======= ZNF737 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF737
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 737
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=100129842|100129842]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75373|O75373]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF737&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF737|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603984|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in transcriptional regulation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C2H2|
|KRAB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleic acid binding|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.89|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.39|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.07|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.96|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.86|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.73|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.7|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|1.72|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.75|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.76|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.78|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.84|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.85|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.87|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.93|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|2.03|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.1|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.2|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9924
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF737 Expression in NALM6 Cells: 3.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>