====== Results ======
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Displaying **413** screens.
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* Unique Compounds: **295**
* Combinations: **7**
* Proteins: ** 8**
* Conditions: ** 5**
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^Substance/Condition^Experiments^Description/Target Mechanism^Classification^
|5-Fluorouracil|[[results:exp1|exp1 (2µM)]]\\ [[results:exp2|exp2 (20µM)]]|Thymidylate synthase inhibitor, blocks DNA replication|**Class / Subclass 1: ** Metabolism / Antimetabolite\\ **Class / Subclass 2: ** DNA Damage, Repair and Replication / Replication Inhibitor|
|Actinomycin D|[[results:exp3|exp3 (1nM)]]\\ [[results:exp4|exp4 (10nM)]]|Inhibits RNA polymerases, intercalates DNA, prevents chain elongation|**Class / Subclass 1: ** Gene Regulation / Transcription Inhibitor|
|α-Amanitin|[[results:exp5|exp5 (500nM)]]|Inhibits RNA polymerase II and III, interferes with translocation|**Class / Subclass 1: ** Gene Regulation / Transcription Inhibitor\\ **Class / Subclass 2: ** Environmental Stresses / Toxin|
|Bortezomib|[[results:exp6|exp6 (5nM)]]\\ [[results:exp7|exp7 (50nM)]]|Inhibits 26S proteasome, binds reversibly to chymotrypsin-like catalytic sites|**Class / Subclass 1: ** Proteostasis / Proteasome Inhibitor|
|Brefeldin A|[[results:exp8|exp8 (20nM)]]|Inhibits Golgi to ER transport, forms uncompetitive complex with GBF1 and GDP-bound Arf1|**Class / Subclass 1: ** Organelle Function / Vesicule Trafficking Inhibitor|
|Carbonyl cyanide 3-chlorophenylhydrazone|[[results:exp10|exp10 (100nM)]]\\ [[results:exp11|exp11 (1µM)]]|Mitochondrial proton gradient uncoupler, disrupts ATP synthesis|**Class / Subclass 1: ** Organelle Function / Mitochondrial Inhibitor|
|Chloramphenicol|[[results:exp12|exp12 (2µM)]]\\ [[results:exp13|exp13 (20µM)]]|Binds 23S rRNA of 50S ribosomal subunit, inhibits protein synthesis|**Class / Subclass 1: ** Infectious Disease / Antibiotic\\ **Class / Subclass 2: ** Organelle Function / Mitochondrial Inhibitor|
|Cycloheximide|[[results:exp14|exp14 (20nM)]]\\ [[results:exp15|exp15 (200nM)]]|Translation elongation inhibitor, binds 60S ribosomal subunit|**Class / Subclass 1: ** Proteostasis / Translation Inhibitor\\ **Class / Subclass 2: ** Environmental Stresses / Toxin|
|DABN|[[results:exp16|exp16 (2µM)]]\\ [[results:exp17|exp17 (20µM)]]|Unknown|**Class / Subclass 1: ** Uncharacterized Mechanism / Chemical Screen Hit|
|Doxycycline|[[results:exp18|exp18 (10µM)]]|Inhibits bacterial 30S ribosome, also used in tet-on/tet-off gene expression control|**Class / Subclass 1: ** Infectious Disease / Antibiotic\\ **Class / Subclass 2: ** Organelle Function / Mitochondrial Inhibitor|
|Etoposide|[[results:exp19|exp19 (1µM)]]\\ [[results:exp20|exp20 (10µM)]]\\ [[results:exp198|exp198 (100nM)]]\\ [[results:exp199|exp199 (300nM)]]|Binds DNA-TopII complex, blocks re-ligation, induces strand breaks, semi-synthetic derivative of podophyllotoxin|**Class / Subclass 1: ** DNA Damage, Repair and Replication / Topoisomerase II Inhibitor|
|MLN-4924|[[results:exp21|exp21 (200nM)]]\\ [[results:exp22|exp22 (2µM)]]|Inhibits NEDD8-activating enzyme (NAE), prevents activity of cullin-RING ligase (CRL) E3 enzymes|**Class / Subclass 1: ** Proteostasis / NEDDylation Inhibitor|
|Nocodazole|[[results:exp23|exp23 (20nM)]]\\ [[results:exp24|exp24 (200nM)]]\\ [[results:exp64|exp64 (200nM)]]\\ [[results:exp94|exp94 (100nM)]]|Inhibits microtubule polymerization and mitotic spindle formation, induces spindle assembly checkpoint (SAC)|**Class / Subclass 1: ** Cell Cycle / Microtubule Poison\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor|
|Oligomycin A|[[results:exp25|exp25 (2µM)]]\\ [[results:exp26|exp26 (20µM)]]|Inhibits F0 proton channel of mitochondrial ATP synthase, blocks electron flow through ETC|**Class / Subclass 1: ** Organelle Function / Mitochondrial Inhibitor|
|Pimelic Diphenylamide 106|[[results:exp27|exp27 (500nM)]]\\ [[results:exp28|exp28 (5µM)]]|Inhibits HDAC3 selectively, benzamide derivative|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|Rapamycin|[[results:exp307|exp307 (2µM + 3µM Cyclosporin A)]]\\ [[results:exp429|exp429 (1nM)]]\\ [[results:exp308|exp308 (2µM + 5µM FK-506)]]\\ [[results:exp29|exp29 (1µM)]]\\ [[results:exp30|exp30 (10µM)]]\\ [[results:exp306|exp306 (2µM)]]|Allosteric mTORC1 inhibitor, forms ternary complex with FKBP12 and mTOR, attenuates protein synthesis and metabolism|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor\\ **Class / Subclass 2: ** Proteostasis / mTOR inhibitor|
|Rifampicin|[[results:exp430|exp430 (30µM)]]\\ [[results:exp31|exp31 (1µM)]]\\ [[results:exp32|exp32 (10µM)]]|Inhibits bacterial RNA polymerase, induces hepatic cytochrome P450 enzymes|**Class / Subclass 1: ** Infectious Disease / Antibiotic|
|Rotenone|[[results:exp431|exp431 (70nM)]]\\ [[results:exp33|exp33 (2µM)]]\\ [[results:exp34|exp34 (20µM)]]|Inhibits complex I, blocks electron transfer from iron-sulfur centers to ubiquinone, generates ROS, also inhibits microtubule assembly|**Class / Subclass 1: ** Organelle Function / Mitochondrial Inhibitor\\ **Class / Subclass 2: ** Cell Cycle / Microtubule Poison|
|TRAIL|[[results:exp35|exp35 (5ng/mL)]]\\ [[results:exp36|exp36 (50ng/mL)]]|TNF-related apoptosis-inducing ligand, TNF superfamily member, induces extrinsic apoptosis|**Class / Subclass 1: ** Signal Transduction / Other Receptor Agonist|
