======= ZP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZP4
  * **<color #00a2e8>Official Name</color>**: zona pellucida glycoprotein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57829|57829]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12836|Q12836]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613514|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Zona pellucida|
|Trefoil|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of binding of sperm to zona pellucida|
|acrosin binding|
|regulation of binding of sperm to zona pellucida|
|negative regulation of fertilization|
|acrosomal vesicle exocytosis|
|positive regulation of acrosome reaction|
|positive regulation of fertilization|
|positive regulation of humoral immune response|
|regulation of acrosome reaction|
|acrosome reaction|
|regulation of fertilization|
|binding of sperm to zona pellucida|
|calcium-ion regulated exocytosis|
|sperm-egg recognition|
|negative regulation of reproductive process|
|cell-cell recognition|
|positive regulation of reproductive process|
|positive regulation of T cell proliferation|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|regulation of humoral immune response|
|positive regulation of leukocyte proliferation|
|single fertilization|
|regulation of T cell proliferation|
|regulation of reproductive process|
|fertilization|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|negative regulation of multi-organism process|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|cell recognition|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|positive regulation of lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|regulation of cell activation|
|regulation of cell adhesion|
|regulated exocytosis|
|regulation of multi-organism process|
|exocytosis|
|sexual reproduction|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|multi-organism reproductive process|
|secretion by cell|
|export from cell|
|identical protein binding|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|reproductive process|
|reproduction|
|regulation of cell population proliferation|
|regulation of immune system process|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8538
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZP4 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>