======= YARS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YARS1
  * **<color #00a2e8>Official Name</color>**: tyrosyl-tRNA synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8565|8565]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54577|P54577]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YARS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YARS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603623|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA bind|
|tRNA-synt 1b|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tyrosine-tRNA ligase activity|
|tyrosyl-tRNA aminoacylation|
|interleukin-8 receptor binding|
|aminoacyl-tRNA synthetase multienzyme complex|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA binding|
|tRNA metabolic process|
|nuclear body|
|cellular amino acid metabolic process|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|apoptotic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|programmed cell death|
|cell death|
|RNA binding|
|organonitrogen compound biosynthetic process|
|ATP binding|
|extracellular space|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-2.62|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-2.51|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.3|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.08|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.05|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-2|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.83|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.72|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.7|
|[[:results:exp539|42°C R08 exp539]]|1.71|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.71|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.72|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.76|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.84|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.86|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.86|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.9|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.92|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.93|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.02|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.07|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.13|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.16|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.2|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.31|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.53|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.613|
|[[:human genes:r:rtcb|RTCB]]|0.592|
|[[:human genes:g:gmppb|GMPPB]]|0.592|
|[[:human genes:m:mars|MARS]]|0.585|
|[[:human genes:r:rnmt|RNMT]]|0.565|
|[[:human genes:u:uhrf1|UHRF1]]|0.56|
|[[:human genes:c:cct7|CCT7]]|0.555|
|[[:human genes:n:nars|NARS]]|0.551|
|[[:human genes:d:ddx20|DDX20]]|0.545|
|[[:human genes:a:adsl|ADSL]]|0.541|
|[[:human genes:t:thg1l|THG1L]]|0.539|
|[[:human genes:p:pelo|PELO]]|0.528|
|[[:human genes:a:alg2|ALG2]]|0.522|
|[[:human genes:r:rpp21|RPP21]]|0.514|
|[[:human genes:d:dpagt1|DPAGT1]]|0.511|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.508|
|[[:human genes:d:dhps|DHPS]]|0.507|
|[[:human genes:v:vrk1|VRK1]]|0.506|
|[[:human genes:p:pmm2|PMM2]]|0.503|
|[[:human genes:a:alg1|ALG1]]|0.502|
|[[:human genes:g:gemin5|GEMIN5]]|0.502|
|[[:human genes:a:alg13|ALG13]]|0.499|
