======= XPO5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: XPO5
  * **<color #00a2e8>Official Name</color>**: exportin 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57510|57510]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HAV4|Q9HAV4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=XPO5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20XPO5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607845|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Xpo1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of RNA interference|
|RNA nuclear export complex|
|pre-miRNA export from nucleus|
|RISC complex binding|
|regulation of RNA interference|
|pre-miRNA binding|
|nuclear export signal receptor activity|
|RISC complex|
|miRNA metabolic process|
|positive regulation of posttranscriptional gene silencing|
|Ran GTPase binding|
|regulation of protein export from nucleus|
|gene silencing by miRNA|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|tRNA binding|
|gene silencing by RNA|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|regulation of nucleocytoplasmic transport|
|RNA export from nucleus|
|regulation of gene silencing|
|protein export from nucleus|
|gene silencing|
|nuclear export|
|mRNA binding|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|regulation of intracellular protein transport|
|regulation of gene expression, epigenetic|
|nucleobase-containing compound transport|
|nucleocytoplasmic transport|
|nuclear transport|
|regulation of intracellular transport|
|ncRNA metabolic process|
|posttranscriptional regulation of gene expression|
|regulation of cellular protein localization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cellular localization|
|intracellular protein transport|
|regulation of protein localization|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|negative regulation of gene expression|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.92|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.46|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-2.43|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.43|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.38|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.33|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.25|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-2.23|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-2.19|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-2.14|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.13|
|[[:results:exp302|35°C R06 exp302]]|-2.12|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-2.11|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-2.08|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-2.08|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-2.07|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.99|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.99|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.98|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|-1.97|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.95|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.82|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.8|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.77|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.74|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.71|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.13|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.556|
|[[:human genes:s:spcs3|SPCS3]]|0.432|
|[[:human genes:t:tsen34|TSEN34]]|0.426|
|[[:human genes:g:gnb1l|GNB1L]]|0.425|
|[[:human genes:a:alg13|ALG13]]|0.422|
|[[:human genes:g:gfpt1|GFPT1]]|0.404|
|[[:human genes:t:tti2|TTI2]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 306/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|9/28|
|bone|4/26|
|breast|13/33|
|central nervous system|23/56|
|cervix|2/4|
|colorectal|6/17|
|esophagus|6/13|
|fibroblast|1/1|
|gastric|6/16|
|kidney|7/21|
|liver|3/20|
|lung|31/75|
|lymphocyte|13/16|
|ovary|9/26|
|pancreas|12/24|
|peripheral nervous system|4/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|13/24|
|soft tissue|5/9|
|thyroid|2/2|
|upper aerodigestive|12/22|
|urinary tract|19/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2085
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='XPO5 Expression in NALM6 Cells: 7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>