======= ZFYVE20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBSN
  * **<color #00a2e8>Official Name</color>**: rabenosyn, RAB effector
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64145|64145]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H1K0|Q9H1K0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZFYVE20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZFYVE20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609511|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FYVE|
|Rbsn|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi to lysosome transport|
|early endosome to Golgi transport|
|Golgi to vacuole transport|
|regulation of Golgi organization|
|retrograde transport, endosome to Golgi|
|post-Golgi vesicle-mediated transport|
|lysosomal transport|
|vacuolar transport|
|cytosolic transport|
|Rab GTPase binding|
|early endosome membrane|
|nucleic acid binding|
|endosome membrane|
|endosomal transport|
|endosome|
|blood coagulation|
|coagulation|
|hemostasis|
|Golgi vesicle transport|
|wound healing|
|regulation of body fluid levels|
|response to wounding|
|intracellular membrane-bounded organelle|
|zinc ion binding|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.79|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.6|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.4|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-2.12|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-2.04|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.03|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.93|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.89|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.87|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.87|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.79|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.78|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.73|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.73|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.71|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.73|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.76|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.77|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.82|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.94|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2614
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZFYVE20 Expression in NALM6 Cells: 5.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>