======= ZBTB20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZBTB20
  * **<color #00a2e8>Official Name</color>**: zinc finger and BTB domain containing 20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26137|26137]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HC78|Q9HC78]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZBTB20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZBTB20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606025|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (PubMed:11352661). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). {ECO:0000250|UniProtKB:Q8K0L9, ECO:0000269|PubMed:11352661}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTB|
|zf-C2H2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of glycolytic process|
|positive regulation of interferon-beta production|
|positive regulation of ATP metabolic process|
|positive regulation of purine nucleotide metabolic process|
|positive regulation of nucleotide metabolic process|
|regulation of interferon-beta production|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|positive regulation of type I interferon production|
|regulation of glycolytic process|
|positive regulation of lipid biosynthetic process|
|positive regulation of carbohydrate metabolic process|
|cellular response to carbohydrate stimulus|
|positive regulation of tumor necrosis factor production|
|regulation of carbohydrate catabolic process|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|cellular glucose homeostasis|
|positive regulation of interleukin-6 production|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|regulation of type I interferon production|
|lipid homeostasis|
|response to glucose|
|positive regulation of small molecule metabolic process|
|regulation of interleukin-6 production|
|positive regulation of lipid metabolic process|
|response to hexose|
|regulation of tumor necrosis factor production|
|response to monosaccharide|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of generation of precursor metabolites and energy|
|response to carbohydrate|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of lipid biosynthetic process|
|regulation of carbohydrate metabolic process|
|transcription regulatory region DNA binding|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|nuclear body|
|positive regulation of cellular catabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|positive regulation of cytokine production|
|regulation of cytokine production|
|cellular chemical homeostasis|
|regulation of cellular catabolic process|
|negative regulation of transcription by RNA polymerase II|
|cellular homeostasis|
|regulation of catabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|homeostatic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10937
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZBTB20 Expression in NALM6 Cells: 2.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>