======= WNT6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WNT6
  * **<color #00a2e8>Official Name</color>**: Wnt family member 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7475|7475]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6F9|Q9Y6F9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WNT6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WNT6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604663|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway. {ECO:0000269|PubMed:22370641}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|wnt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of tooth mineralization|
|epithelial-mesenchymal cell signaling|
|cornea development in camera-type eye|
|regulation of tooth mineralization|
|positive regulation of odontogenesis|
|nephron tubule formation|
|regulation of odontogenesis|
|frizzled binding|
|branching involved in ureteric bud morphogenesis|
|positive regulation of biomineralization|
|positive regulation of biomineral tissue development|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|endocytic vesicle membrane|
|renal tubule morphogenesis|
|cellular response to retinoic acid|
|nephron tubule development|
|renal tubule development|
|positive regulation of animal organ morphogenesis|
|odontogenesis of dentin-containing tooth|
|kidney morphogenesis|
|ureteric bud development|
|axis specification|
|mesonephric tubule development|
|mesonephric epithelium development|
|mesonephros development|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|nephron epithelium development|
|Golgi lumen|
|response to retinoic acid|
|odontogenesis|
|embryonic epithelial tube formation|
|nephron development|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|tube formation|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|cellular response to acid chemical|
|extracellular matrix|
|cell fate commitment|
|regulation of animal organ morphogenesis|
|kidney development|
|renal system development|
|endoplasmic reticulum lumen|
|epithelial tube morphogenesis|
|camera-type eye development|
|urogenital system development|
|response to acid chemical|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|eye development|
|visual system development|
|sensory system development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|pattern specification process|
|cellular response to lipid|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|cell surface|
|tube morphogenesis|
|tube development|
|response to lipid|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|embryo development|
|neuron differentiation|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|cell-cell signaling|
|positive regulation of developmental process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|extracellular space|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.93|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.86|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4457
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WNT6 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>