======= ZSWIM7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZSWIM7
  * **<color #00a2e8>Official Name</color>**: zinc finger SWIM-type containing 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=125150|125150]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q19AV6|Q19AV6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZSWIM7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZSWIM7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614535|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. {ECO:0000269|PubMed:16710300, ECO:0000269|PubMed:21965664}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SWIM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Shu complex|
|double-strand break repair via homologous recombination|
|recombinational repair|
|protein stabilization|
|double-strand break repair|
|DNA recombination|
|regulation of protein stability|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|zinc ion binding|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-3.17|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-3.16|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-3.09|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-2.67|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.95|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.8|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:swsap1|SWSAP1]]|0.528|
|[[:human genes:s:spidr|SPIDR]]|0.417|
|[[:human genes:r:rnf168|RNF168]]|0.402|
|[[:human genes:m:mcm9|MCM9]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8053
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZSWIM7 Expression in NALM6 Cells: 4.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>