======= ZNF718 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF718
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 718
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=255403|255403]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q3SXZ3|Q3SXZ3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF718&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF718|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in transcriptional regulation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C2H2|
|KRAB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-2.33|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.94|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.83|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.72|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.72|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.75|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.76|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|1.82|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.88|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.9|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.94|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19053
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF718 Expression in NALM6 Cells: 1.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>