======= XPO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: XPO1
  * **<color #00a2e8>Official Name</color>**: exportin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7514|7514]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14980|O14980]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=XPO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20XPO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602559|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. {ECO:0000269|PubMed:14612415, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:20921223, ECO:0000269|PubMed:9311922, ECO:0000269|PubMed:9323133, ECO:0000269|PubMed:9837918}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IBN N|
|Xpo1|
|CRM1 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|annulate lamellae|
|ribosomal small subunit export from nucleus|
|ribosomal large subunit export from nucleus|
|nuclear export signal receptor activity|
|ribosomal subunit export from nucleus|
|ribosome localization|
|rRNA-containing ribonucleoprotein complex export from nucleus|
|Ran GTPase binding|
|regulation of protein export from nucleus|
|regulation of centrosome duplication|
|Cajal body|
|intracellular transport of virus|
|host cell|
|transport of virus|
|regulation of centrosome cycle|
|multi-organism transport|
|multi-organism localization|
|kinetochore|
|regulation of nucleocytoplasmic transport|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|protein export from nucleus|
|mRNA transport|
|ribonucleoprotein complex|
|nuclear export|
|protein localization to nucleus|
|regulation of mRNA stability|
|nuclear envelope|
|regulation of RNA stability|
|regulation of microtubule cytoskeleton organization|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of mRNA catabolic process|
|RNA localization|
|regulation of microtubule-based process|
|regulation of intracellular protein transport|
|nuclear membrane|
|nucleobase-containing compound transport|
|protein domain specific binding|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|ribosome biogenesis|
|regulation of mRNA metabolic process|
|regulation of intracellular transport|
|establishment of organelle localization|
|regulation of protein catabolic process|
|ribonucleoprotein complex biogenesis|
|posttranscriptional regulation of gene expression|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|organelle localization|
|protein-containing complex|
|intracellular membrane-bounded organelle|
|viral process|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|regulation of cellular localization|
|intracellular protein transport|
|regulation of catabolic process|
|response to drug|
|regulation of protein localization|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of gene expression|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-2.97|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-2.69|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.65|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.3|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-2.29|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-2.24|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-2.05|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-2.05|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.97|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.86|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.79|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.76|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.73|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.7|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.78|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.8|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.81|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.84|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.93|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.95|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.97|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|2.06|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.07|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|2.12|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.13|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|2.14|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|2.17|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.18|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nupl1|NUPL1]]|0.435|
|[[:human genes:p:psmd11|PSMD11]]|0.431|
|[[:human genes:r:ranbp3|RANBP3]]|0.429|
|[[:human genes:s:srrm2|SRRM2]]|0.423|
|[[:human genes:s:smg1|SMG1]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 398
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='XPO1 Expression in NALM6 Cells: 9.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>