======= ZNF91 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF91
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 91
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7644|7644]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q05481|Q05481]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF91&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF91|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603971|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo (PubMed:11470777). {ECO:0000269|PubMed:25274305, ECO:0000305|PubMed:11470777}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KRAB|
|zf-C2H2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of transposon integration|
|negative regulation of transposon integration|
|regulation of transposition|
|negative regulation of transposition|
|negative regulation of DNA metabolic process|
|regulation of DNA metabolic process|
|DNA-binding transcription factor activity|
|zinc ion binding|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.47|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.23|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.9|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.74|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.7|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.7|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.77|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.82|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.98|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.02|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|2.08|
|[[:results:exp302|35°C R06 exp302]]|2.15|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.23|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|2.27|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|2.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8581
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF91 Expression in NALM6 Cells: 5.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>