======= ZFPM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZFPM2
  * **<color #00a2e8>Official Name</color>**: zinc finger protein, FOG family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23414|23414]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WW38|Q8WW38]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZFPM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZFPM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603693|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity). {ECO:0000250, ECO:0000269|PubMed:10438528}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|right ventricular cardiac muscle tissue morphogenesis|
|negative regulation of female gonad development|
|negative regulation of gonad development|
|positive regulation of male gonad development|
|gonadal mesoderm development|
|regulation of male gonad development|
|positive regulation of gonad development|
|regulation of female gonad development|
|regulation of gonad development|
|cardiac right ventricle morphogenesis|
|positive regulation of cardiac muscle cell proliferation|
|outflow tract septum morphogenesis|
|positive regulation of cardiac muscle tissue growth|
|positive regulation of heart growth|
|regulation of cardiac muscle cell proliferation|
|ventricular septum morphogenesis|
|positive regulation of cardiac muscle tissue development|
|negative regulation of fat cell differentiation|
|positive regulation of organ growth|
|ventricular cardiac muscle tissue morphogenesis|
|ventricular cardiac muscle tissue development|
|negative regulation of reproductive process|
|regulation of cardiac muscle tissue growth|
|RNA polymerase II transcription factor binding|
|regulation of heart growth|
|vasculogenesis|
|cardiac muscle tissue morphogenesis|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|positive regulation of muscle tissue development|
|ventricular septum development|
|cardiac ventricle morphogenesis|
|outflow tract morphogenesis|
|cardiac septum morphogenesis|
|positive regulation of reproductive process|
|regulation of cardiac muscle tissue development|
|muscle tissue morphogenesis|
|muscle organ morphogenesis|
|regulation of organ growth|
|cardiac septum development|
|regulation of fat cell differentiation|
|mesoderm development|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|regulation of reproductive process|
|cardiac muscle tissue development|
|lung development|
|cardiac chamber development|
|positive regulation of developmental growth|
|respiratory tube development|
|respiratory system development|
|gonad development|
|development of primary sexual characteristics|
|mesenchyme development|
|transcription corepressor activity|
|heart morphogenesis|
|positive regulation of growth|
|sex differentiation|
|transcription coactivator activity|
|striated muscle tissue development|
|blood coagulation|
|coagulation|
|muscle organ development|
|muscle tissue development|
|hemostasis|
|regulation of developmental growth|
|transcription factor binding|
|in utero embryonic development|
|blood vessel morphogenesis|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|muscle structure development|
|wound healing|
|blood vessel development|
|regulation of body fluid levels|
|vasculature development|
|cardiovascular system development|
|heart development|
|tissue morphogenesis|
|response to wounding|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell differentiation|
|zinc ion binding|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|negative regulation of cell death|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.16|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16673
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZFPM2 Expression in NALM6 Cells: 1.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>