======= ZNF655 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF655
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 655
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79027|79027]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N720|Q8N720]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF655&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF655|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617891|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KRAB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of G1/S transition of mitotic cell cycle|
|negative regulation of cell cycle G1/S phase transition|
|regulation of G1/S transition of mitotic cell cycle|
|regulation of cell cycle G1/S phase transition|
|negative regulation of mitotic cell cycle phase transition|
|negative regulation of cell cycle phase transition|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|negative regulation of cell cycle|
|regulation of mitotic cell cycle|
|regulation of cell cycle process|
|molecular function|
|nucleolus|
|regulation of cell cycle|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.76|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.8|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.8|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:ticrr|TICRR]]|0.518|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.517|
|[[:human genes:s:supt6h|SUPT6H]]|0.515|
|[[:human genes:p:psmb4|PSMB4]]|0.508|
|[[:human genes:c:copb1|COPB1]]|0.5|
|[[:human genes:r:rpl34|RPL34]]|0.497|
|[[:human genes:d:dtl|DTL]]|0.496|
|[[:human genes:s:snrpa1|SNRPA1]]|0.493|
|[[:human genes:n:nupl1|NUPL1]]|0.492|
|[[:human genes:p:prim1|PRIM1]]|0.491|
|[[:human genes:s:supt5h|SUPT5H]]|0.489|
|[[:human genes:p:psma6|PSMA6]]|0.486|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.485|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.479|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.479|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.478|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.478|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.478|
|[[:human genes:f:fbxo5|FBXO5]]|0.476|
|[[:human genes:r:rpl35|RPL35]]|0.476|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.471|
|[[:human genes:z:znf106|ZNF106]]|0.469|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.469|
|[[:human genes:v:vasn|VASN]]|0.465|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.462|
|[[:human genes:z:znf830|ZNF830]]|0.462|
|[[:human genes:s:stil|STIL]]|0.457|
|[[:human genes:t:twistnb|TWISTNB]]|0.457|
|[[:human genes:c:copg1|COPG1]]|0.456|
|[[:human genes:c:cope|COPE]]|0.454|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.454|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.45|
|[[:human genes:r:rps2|RPS2]]|0.449|
|[[:human genes:c:c14orf93|C14orf93]]|0.448|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.447|
|[[:human genes:c:copz1|COPZ1]]|0.445|
|[[:human genes:a:aamp|AAMP]]|0.444|
|[[:human genes:g:gosr2|GOSR2]]|0.441|
|[[:human genes:c:cbwd3|CBWD3]]|0.44|
|[[:human genes:p:pola2|POLA2]]|0.44|
|[[:human genes:p:polr2j3|POLR2J3]]|0.439|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.439|
|[[:human genes:r:rad51|RAD51]]|0.438|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.437|
|[[:human genes:p:psmc2|PSMC2]]|0.437|
|[[:human genes:a:ankle2|ANKLE2]]|0.436|
|[[:human genes:n:npipb5|NPIPB5]]|0.436|
|[[:human genes:t:tspy8|TSPY8]]|0.436|
