======= ZFY =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZFY
  * **<color #00a2e8>Official Name</color>**: zinc finger protein Y-linked
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7544|7544]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08048|P08048]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZFY&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZFY|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/490000|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'. {ECO:0000269|PubMed:20028140}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Zfx Zfy act|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleolus|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-3.38|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.85|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.54|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.3|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.14|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-2.13|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.11|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.06|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.99|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.94|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.92|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.89|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.78|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.75|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.75|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.74|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.74|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.73|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.7|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.72|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.74|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.77|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.81|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.87|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.87|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.92|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.02|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2.04|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.08|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.08|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.2|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.37|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.51|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.68|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.73|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.75|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|3.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13537
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZFY Expression in NALM6 Cells: 4.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>