======= ZCCHC8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZCCHC8
  * **<color #00a2e8>Official Name</color>**: zinc finger CCHC-type containing 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55596|55596]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6NZY4|Q6NZY4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZCCHC8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZCCHC8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616381|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non- coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). May be involved in pre-mRNA splicing (Probable). {ECO:0000269|PubMed:27871484, ECO:0000305|PubMed:16263084}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-CCHC|
|PSP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TRAMP complex|
|catalytic step 2 spliceosome|
|nuclear body|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|zinc ion binding|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-2.08|
|[[:results:exp539|42°C R08 exp539]]|-1.97|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.87|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.81|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.79|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.74|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.72|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.72|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.74|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.74|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.75|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.82|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.84|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.85|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.86|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.91|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.91|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.92|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.95|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.96|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.98|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.02|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.07|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.14|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.3|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.36|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.53|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.57|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.77|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|3.16|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|3.29|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rbm7|RBM7]]|0.616|
|[[:human genes:z:zfc3h1|ZFC3H1]]|0.466|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6777
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZCCHC8 Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>