======= ZNF410 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF410
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 410
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57862|57862]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86VK4|Q86VK4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF410&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF410|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619427|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence. {ECO:0000269|PubMed:12370286}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.08|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.08|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.07|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.07|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-2.05|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.04|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.98|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.95|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.94|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.88|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.86|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.78|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.77|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.76|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.76|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.21|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:scaf8|SCAF8]]|0.522|
|[[:human genes:s:ssbp2|SSBP2]]|0.456|
|[[:human genes:x:xpo6|XPO6]]|0.44|
|[[:human genes:l:ldb1|LDB1]]|0.435|
|[[:human genes:c:cbfb|CBFB]]|0.426|
|[[:human genes:c:ccdc101|CCDC101]]|0.425|
|[[:human genes:a:ago2|AGO2]]|0.415|
|[[:human genes:l:lyl1|LYL1]]|0.406|
|[[:human genes:l:lmo2|LMO2]]|0.405|
|[[:human genes:o:otud5|OTUD5]]|0.404|
|[[:human genes:t:taf5l|TAF5L]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13897
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF410 Expression in NALM6 Cells: 5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>