======= ZBTB16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZBTB16
  * **<color #00a2e8>Official Name</color>**: zinc finger and BTB domain containing 16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7704|7704]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q05516|Q05516]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZBTB16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZBTB16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176797|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:14528312}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of NK T cell differentiation|
|male germ-line stem cell asymmetric division|
|germ-line stem cell division|
|germline stem cell asymmetric division|
|regulation of NK T cell differentiation|
|asymmetric stem cell division|
|asymmetric cell division|
|positive regulation of chondrocyte differentiation|
|embryonic hindlimb morphogenesis|
|positive regulation of cartilage development|
|stem cell division|
|hindlimb morphogenesis|
|forelimb morphogenesis|
|positive regulation of alpha-beta T cell differentiation|
|regulation of chondrocyte differentiation|
|transcriptional repressor complex|
|positive regulation of alpha-beta T cell activation|
|embryonic digit morphogenesis|
|positive regulation of fat cell differentiation|
|regulation of alpha-beta T cell differentiation|
|embryonic pattern specification|
|regulation of cartilage development|
|negative regulation of myeloid cell differentiation|
|positive regulation of T cell differentiation|
|positive regulation of ossification|
|mesonephros development|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|PML body|
|regulation of fat cell differentiation|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|positive regulation of leukocyte differentiation|
|limb morphogenesis|
|appendage morphogenesis|
|protein localization to nucleus|
|regulation of lymphocyte differentiation|
|cartilage development|
|limb development|
|appendage development|
|positive regulation of hemopoiesis|
|protein C-terminus binding|
|regulation of ossification|
|positive regulation of T cell activation|
|positive regulation of leukocyte cell-cell adhesion|
|anterior/posterior pattern specification|
|myeloid cell differentiation|
|connective tissue development|
|regulation of myeloid cell differentiation|
|protein domain specific binding|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|positive regulation of cell-cell adhesion|
|germ cell development|
|kidney development|
|regulation of leukocyte differentiation|
|nuclear body|
|renal system development|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|urogenital system development|
|regionalization|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of lymphocyte activation|
|post-translational protein modification|
|regulation of cell-cell adhesion|
|nuclear speck|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|sequence-specific DNA binding|
|pattern specification process|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|cell division|
|skeletal system development|
|regulation of lymphocyte activation|
|spermatogenesis|
|hemopoiesis|
|male gamete generation|
|embryonic morphogenesis|
|protein-containing complex|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|protein ubiquitination|
|gamete generation|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|protein localization to organelle|
|protein modification by small protein conjugation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|apoptotic process|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|programmed cell death|
|identical protein binding|
|cell death|
|positive regulation of immune system process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp534|Trientine 500μM R08 exp534]]|-2|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7257
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZBTB16 Expression in NALM6 Cells: 2.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>