|Wortmannin|[[results:exp37|exp37 (500nM)]]\\ [[results:exp38|exp38 (5µM)]]|Inhibits PI3K and PI3K-related enzymes, non-specific covalent inhibitor|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor\\ **Class / Subclass 2: ** Proteostasis / Autophagy Inhibitor|
|2-Methoxyestradiol|[[results:exp310|exp310 (550nM)]]\\ [[results:exp311|exp311 (0.55-0.75µM)]]\\ [[results:exp312|exp312 (0.55-1µM)]]\\ [[results:exp40|exp40 (200nM)]]|Endogenous estradiol metabolite, weak agonist for estrogen receptor, agonist of GPER1, microtubule destabilizer|**Class / Subclass 1: ** Metabolism / Metabolite\\ **Class / Subclass 2: ** Signal Transduction / GPCR Agonist\\ **Class / Subclass 3: ** Cell Cycle / Microtubule Poison|
|BI-2536|[[results:exp41|exp41 (1nM)]]\\ [[results:exp95|exp95 (4.2nM)]]\\ [[results:exp96|exp96 (20nM)]]|Inhibits PLK1 kinase, causes G2/M arrest|**Class / Subclass 1: ** Cell Cycle / Mitotic Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|BI-6727|[[results:exp42|exp42 (1nM)]]\\ [[results:exp97|exp97 (12.5nM)]]\\ [[results:exp98|exp98 (40nM)]]|Inhibits PLK1 kinase, causes G2/M arrest, improved version of BI-2536|**Class / Subclass 1: ** Cell Cycle / Mitotic Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|Docetaxel|[[results:exp159|exp159 (0.001-0.002µM)]]\\ [[results:exp45|exp45 (2nM)]]|Inihibts microtubule depolymerization, semi-synthetic analog of the paclitaxel|**Class / Subclass 1: ** Cell Cycle / Microtubule Poison\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor|
|HMS-I1|[[results:exp46|exp46 (1µM)]]\\ [[results:exp256|exp256 (10µM)]]|Inhibits HDAC|**Class / Subclass 1: ** Uncharacterized Mechanism / Chemical Screen Hit|
|Lapatinib|[[results:exp47|exp47 (5µM)]]|Inhibits EGFR and ErbB2 receptor tyrosine kinases|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|Mubritinib|[[results:exp48|exp48 (200nM)]]\\ [[results:exp65|exp65 (200nM)]]|Inhibits HER2 (Erb2) EGFR receptor tyrosine kinase|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|NFN1|[[results:exp49|exp49 (100nM)]]\\ [[results:exp99|exp99 (400nM)]]\\ [[results:exp100|exp100 (1µM)]]|Nitrofuran derivative, candidate ALDH2 inhibitor|**Class / Subclass 1: ** Infectious Disease / Antibiotic|
|Nicotinamide|[[results:exp50|exp50 (2000µM)]]\\ [[results:exp101|exp101 (1000µM)]]|NAD biosynthetic precursor, activates SIRT1|**Class / Subclass 1: ** Metabolism / Metabolite|
|Nifuroxazide|[[results:exp51|exp51 (1µM)]]\\ [[results:exp102|exp102 (5µM)]]|Nitrofuran antibiotic|**Class / Subclass 1: ** Infectious Disease / Antibiotic|
|Ribavirin|[[results:exp52|exp52 (10µM)]]\\ [[results:exp160|exp160 (10-15µM)]]|Prodrug metabolized to purine RNA nucleotide mimetic, also inhibits EIF4E|**Class / Subclass 1: ** Infectious Disease / Antiviral\\ **Class / Subclass 2: ** Metabolism / Antimetabolite\\ **Class / Subclass 3: ** DNA Damage, Repair and Replication / Reverse Transcriptase Inhibitor|
|Suberoylanilide-Hydroxamic-Acid|[[results:exp53|exp53 (20nM)]]|Inhibits class I, II, IV HDACs, chelates active site zinc ion|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|Paclitaxel|[[results:exp54|exp54 (2nM)]]\\ [[results:exp103|exp103 (4nM)]]|Inhibits microtubule depolymerisation, blocks metaphase to anaphase transition|**Class / Subclass 1: ** Cell Cycle / Microtubule Poison\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor|
|UM0131593|[[results:exp58|exp58 (100nM)]]\\ [[results:exp106|exp106 (200nM)]]|Unknown|**Class / Subclass 1: ** Uncharacterized Mechanism / Chemical Screen Hit|
|UMK57|[[results:exp59|exp59 (1µM)]]\\ [[results:exp107|exp107 (600nM)]]|Potentiates kinesin-13 (MCAK), destabilizes kinetochore-MT attachment, suppresses chromosome mis-segregation|**Class / Subclass 1: ** Cell Cycle / Mitotic Inhibitor\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor|
|Vinblastine|[[results:exp208|exp208 (15nM)]]\\ [[results:exp60|exp60 (2nM)]]\\ [[results:exp108|exp108 (200nM)]]|Inhibits microtubule polymerization and mitotic spindle formation, induces spindle assembly checkpoint (SAC)|**Class / Subclass 1: ** Cell Cycle / Microtubule Poison\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor|
|YM155|[[results:exp432|exp432 (1nM)]]\\ [[results:exp61|exp61 (0.2nM)]]|Inhibits expression of survivin, amongst other ascribed mechanisms|**Class / Subclass 1: ** Gene Regulation / Transcription Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Apoptosis Activator|
|BI-D1870|[[results:exp66|exp66 (3.15µM)]]\\ [[results:exp162|exp162 (2µM)]]|Inhibits ribosomal p90 S6 Kinase, active against RSK1/2/3/4 isoforms|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|BVD-523|[[results:exp67|exp67 (15µM)]]|Inhibits ERK1/2, ATP-competitive|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|Clomiphene|[[results:exp68|exp68 (4.4µM)]]|Nonsteroidal selective estrogen receptor modulator (SERM), mixed agonist and antagonist of ER|**Class / Subclass 1: ** Metabolism / Hormone Antagonist\\ **Class / Subclass 2: ** Gene Regulation / Nuclear Receptor Ligand|
|Deguelin|[[results:exp209|exp209 (150nM)]]\\ [[results:exp69|exp69 (50nM)]]|Derivative of rotenone, putative AKT inhibitor, complex I inhibitor|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor\\ **Class / Subclass 2: ** Organelle Function / Mitochondrial Inhibitor|
|INK128|[[results:exp70|exp70 (200nM)]]|Inhibits mTORC1 and mTORC2, ATP-competitive|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor\\ **Class / Subclass 2: ** Proteostasis / mTOR inhibitor|
