======= YWHAB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YWHAB
  * **<color #00a2e8>Official Name</color>**: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7529|7529]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31946|P31946]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YWHAB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YWHAB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601289|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|14-3-3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphoserine residue binding|
|cytoplasmic sequestering of protein|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|vacuolar membrane|
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|hippo signaling|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|phosphoprotein binding|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|negative regulation of G protein-coupled receptor signaling pathway|
|transcriptional repressor complex|
|positive regulation of establishment of protein localization to mitochondrion|
|negative regulation of protein dephosphorylation|
|regulation of mitochondrial membrane permeability|
|regulation of establishment of protein localization to mitochondrion|
|regulation of membrane permeability|
|melanosome|
|maintenance of protein location|
|protein heterooligomerization|
|negative regulation of dephosphorylation|
|histone deacetylase binding|
|positive regulation of mitochondrion organization|
|positive regulation of protein localization to membrane|
|mitochondrial membrane organization|
|regulation of protein dephosphorylation|
|regulation of G protein-coupled receptor signaling pathway|
|maintenance of location|
|positive regulation of apoptotic signaling pathway|
|regulation of mRNA stability|
|regulation of mitochondrion organization|
|regulation of RNA stability|
|regulation of protein localization to membrane|
|protein C-terminus binding|
|regulation of mRNA catabolic process|
|regulation of dephosphorylation|
|mitochondrial transport|
|protein domain specific binding|
|protein-containing complex binding|
|cadherin binding|
|positive regulation of cellular protein localization|
|regulation of mRNA metabolic process|
|enzyme binding|
|protein targeting|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|regulation of apoptotic signaling pathway|
|focal adhesion|
|mitochondrion organization|
|positive regulation of establishment of protein localization|
|protein complex oligomerization|
|posttranscriptional regulation of gene expression|
|regulation of cellular protein localization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|viral process|
|regulation of establishment of protein localization|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|membrane organization|
|regulation of cellular localization|
|protein phosphorylation|
|positive regulation of transport|
|regulation of catabolic process|
|intracellular protein transport|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|identical protein binding|
|negative regulation of protein metabolic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|negative regulation of signal transduction|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|negative regulation of gene expression|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.73|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9815
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YWHAB Expression in NALM6 Cells: 8.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>