======= ZNF202 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF202
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 202
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7753|7753]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95125|O95125]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF202&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF202|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603430|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KRAB|
|SCAN|
|zf-C2H2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|transcription by RNA polymerase II|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|negative regulation of transcription by RNA polymerase II|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|lipid metabolic process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-2.37|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2.26|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.24|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.1|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.07|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-2.01|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.93|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.88|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.87|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.85|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.82|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.79|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.79|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.78|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.72|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|1.77|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.9|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13338
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF202 Expression in NALM6 Cells: 5.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>