|KU-0063794|[[results:exp71|exp71 (3.8µM)]]|ATP-competitive mTORC1 and mTORC2 inhibitor|**Class / Subclass 1: ** Proteostasis / mTOR inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|LB-100|[[results:exp72|exp72 (4.1µM)]]\\ [[results:exp210|exp210 (2µM)]]|Inhibits protein phosphatase 2A|**Class / Subclass 1: ** Signal Transduction / Phosphatase Inhibitor|
|LJH685|[[results:exp73|exp73 (5µM)]]\\ [[results:exp433|exp433 (50µM)]]|Inhibits p90 ribosomal S6 kinase (RSK)|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|MK-1775|[[results:exp75|exp75 (320nM)]]|Inhibits Wee1, alleviates CDK inhibition|**Class / Subclass 1: ** Cell Cycle / Kinase Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor\\ **Class / Subclass 3: ** DNA Damage, Repair and Replication / Checkpoint Signaling Inhibitor|
|Prochlorperazine|[[results:exp77|exp77 (5.2µM)]]|Antagonist of DRD2 receptors, used to treat nausea, schizophrenia, migraines, anxiety|**Class / Subclass 1: ** Signal Transduction / GPCR Antagonist|
|Pterostilbene|[[results:exp78|exp78 (16µM)]]|Putative sirtuin activator, anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic, anti-obesity, analog of resveratrol|**Class / Subclass 1: ** Gene Regulation / Epigenetic Activator|
|Q15|[[results:exp79|exp79 (2.7µM)]]\\ [[results:exp164|exp164 (1-2µM)]]|Putative condensin inhibitor|**Class / Subclass 1: ** Cell Cycle / Chromosome Dynamics Inhibitor|
|RO-3306|[[results:exp80|exp80 (4.7µM)]]\\ [[results:exp165|exp165 (3-4µM)]]|Inhibits CDK1, ATP-competitive, causes G2/M arrest|**Class / Subclass 1: ** Cell Cycle / Kinase Inhibitor|
|Selumetinib|[[results:exp81|exp81 (20µM)]]|Inhibits MEK1 and MEK2|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|Torin1|[[results:exp82|exp82 (80nM)]]|Inhibits mTORC1 and mTORC2, ATP competitive|**Class / Subclass 1: ** Proteostasis / mTOR inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|Trametinib|[[results:exp83|exp83 (10µM)]]|Inhibits MEK1 and MEK2, reversible allosteric mechanism, used in combination with BRAF V600E inhibitors|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|UM0125461|[[results:exp84|exp84 (740nM)]]|Unknown|**Class / Subclass 1: ** Uncharacterized Mechanism / Chemical Screen Hit|
|UM0129480|[[results:exp85|exp85 (7µM)]]|Unknown|**Class / Subclass 1: ** Uncharacterized Mechanism / Chemical Screen Hit|
|Vemurafenib|[[results:exp434|exp434 (6.6µM)]]\\ [[results:exp89|exp89 (6.6µM)]]|Inhibits BRAF-V300E, paradoxical RAF activation by stabilization of CRAF/BRAF heterodimer|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|WYE-354|[[results:exp90|exp90 (6µM)]]|Inhibits mTORC1 and mTORC2, ATP-competitive inhibitor|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor\\ **Class / Subclass 2: ** Proteostasis / mTOR inhibitor|
|(R)-DABN|[[results:exp93|exp93 (10µM + 10µM (S)-DABN)]]\\ [[results:exp111|exp111 (8µM)]]|Unknown, (R) atropisomer of 1,1'-Binaphthyl-2,2'-diamine|**Class / Subclass 1: ** Uncharacterized Mechanism / Chemical Screen Hit|
|(S)-DABN|[[results:exp93|exp93 (10µM + 10µM (R)-DABN)]]\\ [[results:exp112|exp112 (8µM)]]|Unknown, (S) atropisomer of 1,1'-Binaphthyl-2,2'-diamine|**Class / Subclass 1: ** Uncharacterized Mechanism / Chemical Screen Hit|
|1-Methylnicotinamide chloride|[[results:exp113|exp113 (1000µM)]]|Nicotinamde metabolite, generated by nicotinamide N-methyltransferase (NNMT)|**Class / Subclass 1: ** Metabolism / Metabolite|
|A-196|[[results:exp114|exp114 (10µM)]]|Inhibits SUV420H1 and SUV420H2 inhibitor, blocks di/trimethylation of H4K20me|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|A-366|[[results:exp115|exp115 (10µM)]]|Inhibits G9a/EHMT1, blocks methylation of H3K9|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|AICAR|[[results:exp116|exp116 (240µM)]]\\ [[results:exp211|exp211 (240µM)]]|Metabolic intermediate in purine biosynthesis, activates AMPK, has other putative targets|**Class / Subclass 1: ** Metabolism / Metabolite\\ **Class / Subclass 2: ** Signal Transduction / Kinase Activator|
|BH1|[[results:exp169|exp169 (1µM)]]|Unknown|**Class / Subclass 1: ** Uncharacterized Mechanism / Chemical Screen Hit|
|DMSO|[[results:exp120|exp120 (1%)]]|N/A|**Class / Subclass 1: ** Chemogenomic Negative Control / Solvent|
|Golgicide A|[[results:exp121|exp121 (2µM)]]\\ [[results:exp122|exp122 (4µM)]]|Inhibits cis-Golgi ArfGEF, blocks secretion at ER-Golgi|**Class / Subclass 1: ** Organelle Function / Vesicule Trafficking Inhibitor|
|GSK-LSD1|[[results:exp123|exp123 (10µM)]]|Inhibits LSD1 histone demethylase (H3K4me/me2, H3K9me)|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|GSK343|[[results:exp124|exp124 (3µM)]]|Inhibits EZH1 catalytic subunit of PRC2 histone methyltransferase (H3K27me3)|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|GSK461364A|[[results:exp125|exp125 (5nM)]]\\ [[results:exp126|exp126 (100nM)]]|Inhibits PLK1|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor\\ **Class / Subclass 2: ** Cell Cycle / Mitotic Inhibitor|
|GSK591|[[results:exp128|exp128 (2.6µM)]]|Inhibits protein arginine methyltransferase PRMT5, inactive control is SGC2096|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|Isonicotinamide|[[results:exp129|exp129 (500µM)]]|nicotinamide antagonist, putative SIRT1 activator|**Class / Subclass 1: ** Metabolism / Metabolite|
