======= ZMYM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZMYM2
  * **<color #00a2e8>Official Name</color>**: zinc finger MYM-type containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7750|7750]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBW7|Q9UBW7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZMYM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZMYM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602221|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3504|
|zf-FCS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin conjugating enzyme binding|
|PML body|
|regulation of cell morphogenesis|
|zinc ion binding|
|regulation of anatomical structure morphogenesis|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.46|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-2.44|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.26|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.24|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.2|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-2.16|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.04|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.99|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.92|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.91|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.9|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.86|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.83|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.82|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.8|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.76|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.75|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.73|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.78|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.79|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.82|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.9|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.92|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.05|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.2|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:asb7|ASB7]]|0.529|
|[[:human genes:i:id3|ID3]]|0.527|
|[[:human genes:s:ssbp2|SSBP2]]|0.498|
|[[:human genes:a:asxl2|ASXL2]]|0.481|
|[[:human genes:n:nsd1|NSD1]]|0.462|
|[[:human genes:m:maml1|MAML1]]|0.453|
|[[:human genes:c:cbx3|CBX3]]|0.451|
|[[:human genes:b:bap1|BAP1]]|0.434|
|[[:human genes:c:cbfb|CBFB]]|0.428|
|[[:human genes:z:znf706|ZNF706]]|0.42|
|[[:human genes:r:runx1|RUNX1]]|0.417|
|[[:human genes:t:trim33|TRIM33]]|0.415|
|[[:human genes:m:mef2c|MEF2C]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7646
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZMYM2 Expression in NALM6 Cells: 7.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>