======= ZNRD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNRD1
  * **<color #00a2e8>Official Name</color>**: zinc ribbon domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=30834|30834]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P1U0|Q9P1U0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNRD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNRD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TFIIS C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase I activity|
|RNA polymerase I complex|
|mRNA cleavage|
|transcription elongation from RNA polymerase I promoter|
|termination of RNA polymerase I transcription|
|DNA-directed 5-3 RNA polymerase activity|
|transcription initiation from RNA polymerase I promoter|
|transcription by RNA polymerase I|
|positive regulation of gene expression, epigenetic|
|DNA-templated transcription, termination|
|DNA-templated transcription, elongation|
|RNA phosphodiester bond hydrolysis|
|nucleic acid binding|
|DNA-templated transcription, initiation|
|regulation of gene expression, epigenetic|
|nucleic acid phosphodiester bond hydrolysis|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|zinc ion binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 351/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|13/28|
|blood|5/28|
|bone|6/25|
|breast|18/33|
|central nervous system|34/56|
|cervix|2/4|
|colorectal|7/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|5/15|
|kidney|15/21|
|liver|9/20|
|lung|34/75|
|lymphocyte|7/14|
|ovary|13/26|
|pancreas|12/24|
|peripheral nervous system|6/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|8/24|
|soft tissue|4/7|
|thyroid|1/2|
|upper aerodigestive|13/22|
|urinary tract|19/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1862
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNRD1 Expression in NALM6 Cells: 4.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>