|JQ1|[[results:exp435|exp435 (800nM)]]\\ [[results:exp130|exp130 (10nM)]]|Inhibits BET bromodomain proteins BRD2, BRD3, BRD4, BRDT|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|L-741,742|[[results:exp131|exp131 (5µM)]]|DRD4 receptor antagonist|**Class / Subclass 1: ** Signal Transduction / GPCR antagonist|
|Metformin|[[results:exp132|exp132 (40µM)]]\\ [[results:exp170|exp170 (100-150µM)]]|Inhibits mitochondrial respiratory chain complex I, indirectly activates AMPK|**Class / Subclass 1: ** Organelle Function / Mitochondrial Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Activator|
|MKC9989|[[results:exp133|exp133 (10µM)]]|Inhibits IRE1, prevents ER unfolded protein response|**Class / Subclass 1: ** Proteostasis / Unfolded Protein Response Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|MS023|[[results:exp134|exp134 (2µM)]]\\ [[results:exp135|exp135 (7µM)]]|Inhibits protein arginine N-methyltransferase PRMT1|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|MS094|[[results:exp136|exp136 (2µM)]]|Inactive control for MS023 PRMT1 inhibitor|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|Nicotinamide Riboside|[[results:exp139|exp139 (100µM)]]|NAD precursor, activates SIRT1|**Class / Subclass 1: ** Metabolism / Metabolite|
|Nicotinate|[[results:exp140|exp140 (1000µM)]]|NAD precursor (a.k.a. niacin, vitamin B3)|**Class / Subclass 1: ** Metabolism / Metabolite|
|Nifurtimox|[[results:exp141|exp141 (1µM)]]|Nitrofuran derivative, forms nitro-anion radical metabolite, induces ROS|**Class / Subclass 1: ** Infectious Disease / Antitrypanosomal|
|OICR-9429|[[results:exp142|exp142 (10µM)]]|Inhibits interaction between WDR5 and MLL1 (KMT2A) in MLL H3K4 trimethylase complex|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|Phenformin|[[results:exp143|exp143 (20µM)]]\\ [[results:exp212|exp212 (20µM)]]|Inhibits mitochondrial respiratory chain complex I, indirectly activates AMPK|**Class / Subclass 1: ** Organelle Function / Mitochondrial Inhibitor\\ **Class / Subclass 2: ** Metabolism / Metabolic Enzyme Activator|
|PFI-3|[[results:exp144|exp144 (10µM)]]|Inhibits SMARCA2/4 and PB1 bromodomain proteins, components of SNF/SWI chromatin remodelling complex|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|PNU96415E|[[results:exp145|exp145 (10µM)]]|Antagonist of DRD4 and 5-HT2A receptors|**Class / Subclass 1: ** Signal Transduction / GPCR Antagonist|
|Quinacrine|[[results:exp146|exp146 (2.5µM)]]|Intercalates into DNA and RNA, interferes with transcription and translation|**Class / Subclass 1: ** Infectious Disease / Antimalarial\\ **Class / Subclass 2: ** DNA Damage, Repair and Replication / Intercalating Agent|
|Resveratrol|[[results:exp147|exp147 (16µM)]]|Putative sirtuin activator, many other ascribed activities, analog of pterostilbene|**Class / Subclass 1: ** Gene Regulation / Epigenetic Activator|
|SB202190|[[results:exp148|exp148 (10µM)]]|Inhibits p38‘± (MAPK14)and p38‘_ (MAPK11) kinase, ATP competitive|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|SB203580|[[results:exp149|exp149 (25µM)]]|p38 MAP kinase inhibitor|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor\\ **Class / Subclass 2: ** Proteostasis / Autophagy Inhibitor|
|SGC0649|[[results:exp150|exp150 (7µM)]]|Inactive control for SGC0649 (DOT1L methyltransferase inhibitor)|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|SGC0946|[[results:exp151|exp151 (7µM)]]|DOT1L methyltransferase inhibitor|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|SGC2043|[[results:exp152|exp152 (10µM)]]|Inactive control for A-196 (SUV420H1/H2 inhibitor)|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|SGC2096|[[results:exp153|exp153 (2.6µM)]]|Inactive control for GSK591 (PRMT5 inhibitor)|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|UNC1999|[[results:exp155|exp155 (2µM)]]|Inhibits EZH2 catalytic subunit of PRC2 histone methyltransferase (H3K27me3)|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|UNC2400|[[results:exp156|exp156 (2µM)]]|Inactive control for UNC1999 (EZH2 inhibitor)|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|2-Deoxy-D-glucose|[[results:exp214|exp214 (800µM)]]|Inhibits phosphoglucoisomerase, competitive, blocks glycolysis|**Class / Subclass 1: ** Metabolism / Metabolic Enzyme Inhibitor|
|3-Bromopyruvate|[[results:exp175|exp175 (7µM)]]|Inhibits hexokinase II, pyruvate analog, enzyme alkylator, blocks glycolysis|**Class / Subclass 1: ** Metabolism / Metabolic Enzyme Inhibitor|
|Apcin|[[results:exp177|exp177 (25µM + 2µM proTAME)]]\\ [[results:exp176|exp176 (50-100µM)]]|Inhibits substrate interactions with APC/C-Cdc20|**Class / Subclass 1: ** Proteostasis / E3 ubiquitin ligase inhibitor\\ **Class / Subclass 2: ** Cell Cycle / Mitotic Inhibitor|
|Colchicine|[[results:exp215|exp215 (9nM)]]|Inhibits microtubule polymerization|**Class / Subclass 1: ** Cell Cycle / Microtubule Poison\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor|
|Combretastatin A4|[[results:exp179|exp179 (0.002-0.003µM)]]|Inhibits microtubule polymerization|**Class / Subclass 1: ** Cell Cycle / Microtubule Poison\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor|
|Dynasore|[[results:exp436|exp436 (7µM)]]\\ [[results:exp180|exp180 (10µM)]]|Putative dynamin GTPase inhibitor, blocks endocytosis|**Class / Subclass 1: ** Organelle Function / Vesicule Trafficking Inhibitor|
|Erlotinib|[[results:exp216|exp216 (10µM)]]|Inhibits EGFR, also cyclin G-associated kinase (GAK)|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|IU1-47|[[results:exp182|exp182 (25µM)]]|Inhibits USP14, enhances protein degradation by 26S proteasome|**Class / Subclass 1: ** Proteostasis / Deubiquitinase (DUB) Inhibitor|
