======= ZW10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZW10
  * **<color #00a2e8>Official Name</color>**: zw10 kinetochore protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9183|9183]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43264|O43264]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZW10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZW10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603954|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241). {ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15029241, ECO:0000269|PubMed:15094189, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Zw10|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Dsl1/NZR complex|
|RZZ complex|
|centromeric DNA binding|
|kinetochore microtubule|
|protein localization to kinetochore|
|protein localization to chromosome, centromeric region|
|regulation of exit from mitosis|
|spindle assembly checkpoint|
|mitotic spindle checkpoint|
|mitotic spindle assembly checkpoint|
|spindle checkpoint|
|negative regulation of mitotic metaphase/anaphase transition|
|negative regulation of metaphase/anaphase transition of cell cycle|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|establishment of mitotic spindle orientation|
|negative regulation of mitotic sister chromatid segregation|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|establishment of mitotic spindle localization|
|establishment of spindle orientation|
|negative regulation of mitotic nuclear division|
|establishment of spindle localization|
|mitotic metaphase plate congression|
|negative regulation of nuclear division|
|spindle localization|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|metaphase plate congression|
|regulation of mitotic sister chromatid separation|
|protein localization to chromosome|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|establishment of chromosome localization|
|chromosome localization|
|regulation of sister chromatid segregation|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|kinetochore|
|condensed chromosome kinetochore|
|regulation of chromosome segregation|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|establishment of cell polarity|
|spindle pole|
|Golgi organization|
|negative regulation of chromosome organization|
|sister chromatid segregation|
|mitotic nuclear division|
|mitotic cell cycle checkpoint|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|cell cycle checkpoint|
|establishment or maintenance of cell polarity|
|negative regulation of mitotic cell cycle phase transition|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|nuclear chromosome segregation|
|meiotic cell cycle|
|negative regulation of cell cycle phase transition|
|chromosome segregation|
|nuclear division|
|negative regulation of mitotic cell cycle|
|organelle fission|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|establishment of organelle localization|
|Golgi vesicle transport|
|negative regulation of organelle organization|
|regulation of mitotic cell cycle phase transition|
|endomembrane system organization|
|regulation of cell cycle phase transition|
|microtubule cytoskeleton organization|
|cell division|
|negative regulation of cell cycle|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|protein localization to organelle|
|regulation of cell cycle process|
|endoplasmic reticulum membrane|
|cell cycle process|
|endoplasmic reticulum|
|chromosome organization|
|cytoskeleton organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-2.21|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.2|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.14|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.11|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.09|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.93|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.83|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.83|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.81|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.7|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.74|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|3.65|
|[[:results:exp17|DABN 20μM R00 exp17]]|4.17|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|6.12|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|6.17|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|6.67|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|7.05|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|7.42|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|8.03|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|8.09|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|8.24|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|8.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kntc1|KNTC1]]|0.871|
|[[:human genes:m:mad1l1|MAD1L1]]|0.807|
|[[:human genes:t:trip13|TRIP13]]|0.789|
|[[:human genes:m:mad2l1|MAD2L1]]|0.788|
|[[:human genes:b:bub1b|BUB1B]]|0.783|
|[[:human genes:z:zwilch|ZWILCH]]|0.776|
|[[:human genes:m:mad2l1bp|MAD2L1BP]]|0.743|
|[[:human genes:r:rbm14|RBM14]]|0.72|
|[[:human genes:b:bub3|BUB3]]|0.707|
|[[:human genes:c:cdc20|CDC20]]|0.61|
|[[:human genes:f:fnta|FNTA]]|0.499|
|[[:human genes:f:fntb|FNTB]]|0.476|
|[[:human genes:c:ccnb1|CCNB1]]|0.459|
|[[:human genes:c:cenpe|CENPE]]|0.458|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 32/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|3/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2120
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZW10 Expression in NALM6 Cells: 5.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>