======= WNT3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WNT3
  * **<color #00a2e8>Official Name</color>**: Wnt family member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7473|7473]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56703|P56703]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WNT3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WNT3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/165330|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406). {ECO:0000250|UniProtKB:P17553, ECO:0000269|PubMed:14872406, ECO:0000269|PubMed:26902720, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|wnt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Spemann organizer formation at the anterior end of the primitive streak|
|canonical Wnt signaling pathway involved in stem cell proliferation|
|positive regulation of collateral sprouting in absence of injury|
|canonical Wnt signaling pathway involved in osteoblast differentiation|
|canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation|
|mesenchymal stem cell differentiation|
|regulation of collateral sprouting in absence of injury|
|canonical Wnt signaling pathway involved in regulation of cell proliferation|
|Spemann organizer formation|
|canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|
|Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|
|positive regulation of collateral sprouting|
|limb bud formation|
|dorsal/ventral axis specification|
|Wnt signalosome|
|midbrain dopaminergic neuron differentiation|
|regulation of collateral sprouting|
|negative regulation of axon extension involved in axon guidance|
|developmental induction|
|embryonic hindlimb morphogenesis|
|negative regulation of axon guidance|
|dopaminergic neuron differentiation|
|regulation of axon extension involved in axon guidance|
|embryonic forelimb morphogenesis|
|receptor ligand activity|
|hindlimb morphogenesis|
|head morphogenesis|
|frizzled binding|
|forelimb morphogenesis|
|negative regulation of axon extension|
|regulation of axon guidance|
|body morphogenesis|
|anterior/posterior axis specification|
|stem cell proliferation|
|negative regulation of chemotaxis|
|mammary gland epithelium development|
|mesoderm formation|
|endocytic vesicle membrane|
|cellular response to retinoic acid|
|negative regulation of axonogenesis|
|mesoderm morphogenesis|
|dorsal/ventral pattern formation|
|positive regulation of axonogenesis|
|midbrain development|
|axis specification|
|canonical Wnt signaling pathway|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|Golgi lumen|
|negative regulation of developmental growth|
|response to retinoic acid|
|regulation of extent of cell growth|
|formation of primary germ layer|
|mesoderm development|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|osteoblast differentiation|
|mammary gland development|
|appendage morphogenesis|
|limb morphogenesis|
|negative regulation of neuron projection development|
|positive regulation of cell morphogenesis involved in differentiation|
|stem cell differentiation|
|gastrulation|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|positive regulation of Wnt signaling pathway|
|central nervous system neuron differentiation|
|appendage development|
|limb development|
|regulation of cell size|
|negative regulation of cell projection organization|
|negative regulation of cell growth|
|regulation of axonogenesis|
|cellular response to acid chemical|
|regulation of chemotaxis|
|anterior/posterior pattern specification|
|negative regulation of neuron differentiation|
|extracellular matrix|
|negative regulation of growth|
|protein domain specific binding|
|cell fate commitment|
|positive regulation of growth|
|axon guidance|
|ossification|
|neuron projection guidance|
|positive regulation of neuron projection development|
|negative regulation of neurogenesis|
|endoplasmic reticulum lumen|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|regulation of developmental growth|
|regionalization|
|negative regulation of cell development|
|response to acid chemical|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|negative regulation of response to external stimulus|
|positive regulation of neuron differentiation|
|axonogenesis|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|axon development|
|gland development|
|regulation of cell growth|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|cell morphogenesis involved in neuron differentiation|
|pattern specification process|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|cell part morphogenesis|
|cellular response to lipid|
|positive regulation of nervous system development|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|gamete generation|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|multi-organism reproductive process|
|regulation of cellular component movement|
|neuron differentiation|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|locomotion|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|extracellular region|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.7|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.74|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.75|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3844
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WNT3 Expression in NALM6 Cells: 1.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>