|IU1-C|[[results:exp183|exp183 (25µM)]]|Inactive analog of IU1-47|**Class / Subclass 1: ** Proteostasis / Ubiquitin-Proteasome Inhibitor|
|Ixabepilone|[[results:exp184|exp184 (0.004-0.005µM)]]|Inhibits microtubule depolymerization, semi-synthetic analog of epothilone|**Class / Subclass 1: ** Cell Cycle / Microtubule Poison\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor|
|L-BMAA|[[results:exp185|exp185 (500-750µM)]]|‘_-Methylamino-l-alanine, cyanobacterial neurotoxin, possible causative agent of ALS|**Class / Subclass 1: ** Environmental Stresses / Toxin|
|Mdivi-1|[[results:exp217|exp217 (15µM)]]|Inhibits GTPase dynamin-related protein 1 (Drp1), impairs mitochondrial fission, also inhibits respiratory complex I|**Class / Subclass 1: ** Organelle Function / Mitochondrial Inhibitor|
|proTAME|[[results:exp177|exp177 (2µM + 25µM Apcin)]]\\ [[results:exp187|exp187 (5µM)]]|Inhibits APC/C interaction with Cdc20/Cdh1 substrate recognition cofactors|**Class / Subclass 1: ** Proteostasis / E3 ubiquitin ligase inhibitor\\ **Class / Subclass 2: ** Cell Cycle / Mitotic Inhibitor|
|Temozolomide|[[results:exp189|exp189 (200µM)]]|Alkylates purine bases, prodrug hydrolyzes to 3-methyl-(triazen-1-yl)imidazole-4-carboxamide (MTIC)|**Class / Subclass 1: ** DNA Damage, Repair and Replication / Base Alkylation|
|Vincristine|[[results:exp190|exp190 (0.5nM)]]|Inhibits microtubule polymerization and mitotic spindle formation, induces spindle assembly checkpoint (SAC)|**Class / Subclass 1: ** Cell Cycle / Microtubule Poison\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor|
|A-395|[[results:exp218|exp218 (10µM)]]|Inhibits EED subunit of PRC2 complex, blocks H3K27me3|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|A-395N|[[results:exp219|exp219 (10µM)]]|Inactive analog of A-395 EED inhibitor|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|BAY-598|[[results:exp220|exp220 (4µM)]]|Inhibits SMYD2 lysine methyltransferase that acts on H3K4me, H3K36me, p53 and other substrates|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|Betulinic acid|[[results:exp222|exp222 (10-15µM)]]|Pentacyclic triterpenoid, claimed antiretroviral, antimalarial, anti-inflammatory, topoisomerase I/II inhibitor|**Class / Subclass 1: ** Infectious Disease / Antiviral\\ **Class / Subclass 2: ** DNA Damage, Repair and Replication / DNA Damaging Agent\\ **Class / Subclass 3: ** Uncharacterized Mechanism / Natural Product|
|Cabazitaxel|[[results:exp223|exp223 (1nM)]]|Microtubule stabilizer, semi-synthetic taxane|**Class / Subclass 1: ** Cell Cycle / Microtubule Poison\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor|
|CB-839|[[results:exp224|exp224 (10µM)]]|Inhibits glutaminase (GLS1), reversible|**Class / Subclass 1: ** Metabolism / Metabolic Enzyme Inhibitor|
|Celastrol|[[results:exp225|exp225 (120nM)]]|Putative antioxidant, anti-inflammatory, antiobesity anticancer, proteasome inhibitor|**Class / Subclass 1: ** Uncharacterized Mechanism / Natural Product\\ **Class / Subclass 2: ** Proteostasis / Ubiquitin-Proteasome Inhibitor|
|Cerivastatin|[[results:exp226|exp226 (150nM)]]|Inhibits HMG-CoA reductase, decreases cholesterol biogenesis, upregulates LDL receptors|**Class / Subclass 1: ** Metabolism / Metabolic Enzyme Inhibitor|
|Cryptotanshinone|[[results:exp227|exp227 (12µM)]]|Putative acetylcholinesterase and STAT3 inhibitor|**Class / Subclass 1: ** Uncharacterized Mechanism / Natural Product|
|Demecolcine|[[results:exp228|exp228 (30nM)]]|Inhibits microtubule polymerization, a.k.a. colcemid|**Class / Subclass 1: ** Cell Cycle / Microtubule Poison\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor|
|Dimethyloxaloylglycine|[[results:exp314|exp314 (11µM)]]\\ [[results:exp229|exp229 (100µM)]]\\ [[results:exp319|exp319 (11µM + 5µM ABT-702)]]|Prolylhydroxylase inhibitor, induces HIF-1α accumulation|**Class / Subclass 1: ** Metabolism / Metabolic Enzyme Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Other inhibitor|
|Epigallocatechin gallate|[[results:exp230|exp230 (20µM)]]|Polyphenol antioxidant from green tea, numerous claimed activities|**Class / Subclass 1: ** Metabolism / Nutraceutical\\ **Class / Subclass 2: ** Environmental Stresses / Food Additive|
|Epothilone B|[[results:exp231|exp231 (1.5nM)]]|Inhibits microtubule depolymerization, parent compound of ixabepilone|**Class / Subclass 1: ** Cell Cycle / Microtubule Poison\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor|
|Epothilone D|[[results:exp232|exp232 (4-6nM)]]|Microtubule stabilizer|**Class / Subclass 1: ** Organelle Function / Cytoskeletal Inhibitor\\ **Class / Subclass 2: ** Cell Cycle / Microtubule Poison|
|EPZ-5676|[[results:exp233|exp233 (30µM)]]|Inhibits DOT1L lysine methyltransferase (H3K79me2)|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|Ethanol|[[results:exp234|exp234 (1%)]]\\ [[results:exp437|exp437 (0.3%)]]|Pleiotropic effects on membranes, ion channels, enzymes, receptors|**Class / Subclass 1: ** Environmental Stresses / Solvent|
|Geldanamycin|[[results:exp235|exp235 (10nM)]]\\ [[results:exp316|exp316 (0.015-0.025µM)]]\\ [[results:exp317|exp317 (0.015-0.05µM)]]|HSP90 inhibitor|**Class / Subclass 1: ** Proteostasis / Chaperone Inhibitor|