|[[:human genes:r:rptor|RPTOR]]|0.498|
|[[:human genes:h:hspd1|HSPD1]]|0.498|
|[[:human genes:a:aars|AARS]]|0.497|
|[[:human genes:z:zrsr2|ZRSR2]]|0.497|
|[[:human genes:a:atxn10|ATXN10]]|0.493|
|[[:human genes:g:gnb1l|GNB1L]]|0.493|
|[[:human genes:p:polr3h|POLR3H]]|0.491|
|[[:human genes:t:tgs1|TGS1]]|0.49|
|[[:human genes:t:telo2|TELO2]]|0.49|
|[[:human genes:e:exoc4|EXOC4]]|0.489|
|[[:human genes:t:triap1|TRIAP1]]|0.486|
|[[:human genes:g:gfpt1|GFPT1]]|0.482|
|[[:human genes:e:eif4e|EIF4E]]|0.48|
|[[:human genes:e:elac2|ELAC2]]|0.478|
|[[:human genes:m:med16|MED16]]|0.478|
|[[:human genes:u:uxt|UXT]]|0.477|
|[[:human genes:v:vezt|VEZT]]|0.476|
|[[:human genes:u:uap1|UAP1]]|0.475|
|[[:human genes:o:osgep|OSGEP]]|0.475|
|[[:human genes:d:dicer1|DICER1]]|0.472|
|[[:human genes:t:trmt5|TRMT5]]|0.472|
|[[:human genes:t:tprkb|TPRKB]]|0.472|
|[[:human genes:t:thoc3|THOC3]]|0.47|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.47|
|[[:human genes:c:ccdc101|CCDC101]]|0.47|
|[[:human genes:p:psmg4|PSMG4]]|0.469|
|[[:human genes:p:polr3b|POLR3B]]|0.466|
|[[:human genes:e:eprs|EPRS]]|0.464|
|[[:human genes:n:nae1|NAE1]]|0.46|
|[[:human genes:w:wars|WARS]]|0.458|
|[[:human genes:o:oip5|OIP5]]|0.458|
|[[:human genes:t:tti1|TTI1]]|0.456|
|[[:human genes:a:alg14|ALG14]]|0.45|
|[[:human genes:s:spcs2|SPCS2]]|0.449|
|[[:human genes:a:atp5j|ATP5J]]|0.449|
|[[:human genes:u:utp23|UTP23]]|0.448|
|[[:human genes:f:fnta|FNTA]]|0.446|
|[[:human genes:t:tti2|TTI2]]|0.446|
|[[:human genes:t:tsen34|TSEN34]]|0.446|
|[[:human genes:m:med4|MED4]]|0.444|
|[[:human genes:o:oraov1|ORAOV1]]|0.443|
|[[:human genes:z:znf259|ZNF259]]|0.44|
|[[:human genes:o:otud5|OTUD5]]|0.439|
|[[:human genes:c:crcp|CRCP]]|0.435|
|[[:human genes:t:tbcd|TBCD]]|0.435|
|[[:human genes:r:rad1|RAD1]]|0.434|
|[[:human genes:c:csnk2b|CSNK2B]]|0.432|
|[[:human genes:r:rpe|RPE]]|0.431|
|[[:human genes:t:ttc4|TTC4]]|0.43|
|[[:human genes:u:uba3|UBA3]]|0.43|
|[[:human genes:s:spcs3|SPCS3]]|0.426|
|[[:human genes:g:gemin6|GEMIN6]]|0.426|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.423|
|[[:human genes:g:gpn2|GPN2]]|0.422|
|[[:human genes:r:rpn1|RPN1]]|0.42|
|[[:human genes:c:cars|CARS]]|0.419|
|[[:human genes:d:ddx55|DDX55]]|0.419|
|[[:human genes:g:gtf3c1|GTF3C1]]|0.418|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.416|
|[[:human genes:l:lsm11|LSM11]]|0.416|
|[[:human genes:e:exoc3|EXOC3]]|0.416|
|[[:human genes:d:ddost|DDOST]]|0.413|
|[[:human genes:t:trnt1|TRNT1]]|0.411|
|[[:human genes:d:dhx29|DHX29]]|0.411|
|[[:human genes:p:ppp4c|PPP4C]]|0.41|
|[[:human genes:h:haus8|HAUS8]]|0.409|
|[[:human genes:v:vmp1|VMP1]]|0.409|
|[[:human genes:m:mapk14|MAPK14]]|0.409|
|[[:human genes:e:eny2|ENY2]]|0.408|
|[[:human genes:m:meaf6|MEAF6]]|0.408|
|[[:human genes:n:naf1|NAF1]]|0.408|
|[[:human genes:a:actr10|ACTR10]]|0.408|
|[[:human genes:m:mllt1|MLLT1]]|0.408|
|[[:human genes:t:tsen54|TSEN54]]|0.405|
|[[:human genes:t:tbca|TBCA]]|0.405|
|[[:human genes:c:chchd4|CHCHD4]]|0.405|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.404|
|[[:human genes:s:seh1l|SEH1L]]|0.403|
|[[:human genes:t:ten1|TEN1]]|0.403|
|[[:human genes:s:srprb|SRPRB]]|0.403|
|[[:human genes:p:pam16|PAM16]]|0.402|
|[[:human genes:s:slc35b1|SLC35B1]]|0.402|
|[[:human genes:d:dohh|DOHH]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 316
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YARS Expression in NALM6 Cells: 8.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>