======= WNT9B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WNT9B
  * **<color #00a2e8>Official Name</color>**: Wnt family member 9B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7484|7484]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14905|O14905]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WNT9B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WNT9B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602864|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand for members of the frizzled family of seven transmembrane receptors (PubMed:20093360). Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity). {ECO:0000250|UniProtKB:O35468, ECO:0000305|PubMed:20093360}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|wnt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment of planar polarity involved in nephron morphogenesis|
|non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|
|mesenchymal stem cell maintenance involved in nephron morphogenesis|
|mesonephric duct formation|
|kidney rudiment formation|
|regulation of asymmetric cell division|
|mesonephric duct morphogenesis|
|nephric duct formation|
|uterus morphogenesis|
|metanephric tubule formation|
|negative regulation of stem cell population maintenance|
|mesonephric tubule formation|
|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|
|cornea development in camera-type eye|
|mesonephric duct development|
|Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|
|metanephric tubule morphogenesis|
|nephric duct morphogenesis|
|collecting duct development|
|midbrain dopaminergic neuron differentiation|
|co-receptor binding|
|nephric duct development|
|nephron tubule formation|
|metanephric tubule development|
|regulation of epithelial cell differentiation involved in kidney development|
|metanephric epithelium development|
|uterus development|
|establishment of planar polarity|
|male genitalia development|
|regulation of metanephros development|
|establishment of tissue polarity|
|regulation of stem cell population maintenance|
|dopaminergic neuron differentiation|
|receptor ligand activity|
|frizzled binding|
|morphogenesis of a polarized epithelium|
|branching involved in ureteric bud morphogenesis|
|embryonic cranial skeleton morphogenesis|
|genitalia development|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|regulation of kidney development|
|nephron tubule morphogenesis|
|somatic stem cell population maintenance|
|cranial skeletal system development|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|cellular response to retinoic acid|
|nephron tubule development|
|renal tubule development|
|metanephros development|
|kidney morphogenesis|
|ureteric bud development|
|midbrain development|
|mesonephric epithelium development|
|mesonephric tubule development|
|canonical Wnt signaling pathway|
|roof of mouth development|
|mesonephros development|
|embryonic skeletal system morphogenesis|
|nephron epithelium development|
|Wnt signaling pathway, planar cell polarity pathway|
|response to retinoic acid|
|regulation of establishment of planar polarity|
|embryonic epithelial tube formation|
|nephron development|
|embryonic skeletal system development|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|epithelial tube formation|
|non-canonical Wnt signaling pathway|
|stem cell population maintenance|
|maintenance of cell number|
|regulation of tube size|
|regulation of epithelial cell differentiation|
|morphogenesis of embryonic epithelium|
|tube formation|
|cellular response to starvation|
|male sex differentiation|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|regulation of cell division|
|central nervous system neuron differentiation|
|regulation of morphogenesis of an epithelium|
|response to starvation|
|cellular response to acid chemical|
|cellular response to nutrient levels|
|skeletal system morphogenesis|
|cell fate commitment|
|regulation of animal organ morphogenesis|
|cellular response to extracellular stimulus|
|sex differentiation|
|kidney development|
|renal system development|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|camera-type eye development|
|urogenital system development|
|cellular response to external stimulus|
|response to acid chemical|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|eye development|
|visual system development|
|sensory system development|
|in utero embryonic development|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|skeletal system development|
|response to nutrient levels|
|regulation of anatomical structure size|
|cellular response to lipid|
|response to extracellular stimulus|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|brain development|
|head development|
|tube development|
|response to lipid|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|neuron differentiation|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|neurogenesis|
|cellular response to stress|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.598|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6910
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WNT9B Expression in NALM6 Cells: 2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>