|GSK2606414|[[results:exp236|exp236 (1µM)]]|Inhibits PERK, also KIT receptor|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|N,N-Diethyl-3-methylbenzamide|[[results:exp237|exp237 (100µM)]]\\ [[results:exp438|exp438 (500µM)]]|Insect repellent|**Class / Subclass 1: ** Environmental Stresses / Environmental Contaminant|
|Parthenolide|[[results:exp238|exp238 (2.5µM)]]|Sesquiterpene lactone with attributed activities in microtubule function, NF-κB activation, HDAC1 inhibition, MDM2 ubiquitination. Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew|**Class / Subclass 1: ** Cell Cycle / Microtubule Poison\\ **Class / Subclass 2: ** Uncharacterized Mechanism / Natural Product\\ **Class / Subclass 3: ** Signal Transduction / Apoptosis Inducer|
|PFI-2|[[results:exp239|exp239 (4µM)]]|Inhibits SETD7 lysine methyltransferase (H3K4me)|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|Pyridostatin|[[results:exp240|exp240 (4µM)]]|Binds and stabilizes telomeric and interstitial G-quadruplexes|**Class / Subclass 1: ** DNA Damage, Repair and Replication / G-Quadruplex Stabilizer|
|QNZ|[[results:exp439|exp439 (10nM)]]\\ [[results:exp241|exp241 (10nM)]]|Inhibits NF-κB activation, TNF-α production|**Class / Subclass 1: ** Gene Regulation / Transcription Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Apoptosis Inhibitor|
|Radicicol|[[results:exp242|exp242 (160nM)]]|Inhibits HSP90|**Class / Subclass 1: ** Proteostasis / Chaperone Inhibitor\\ **Class / Subclass 2: ** Infectious Disease / Antifungal|
|S-Trityl-L-cysteine|[[results:exp243|exp243 (500nM)]]|Inhibits Eg5 kinesin, blocks centrosome separation and bipolar spindle formation, arrests cells with monoastral spindles|**Class / Subclass 1: ** Organelle Function / Cytoskeletal Inhibitor\\ **Class / Subclass 2: ** Cell Cycle / Microtubule Poison|
|SB743921|[[results:exp244|exp244 (1nM)]]|Inhibits Eg5 kinesin, derivative of S-trityl-L-cysteine|**Class / Subclass 1: ** Cell Cycle / Mitotic Inhibitor|
|UM0011500|[[results:exp245|exp245 (5µM)]]\\ [[results:exp246|exp246 (10µM)]]|Unknown|**Class / Subclass 1: ** Uncharacterized Mechanism / Chemical Screen Hit|
|UM0130462|[[results:exp247|exp247 (0.025-0.035µM)]]|Unknown|**Class / Subclass 1: ** Uncharacterized Mechanism / Chemical Screen Hit|
|UM0131023|[[results:exp248|exp248 (50nM)]]|Unknown|**Class / Subclass 1: ** Uncharacterized Mechanism / Chemical Screen Hit|
|Vinorelbine|[[results:exp249|exp249 (1nM)]]|Inhibits microtubule polymerization and mitotic spindle formation, induces spindle assembly checkpoint (SAC)|**Class / Subclass 1: ** Cell Cycle / Microtubule Poison\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor|
|6-Thioguanine|[[results:exp259|exp259 (2µM)]]|Nucleoside analog, incorporated into telomeric DNA by telomerase, impairs proliferation of telomerase-positive cells|**Class / Subclass 1: ** Metabolism / Antimetabolite\\ **Class / Subclass 2: ** DNA Damage, Repair and Replication / Helix-Distorting Adduct|
|ABT-702|[[results:exp320|exp320 (5µM + 18µM CoCl2)]]\\ [[results:exp318|exp318 (5µM)]]\\ [[results:exp321|exp321 (5µM + 11µM Deferoxamine)]]\\ [[results:exp319|exp319 (5µM + 11µM Dimethyloxaloylglycine)]]\\ [[results:exp260|exp260 (100nM)]]\\ [[results:exp261|exp261 (5µM)]]|Inhibits adenosine kinase (ADK)|**Class / Subclass 1: ** Metabolism / Metabolic Enzyme Inhibitor|
|ALDA-1|[[results:exp262|exp262 (10µM)]]|Activates mitochondrial aldehyde dehydrogenase (ALDH2), may attenuate ethanol addiction|**Class / Subclass 1: ** Metabolism / Metabolic Enzyme Activator|
|Aphidicolin|[[results:exp440|exp440 (400nM)]]\\ [[results:exp263|exp263 (40nM)]]|Inhibits DNA polymerases Polα, Polδ, Polϵ and Polζ|**Class / Subclass 1: ** DNA Damage, Repair and Replication / Replication Inhibitor\\ **Class / Subclass 2: ** Cell Cycle / Replication Inhibitor\\ **Class / Subclass 3: ** Infectious Disease / Antiviral|
|Arsenate|[[results:exp264|exp264 (40µM)]]|Heavy metal toxin, environmental contaminant|**Class / Subclass 1: ** Environmental Stresses / Heavy Metal|
|Bisphenol A|[[results:exp269|exp269 (100µM)]]|Widely-used in plastics and epoxy resins, endocrine disrupter|**Class / Subclass 1: ** Environmental Stresses / Industrial Chemical|
|Camptothecin|[[results:exp270|exp270 (1nM)]]|Inhibits topoisomerase I, stabilizes TopoI-DNA complex, causes DNA strand breaks|**Class / Subclass 1: ** DNA Damage, Repair and Replication / Clastogen|
|CCT251545|[[results:exp271|exp271 (200nM)]]\\ [[results:exp326|exp326 (20µM)]]|Inhibits CDK8 and CDK19 mediator-associated kinases|**Class / Subclass 1: ** Gene Regulation / Transcription Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|CHIR-124|[[results:exp272|exp272 (40nM)]]|Inhibits CHK1, blocks checkpoint arrest, potentiates DNA damaging agents|**Class / Subclass 1: ** DNA Damage, Repair and Replication / Checkpoint Signaling Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|Cisplatin|[[results:exp273|exp273 (350nM)]]|Intrastrand cross-linker|**Class / Subclass 1: ** DNA Damage, Repair and Replication / Inter/Intra-strand Crosslinker|
|Citral|[[results:exp274|exp274 (50µM)]]\\ [[results:exp275|exp275 (75µM)]]|putative ALDH inhibitor, essential oil|**Class / Subclass 1: ** Uncharacterized Mechanism / Natural Product\\ **Class / Subclass 2: ** Metabolism / Metabolic Enzyme Inhibitor|
|Curcumin|[[results:exp277|exp277 (6.5µM)]]|Component of tumeric spice, many claimed activities but viewed as pan-assay interference compound|**Class / Subclass 1: ** Uncharacterized Mechanism / Natural Product\\ **Class / Subclass 2: ** Metabolism / Nutraceutical|
