======= ZDHHC5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZDHHC5
  * **<color #00a2e8>Official Name</color>**: zinc finger DHHC-type palmitoyltransferase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25921|25921]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9C0B5|Q9C0B5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZDHHC5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZDHHC5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614586|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity). {ECO:0000250, ECO:0000269|PubMed:21820437}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-DHHC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|palmitoyltransferase activity|
|protein-cysteine S-palmitoyltransferase activity|
|protein palmitoylation|
|protein lipidation|
|lipoprotein biosynthetic process|
|lipoprotein metabolic process|
|protein acylation|
|dendrite|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp358|FK-506 5μM R07 exp358]]|-2.56|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-2.12|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.11|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.04|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.99|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.92|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.9|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.76|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.74|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.73|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.73|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.72|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.73|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.76|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.78|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.85|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.99|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6360
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZDHHC5 Expression in NALM6 Cells: 6.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>