======= ZNF219 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF219
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 219
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51222|51222]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P2Y4|Q9P2Y4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF219&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF219|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605036|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the Kruppel-like zinc finger gene family. The encoded protein functions as a transcriptional repressor of the high mobility group nucleosome binding domain 1 protein, which is associated with transcriptionally active chromatin. [provided by RefSeq, Apr 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q6IQX8, ECO:0000269|PubMed:14621294, ECO:0000269|PubMed:19549071}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histamine receptor activity|
|limb bud formation|
|positive regulation of chondrocyte differentiation|
|positive regulation of cartilage development|
|regulation of chondrocyte differentiation|
|regulation of cartilage development|
|limb morphogenesis|
|appendage morphogenesis|
|limb development|
|appendage development|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|regulation of neurotransmitter levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|negative regulation of transcription by RNA polymerase II|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell differentiation|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-2.22|
|[[:results:exp539|42°C R08 exp539]]|-1.74|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.74|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.7|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.74|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.79|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.82|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.96|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.99|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|2.14|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.18|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.486|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.465|
|[[:human genes:c:c14orf93|C14orf93]]|0.461|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.461|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.45|
|[[:human genes:c:cgb2|CGB2]]|0.445|
|[[:human genes:v:vasn|VASN]]|0.44|
|[[:human genes:r:rrn3|RRN3]]|0.437|
|[[:human genes:n:napa|NAPA]]|0.436|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.435|
|[[:human genes:z:zmat5|ZMAT5]]|0.433|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.429|
|[[:human genes:t:trim52|TRIM52]]|0.42|
|[[:human genes:n:ncapg|NCAPG]]|0.418|
|[[:human genes:t:tceb3c|TCEB3C]]|0.417|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.415|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.415|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.415|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.415|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.413|
|[[:human genes:w:wdr87|WDR87]]|0.413|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.411|
|[[:human genes:b:brix1|BRIX1]]|0.409|
|[[:human genes:p:psmb2|PSMB2]]|0.408|
|[[:human genes:a:akirin2|AKIRIN2]]|0.405|
|[[:human genes:r:rps7|RPS7]]|0.402|
|[[:human genes:r:rfxank|RFXANK]]|0.401|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2422
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF219 Expression in NALM6 Cells: 3.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>