|CVT-10216|[[results:exp278|exp278 (100nM)]]|Inhibits mitochondrial aldehyde dehydrogenase (ALDH2), main enzyme for oxidative alcohol metabolism|**Class / Subclass 1: ** Metabolism / Metabolic Enzyme Inhibitor|
|D-Fructose|[[results:exp279|exp279 (10000µM)]]|Monosaccharide|**Class / Subclass 1: ** Metabolism / Nutrient|
|Daidzin|[[results:exp280|exp280 (10µM)]]|Isoflavone from soy bean, putative ALDH inhibitor|**Class / Subclass 1: ** Uncharacterized Mechanism / Natural Product\\ **Class / Subclass 2: ** Metabolism / Metabolic Enzyme Inhibitor|
|Disulfiram|[[results:exp281|exp281 (4.3µM)]]|ALDH1 inhibitor, putative 26S proteasome inhibitor|**Class / Subclass 1: ** Metabolism / Metabolic Enzyme Inhibitor\\ **Class / Subclass 2: ** Proteostasis / Ubiquitin-Proteasome Inhibitor|
|Fluvastatin|[[results:exp282|exp282 (2.2µM)]]|Inhibits HMG-CoA reductase, decreases cholesterol biogenesis, upregulates LDL-receptors|**Class / Subclass 1: ** Metabolism / Metabolic Enzyme Inhibitor|
|Glyphosate|[[results:exp283|exp283 (1000µM)]]|Inhibits 5-enolpyruvylshikimate-3-phosphate synthase, a.k.a Roundup|**Class / Subclass 1: ** Environmental Stresses / Herbicide|
|GW501516|[[results:exp285|exp285 (25µM)]]|PPARδ receptor agonist, increases metabolism, banned performance enhancer|**Class / Subclass 1: ** Gene Regulation / Nuclear Receptor Ligand\\ **Class / Subclass 2: ** Metabolism / Hormone Agonist|
|HMS-I2|[[results:exp286|exp286 (1µM)]]\\ [[results:exp287|exp287 (5µM)]]\\ [[results:exp288|exp288 (10µM)]]|putative HDAC inhibitor from cell-based screen|**Class / Subclass 1: ** Uncharacterized Mechanism / Chemical Screen Hit|
|Hydroxyurea|[[results:exp329|exp329 (100µM)]]\\ [[results:exp289|exp289 (15µM)]]|Inhibits ribonucleotide reductase, scavenges tyrosyl radicals|**Class / Subclass 1: ** Metabolism / Metabolic Enzyme Inhibitor\\ **Class / Subclass 2: ** DNA Damage, Repair and Replication / Replication Inhibitor|
|LLY-283|[[results:exp290|exp290 (2.6µM)]]|Inhibits protein arginine methyltransferase PRMT5, inactive control is LLY-284|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|LLY-284|[[results:exp291|exp291 (2.6µM)]]|Inactive control for LLY-283 PRMT5 inhibitor|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|Menadione|[[results:exp292|exp292 (5µM)]]|Synthetic analog of vitamin K, quinone redox cycle generates ROS|**Class / Subclass 1: ** Metabolism / Nutrient\\ **Class / Subclass 2: ** Environmental Stresses / Food Additive|
|Myriocin|[[results:exp293|exp293 (25µM)]]|Inhibits serine palmitoyltransferase (SPT1), sphingolipid biosynthesis|**Class / Subclass 1: ** Infectious Disease / Antibiotic\\ **Class / Subclass 2: ** Metabolism / Metabolic Enzyme Inhibitor|
|Nutlin-3A|[[results:exp294|exp294 (1.6µM)]]|Inhibits p53-MDM2 interaction|**Class / Subclass 1: ** Proteostasis / E3 ubiquitin ligase inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Apoptosis Activator|
|Pyronaridine|[[results:exp295|exp295 (1µM)]]|Prevents sequestration of heme into hemozoin, forms toxic complex with heme, enhances hematin-induced red blood cell lysis, also intercalates into DNA|**Class / Subclass 1: ** Infectious Disease / Antimalarial\\ **Class / Subclass 2: ** DNA Damage, Repair and Replication / Intercalating Agent|
|Sucrose|[[results:exp298|exp298 (20000µM)]]|Disaccharide composed of glucose and fructose|**Class / Subclass 1: ** Metabolism / Nutrient|
|Talazoparib|[[results:exp299|exp299 (6nM)]]|Inhibits PARP1 and PARP2, blocks ssDNA break repair, selectively toxic to BRCA1/2 negative cancers|**Class / Subclass 1: ** DNA Damage, Repair and Replication / PARP Inhibitor|
|VE-822|[[results:exp300|exp300 (40nM)]]|Inhibits ATR|**Class / Subclass 1: ** DNA Damage, Repair and Replication / Checkpoint Signaling Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|VER-155008|[[results:exp301|exp301 (3.9µM)]]|Inhibits HSP70|**Class / Subclass 1: ** Proteostasis / Chaperone Inhibitor|
|5-Azacytidine|[[results:exp330|exp330 (2µM)]]|Analog of cytidine ribonucleoside, DNA methyltransferase inhibitor|**Class / Subclass 1: ** Metabolism / Antimetabolite\\ **Class / Subclass 2: ** Gene Regulation / Epigenetic Inhibitor\\ **Class / Subclass 3: ** DNA Damage, Repair and Replication / Replication Inhibitor|
|A-769662|[[results:exp331|exp331 (20µM)]]|Activates AMP-activated protein kinase (AMPK), allosteric|**Class / Subclass 1: ** Signal Transduction / Kinase Activator|
|Adefovir|[[results:exp332|exp332 (20µM)]]|Nucleoside reverse transcriptase inhibitor (NRTI), active against HBV and HSV|**Class / Subclass 1: ** Infectious Disease / Antiviral\\ **Class / Subclass 2: ** DNA Damage, Repair and Replication / Reverse Transcriptase Inhibitor\\ **Class / Subclass 3: ** Metabolism / Antimetabolite|
|Tretinoin|[[results:exp333|exp333 (8µM)]]\\ [[results:exp334|exp334 (40µM)]]|Ligand for retinoic acid receptor (RAR) and retinoid X receptor (RXR), metabolite of vitamin A1|**Class / Subclass 1: ** Gene Regulation / Nuclear Receptor Ligand\\ **Class / Subclass 2: ** Metabolism / Metabolite|
|Aminopterin|[[results:exp335|exp335 (5nM)]]|Inhibits dihydrofolate reductase (DHFR)|**Class / Subclass 1: ** Metabolism / Antimetabolite\\ **Class / Subclass 2: ** DNA Damage, Repair and Replication / Replication Inhibitor|
|Asunaprevir|[[results:exp336|exp336 (3µM)]]|Block the enzymatic activity of the HCV NS3 protease|**Class / Subclass 1: ** Infectious Disease / Antiviral\\ **Class / Subclass 2: ** Proteostasis / Protease Inhibitor|
