======= XRCC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: XRCC2
  * **<color #00a2e8>Official Name</color>**: X-ray repair cross complementing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7516|7516]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43543|O43543]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=XRCC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20XRCC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600375|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. {ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:11834724, ECO:0000269|PubMed:21276791, ECO:0000269|PubMed:23149936, ECO:0000269|PubMed:27233470}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rad51|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|strand invasion|
|Rad51B-Rad51C-Rad51D-XRCC2 complex|
|four-way junction DNA binding|
|regulation of fibroblast apoptotic process|
|replication fork|
|response to X-ray|
|DNA-dependent ATPase activity|
|response to gamma radiation|
|somitogenesis|
|centrosome cycle|
|multicellular organism growth|
|somite development|
|microtubule organizing center organization|
|segmentation|
|double-strand break repair via homologous recombination|
|recombinational repair|
|negative regulation of neuron apoptotic process|
|response to ionizing radiation|
|double-strand break repair|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|anterior/posterior pattern specification|
|DNA recombination|
|meiotic cell cycle|
|regulation of neuron death|
|regionalization|
|in utero embryonic development|
|developmental growth|
|growth|
|pattern specification process|
|response to radiation|
|positive regulation of neurogenesis|
|microtubule cytoskeleton organization|
|centrosome|
|DNA repair|
|positive regulation of nervous system development|
|positive regulation of cell development|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|microtubule-based process|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|regulation of neurogenesis|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|embryo development|
|negative regulation of cell death|
|cell cycle process|
|cytoskeleton organization|
|epithelium development|
|response to abiotic stimulus|
|cell cycle|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|neurogenesis|
|regulation of cell death|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.39|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.11|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-2.04|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.94|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.93|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.77|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.74|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.505|
|[[:human genes:m:mcm9|MCM9]]|0.495|
|[[:human genes:p:ppcs|PPCS]]|0.46|
|[[:human genes:n:nbn|NBN]]|0.459|
|[[:human genes:x:xrcc3|XRCC3]]|0.457|
|[[:human genes:t:ten1|TEN1]]|0.456|
|[[:human genes:r:rad51b|RAD51B]]|0.436|
|[[:human genes:g:gemin8|GEMIN8]]|0.43|
|[[:human genes:r:rabggtb|RABGGTB]]|0.421|
|[[:human genes:a:alg1|ALG1]]|0.419|
|[[:human genes:m:mcm8|MCM8]]|0.418|
|[[:human genes:t:thg1l|THG1L]]|0.415|
|[[:human genes:g:gmppb|GMPPB]]|0.412|
|[[:human genes:a:adsl|ADSL]]|0.408|
|[[:human genes:u:uhrf1|UHRF1]]|0.404|
|[[:human genes:n:nae1|NAE1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 55/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|3/28|
|bone|3/26|
|breast|5/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|5/75|
|lymphocyte|1/16|
|ovary|3/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1982
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='XRCC2 Expression in NALM6 Cells: 7.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>