|[[:human genes:c:chd4|CHD4]]|0.436|
|[[:human genes:n:nup160|NUP160]]|0.436|
|[[:human genes:c:cbwd5|CBWD5]]|0.435|
|[[:human genes:p:psmc1|PSMC1]]|0.435|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.435|
|[[:human genes:e:exosc3|EXOSC3]]|0.435|
|[[:human genes:u:utp3|UTP3]]|0.434|
|[[:human genes:c:copb2|COPB2]]|0.434|
|[[:human genes:p:prpf8|PRPF8]]|0.433|
|[[:human genes:n:naaladl1|NAALADL1]]|0.433|
|[[:human genes:m:myo1h|MYO1H]]|0.433|
|[[:human genes:t:tceb3c|TCEB3C]]|0.432|
|[[:human genes:a:acsf2|ACSF2]]|0.431|
|[[:human genes:p:psmb3|PSMB3]]|0.431|
|[[:human genes:u:upf1|UPF1]]|0.428|
|[[:human genes:g:gar1|GAR1]]|0.428|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.428|
|[[:human genes:r:rrn3|RRN3]]|0.426|
|[[:human genes:v:vps54|VPS54]]|0.426|
|[[:human genes:p:pwp2|PWP2]]|0.425|
|[[:human genes:s:sart1|SART1]]|0.425|
|[[:human genes:c:cbwd6|CBWD6]]|0.424|
|[[:human genes:c:ccna2|CCNA2]]|0.424|
|[[:human genes:s:slc4a1|SLC4A1]]|0.424|
|[[:human genes:p:pcf11|PCF11]]|0.423|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.423|
|[[:human genes:m:med17|MED17]]|0.423|
|[[:human genes:k:krt78|KRT78]]|0.423|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.422|
|[[:human genes:o:orc1|ORC1]]|0.422|
|[[:human genes:a:arcn1|ARCN1]]|0.422|
|[[:human genes:p:psmd3|PSMD3]]|0.422|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.422|
|[[:human genes:p:paf1|PAF1]]|0.42|
|[[:human genes:p:pan3|PAN3]]|0.42|
|[[:human genes:c:ciapin1|CIAPIN1]]|0.42|
|[[:human genes:t:traip|TRAIP]]|0.419|
|[[:human genes:c:chaf1a|CHAF1A]]|0.418|
|[[:human genes:n:narfl|NARFL]]|0.418|
|[[:human genes:g:golga8o|GOLGA8O]]|0.417|
|[[:human genes:r:rrp15|RRP15]]|0.417|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.417|
|[[:human genes:d:ddtl|DDTL]]|0.416|
|[[:human genes:r:rnf4|RNF4]]|0.414|
|[[:human genes:n:nfatc4|NFATC4]]|0.413|
|[[:human genes:c:cactin|CACTIN]]|0.412|
|[[:human genes:c:clcn6|CLCN6]]|0.412|
|[[:human genes:f:fbxw9|FBXW9]]|0.412|
|[[:human genes:n:nup153|NUP153]]|0.412|
|[[:human genes:m:mt1e|MT1E]]|0.411|
|[[:human genes:c:cgb2|CGB2]]|0.41|
|[[:human genes:p:plxnb3|PLXNB3]]|0.409|
|[[:human genes:c:cep192|CEP192]]|0.409|
|[[:human genes:k:kctd17|KCTD17]]|0.409|
|[[:human genes:c:ccdc94|CCDC94]]|0.409|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.408|
|[[:human genes:p:pole|POLE]]|0.408|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.408|
|[[:human genes:r:rad21|RAD21]]|0.408|
|[[:human genes:b:bod1l1|BOD1L1]]|0.408|
|[[:human genes:s:sf3a1|SF3A1]]|0.407|
|[[:human genes:c:copa|COPA]]|0.407|
|[[:human genes:s:sec13|SEC13]]|0.407|
|[[:human genes:d:dock6|DOCK6]]|0.407|
|[[:human genes:t:tfip11|TFIP11]]|0.407|
|[[:human genes:m:mki67ip|MKI67IP]]|0.406|
|[[:human genes:c:cnot1|CNOT1]]|0.406|
|[[:human genes:t:terf1|TERF1]]|0.405|
|[[:human genes:a:ankle1|ANKLE1]]|0.405|
|[[:human genes:p:psmd1|PSMD1]]|0.404|
|[[:human genes:n:nop16|NOP16]]|0.404|
|[[:human genes:x:xylt2|XYLT2]]|0.403|
|[[:human genes:n:nhp2l1|NHP2L1]]|0.403|
|[[:human genes:r:ranbp2|RANBP2]]|0.403|
|[[:human genes:c:cdc6|CDC6]]|0.402|
|[[:human genes:p:ppm1d|PPM1D]]|0.401|
|[[:human genes:n:nup85|NUP85]]|0.401|
|[[:human genes:s:sf3a3|SF3A3]]|0.4|
|[[:human genes:z:zfand5|ZFAND5]]|0.4|
|[[:human genes:d:dido1|DIDO1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2272
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF655 Expression in NALM6 Cells: 6.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>