======= YME1L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YME1L1
  * **<color #00a2e8>Official Name</color>**: YME1 like 1 ATPase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10730|10730]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96TA2|Q96TA2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YME1L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YME1L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607472|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:26923599, PubMed:27786171). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:18076378, PubMed:26923599, PubMed:27495975). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (PubMed:22262461). Required for normal, constitutive degradation of PRELID1 (PubMed:27495975). Catalyzes the degradation of OMA1 in response to membrane depolarization (PubMed:26923599). Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (PubMed:22262461). {ECO:0000269|PubMed:18076378, ECO:0000269|PubMed:22262461, ECO:0000269|PubMed:26923599, ECO:0000269|PubMed:27495975, ECO:0000269|PubMed:27786171}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M41|
|AAA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ATP-dependent peptidase activity|
|mitochondrial protein catabolic process|
|mitochondrial protein processing|
|protein hexamerization|
|mitochondrial calcium ion transmembrane transport|
|protein quality control for misfolded or incompletely synthesized proteins|
|metalloendopeptidase activity|
|protein processing|
|calcium ion transmembrane transport|
|protein maturation|
|calcium ion transport|
|nuclear body|
|divalent metal ion transport|
|divalent inorganic cation transport|
|mitochondrial inner membrane|
|mitochondrion organization|
|protein complex oligomerization|
|cell population proliferation|
|inorganic cation transmembrane transport|
|proteolysis involved in cellular protein catabolic process|
|cation transmembrane transport|
|cellular protein catabolic process|
|metal ion transport|
|inorganic ion transmembrane transport|
|protein catabolic process|
|cation transport|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cellular macromolecule catabolic process|
|ion transmembrane transport|
|negative regulation of cell death|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|mitochondrion|
|proteolysis|
|transmembrane transport|
|ion transport|
|ATP binding|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell death|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.74|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.72|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.76|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.79|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.81|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.82|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.89|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.89|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.93|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.05|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.06|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.09|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.15|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.17|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|2.2|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.21|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.21|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.51|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.78|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|2.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:clpb|CLPB]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|1/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1546
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YME1L1 Expression in NALM6 Cells: 7.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>