======= WFIKKN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WFIKKN2
  * **<color #00a2e8>Official Name</color>**: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=124857|124857]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TEU8|Q8TEU8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WFIKKN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WFIKKN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610895|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|Kazal 2|
|Kunitz BPTI|
|NTR|
|WAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|metalloendopeptidase inhibitor activity|
|transforming growth factor beta binding|
|receptor antagonist activity|
|negative regulation of DNA binding|
|negative regulation of signaling receptor activity|
|muscle fiber development|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|roof of mouth development|
|serine-type endopeptidase inhibitor activity|
|transforming growth factor beta receptor signaling pathway|
|negative regulation of protein binding|
|regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|regulation of DNA binding|
|striated muscle cell development|
|negative regulation of cellular response to growth factor stimulus|
|muscle cell development|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|negative regulation of binding|
|regulation of signaling receptor activity|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|striated muscle cell differentiation|
|regulation of protein binding|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of endopeptidase activity|
|muscle cell differentiation|
|negative regulation of peptidase activity|
|regulation of cellular response to growth factor stimulus|
|negative regulation of proteolysis|
|regulation of binding|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|muscle structure development|
|skeletal system development|
|cellular response to growth factor stimulus|
|response to growth factor|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|extracellular space|
|negative regulation of response to stimulus|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7844
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WFIKKN2 Expression in NALM6 Cells: -3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>