======= WNT9A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WNT9A
  * **<color #00a2e8>Official Name</color>**: Wnt family member 9A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7483|7483]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14904|O14904]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WNT9A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WNT9A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602863|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta- catenin signaling pathway. Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Plays a redundant role in maintaining joint integrity. {ECO:0000250|UniProtKB:O42280, ECO:0000250|UniProtKB:Q8R5M2}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|wnt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cornea development in camera-type eye|
|iris morphogenesis|
|embryonic skeletal joint development|
|negative regulation of chondrocyte differentiation|
|negative regulation of cartilage development|
|positive regulation of smoothened signaling pathway|
|receptor ligand activity|
|embryonic forelimb morphogenesis|
|frizzled binding|
|forelimb morphogenesis|
|regulation of chondrocyte differentiation|
|cellular response to retinoic acid|
|regulation of cartilage development|
|regulation of smoothened signaling pathway|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|canonical Wnt signaling pathway|
|negative regulation of cysteine-type endopeptidase activity|
|embryonic skeletal system morphogenesis|
|response to retinoic acid|
|camera-type eye morphogenesis|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|embryonic skeletal system development|
|eye morphogenesis|
|limb morphogenesis|
|appendage morphogenesis|
|mitotic cell cycle checkpoint|
|appendage development|
|limb development|
|cell cycle checkpoint|
|cellular response to acid chemical|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|skeletal system morphogenesis|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|cell fate commitment|
|negative regulation of peptidase activity|
|sensory organ morphogenesis|
|embryonic organ morphogenesis|
|negative regulation of mitotic cell cycle|
|camera-type eye development|
|response to acid chemical|
|negative regulation of proteolysis|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|eye development|
|visual system development|
|sensory system development|
|regulation of endopeptidase activity|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|embryonic organ development|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|skeletal system development|
|cellular response to lipid|
|sensory organ development|
|embryonic morphogenesis|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|negative regulation of cell population proliferation|
|mitotic cell cycle|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|response to lipid|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|negative regulation of cell death|
|cell cycle process|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|regulation of hydrolase activity|
|cell cycle|
|positive regulation of developmental process|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of cell death|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12845
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WNT9A Expression in NALM6 Cells: -1.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>