPC5]]|0.459|
|[[:human genes:g:gemin7|GEMIN7]]|0.457|
|[[:human genes:g:gmppb|GMPPB]]|0.454|
|[[:human genes:d:dolk|DOLK]]|0.444|
|[[:human genes:r:rnmt|RNMT]]|0.437|
|[[:human genes:r:rpia|RPIA]]|0.437|
|[[:human genes:a:adsl|ADSL]]|0.435|
|[[:human genes:d:ddx20|DDX20]]|0.433|
|[[:human genes:r:rft1|RFT1]]|0.429|
|[[:human genes:r:rabggtb|RABGGTB]]|0.426|
|[[:human genes:d:dctn6|DCTN6]]|0.425|
|[[:human genes:m:med16|MED16]]|0.425|
|[[:human genes:f:fh|FH]]|0.425|
|[[:human genes:t:tsen54|TSEN54]]|0.42|
|[[:human genes:r:rtcb|RTCB]]|0.42|
|[[:human genes:d:dr1|DR1]]|0.42|
|[[:human genes:a:alg1|ALG1]]|0.416|
|[[:human genes:e:ercc2|ERCC2]]|0.415|
|[[:human genes:t:triap1|TRIAP1]]|0.414|
|[[:human genes:e:eno1|ENO1]]|0.413|
|[[:human genes:s:srp14|SRP14]]|0.412|
|[[:human genes:v:vma21|VMA21]]|0.411|
|[[:human genes:u:uxt|UXT]]|0.41|
|[[:human genes:l:lsm10|LSM10]]|0.409|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.409|
|[[:human genes:c:cep57|CEP57]]|0.408|
|[[:human genes:c:cmtr1|CMTR1]]|0.407|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.407|
|[[:human genes:g:gfpt1|GFPT1]]|0.406|
|[[:human genes:d:ddx1|DDX1]]|0.406|
|[[:human genes:g:gnb1l|GNB1L]]|0.405|
|[[:human genes:e:exoc4|EXOC4]]|0.404|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.402|
|[[:human genes:e:elp2|ELP2]]|0.4|
|[[:human genes:n:n6amt1|N6AMT1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 343/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|12/28|
|blood|10/28|
|bone|12/25|
|breast|16/33|
|central nervous system|28/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|7/15|
|kidney|5/21|
|liver|7/20|
|lung|37/75|
|lymphocyte|4/14|
|ovary|11/26|
|pancreas|17/24|
|peripheral nervous system|10/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|4/7|
|thyroid|1/2|
|upper aerodigestive|19/22|
|urinary tract|17/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1134
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR92 Expression in NALM6 Cells: 4.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>