======= XRN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: XRN1
  * **<color #00a2e8>Official Name</color>**: 5'-3' exoribonuclease 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54464|54464]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IZH2|Q8IZH2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=XRN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20XRN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607994|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). {ECO:0000250|UniProtKB:P97789, ECO:0000269|PubMed:18172165}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|XRN N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to puromycin|
|response to puromycin|
|5-3 exoribonuclease activity|
|cellular response to cycloheximide|
|response to cycloheximide|
|G-quadruplex RNA binding|
|G-quadruplex DNA binding|
|response to fungicide|
|nuclear mRNA surveillance|
|nuclear RNA surveillance|
|histone mRNA catabolic process|
|RNA surveillance|
|rRNA catabolic process|
|negative regulation of telomere maintenance via telomerase|
|telomerase RNA binding|
|negative regulation of telomere maintenance via telomere lengthening|
|ncRNA catabolic process|
|histone mRNA metabolic process|
|negative regulation of telomere maintenance|
|response to testosterone|
|negative regulation of DNA biosynthetic process|
|RNA phosphodiester bond hydrolysis, exonucleolytic|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|regulation of telomere maintenance|
|cellular response to alcohol|
|P-body|
|cellular response to ketone|
|response to antineoplastic agent|
|regulation of DNA biosynthetic process|
|cellular response to antibiotic|
|negative regulation of DNA metabolic process|
|negative regulation of translation|
|negative regulation of chromosome organization|
|negative regulation of cellular amide metabolic process|
|response to purine-containing compound|
|RNA phosphodiester bond hydrolysis|
|regulation of mRNA stability|
|regulation of RNA stability|
|response to ketone|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|cellular response to toxic substance|
|mRNA catabolic process|
|rRNA metabolic process|
|response to alcohol|
|RNA catabolic process|
|synapse|
|nucleic acid phosphodiester bond hydrolysis|
|response to antibiotic|
|regulation of mRNA metabolic process|
|regulation of chromosome organization|
|regulation of translation|
|regulation of DNA metabolic process|
|neuronal cell body|
|negative regulation of organelle organization|
|nucleobase-containing compound catabolic process|
|cellular response to drug|
|regulation of cellular amide metabolic process|
|dendrite|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|response to toxic substance|
|posttranscriptional regulation of gene expression|
|cellular response to organic cyclic compound|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|mRNA metabolic process|
|negative regulation of cellular component organization|
|regulation of cellular catabolic process|
|response to lipid|
|cellular macromolecule catabolic process|
|response to hormone|
|response to organic cyclic compound|
|regulation of catabolic process|
|response to organonitrogen compound|
|response to drug|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.11|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.04|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.87|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.83|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.8|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.77|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.01|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:edc4|EDC4]]|0.405|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 107/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|6/28|
|bone|2/26|
|breast|5/33|
|central nervous system|7/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|3/21|
|liver|0/20|
|lung|15/75|
|lymphocyte|4/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|2/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1268
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='XRN1 Expression in NALM6 Cells: 6.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>