======= ZNF681 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF681
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 681
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=148213|148213]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96N22|Q96N22]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF681&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF681|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in transcriptional regulation. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C2H2|
|KRAB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-2.18|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-2.18|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.81|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.77|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.81|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.84|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.87|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.89|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.92|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.95|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.98|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.01|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.02|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|2.06|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.31|
|[[:results:exp132|Metformin 40μM R03 exp132]]|2.31|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|2.33|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|2.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10648
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF681 Expression in NALM6 Cells: 5.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>