|BN82002|[[results:exp340|exp340 (4µM)]]|Inhibits CDC25 phosphatases, active against CDC25A/B/C isoforms|**Class / Subclass 1: ** Cell Cycle / Phosphatase inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Phosphatase Inhibitor|
|BIC1|[[results:exp341|exp341 (20µM)]]|Inhibits BRD2, blocks recognition of acetylated H4K12|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|A23187|[[results:exp342|exp342 (400nM)]]|Calcium ionophore|**Class / Subclass 1: ** Infectious Disease / Antibiotic\\ **Class / Subclass 2: ** Organelle Function / Membrane Ionophore|
|Centrinone|[[results:exp343|exp343 (500nM)]]|Inhibits PLK4, blocks centriole duplication, causes p53-dependent G1 arrest|**Class / Subclass 1: ** Cell Cycle / Mitotic Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|Chlorpromazine|[[results:exp344|exp344 (10µM)]]|Antipsychotic, pleiotropic antagonist for dopamine, seratonin, histamine, adrenergic, muscarinic receptors, potassium and sodium channels, also disrupts clathrin-mediated endocytosis|**Class / Subclass 1: ** Signal Transduction / GPCR Antagonist\\ **Class / Subclass 2: ** Signal Transduction / Ion Channel Inhibitor\\ **Class / Subclass 3: ** Organelle Function / Vesicule Trafficking Inhibitor|
|Cidofovir|[[results:exp345|exp345 (10µM)]]|Acyclic nucleoside phosphonate, inhibits DNA polymerase|**Class / Subclass 1: ** Infectious Disease / Antiviral\\ **Class / Subclass 2: ** Metabolism / Antimetabolite\\ **Class / Subclass 3: ** DNA Damage, Repair and Replication / Replication Inhibitor|
|CoCl2|[[results:exp320|exp320 (18µM + 5µM ABT-702)]]\\ [[results:exp346|exp346 (18µM)]]|Hypoxia mimetic, inhibits VHL-HIF-1α interaction, induces HIF-1α accumulation|**Class / Subclass 1: ** Environmental Stresses / Heavy Metal|
|Cyclosporin A|[[results:exp307|exp307 (3µM + 2µM Rapamycin)]]\\ [[results:exp347|exp347 (800nM)]]\\ [[results:exp348|exp348 (3µM)]]|Inhibits calcineurin, forms ternary complex with immunophilin (FBKP) and calcineurin|**Class / Subclass 1: ** Signal Transduction / Phosphatase Inhibitor\\ **Class / Subclass 2: ** Proteostasis / mTOR inhibitor|
|Cytochalasin B|[[results:exp349|exp349 (5µM)]]|Binds fast-growing (barbed) end of F-actin filament, inhibits actin polymerization|**Class / Subclass 1: ** Cell Cycle / Cytokinesis Inhibitor\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor\\ **Class / Subclass 3: ** Environmental Stresses / Toxin|
|Deferoxamine|[[results:exp321|exp321 (11µM + 5µM ABT-702)]]\\ [[results:exp350|exp350 (11µM)]]|Iron chelator, hypoxia mimetic, induces HIF-1‘± accumulation|**Class / Subclass 1: ** Environmental Stresses / Metal Chelator|
|Dexamethasone|[[results:exp351|exp351 (6nM)]]\\ [[results:exp352|exp352 (0.006-0.015µM)]]|Glucocorticoid receptor agonist, anti-inflammatory|**Class / Subclass 1: ** Metabolism / Hormone Agonist\\ **Class / Subclass 2: ** Signal Transduction / GPCR Agonist|
|Diepoxybutane|[[results:exp354|exp354 (3µM)]]|DNA crosslinker, carcinogen|**Class / Subclass 1: ** DNA Damage, Repair and Replication / Inter/Intra-strand Crosslinker|
|Dinaciclib|[[results:exp355|exp355 (7nM)]]|Inhibits CDK2, CDK5, CDK1, CDK9|**Class / Subclass 1: ** Cell Cycle / Cell Cycle Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor\\ **Class / Subclass 3: ** Gene Regulation / Transcription Inhibitor|
|Docosahexaenoic acid|[[results:exp356|exp356 (50µM)]]|Essential omega-3 fatty acid|**Class / Subclass 1: ** Metabolism / Metabolite|
|Dorsomorphin|[[results:exp357|exp357 (5µM)]]|Putative inhibitor of AMPK and BMP signalling|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|FK-506|[[results:exp308|exp308 (5µM + 2µM Rapamycin)]]\\ [[results:exp358|exp358 (5µM)]]\\ [[results:exp359|exp359 (30µM)]]|Inhibits calcineurin|**Class / Subclass 1: ** Signal Transduction / Phosphatase Inhibitor\\ **Class / Subclass 2: ** Proteostasis / mTOR inhibitor|
|Genistein|[[results:exp360|exp360 (15µM)]]|Inhibits tyrosine kinases, phytoestrogen, toposiomerase II, pleiotropic effects|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor\\ **Class / Subclass 2: ** Metabolism / Hormone Agonist\\ **Class / Subclass 3: ** Gene Regulation / Nuclear Receptor Ligand|
|GSK-J4|[[results:exp362|exp362 (1µM)]]\\ [[results:exp363|exp363 (1-1.25µM)]]\\ [[results:exp441|exp441 (1.5µM)]]|JMJD3/KDM6B, UTX/KDM6A histone demethylase inhibitor (H3K27me2/me3)|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|I-BRD9|[[results:exp365|exp365 (4µM)]]|Inhibits BRD9 subunit of SWI/SNF complex|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|Ibrutinib|[[results:exp372|exp372 (1µM)]]\\ [[results:exp442|exp442 (10µM)]]|Inhibits BTK|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|Latrunculin B|[[results:exp374|exp374 (10µM)]]|Binds actin monomers, inhibits actin polymerization|**Class / Subclass 1: ** Cell Cycle / Cytokinesis Inhibitor\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor\\ **Class / Subclass 3: ** Environmental Stresses / Toxin|
|Lenalidomide|[[results:exp375|exp375 (20µM)]]|IMiD that targets IKZF1/3 for ubiquitination by CUL4-cereblon complex|**Class / Subclass 1: ** Proteostasis / Bivalent Ligand|
|Losmapimod|[[results:exp376|exp376 (1µM)]]|Inhibits p38‘±/‘_ MAP kinases|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|MSC2530818|[[results:exp379|exp379 (10µM)]]|Inhibits CDK8|**Class / Subclass 1: ** Gene Regulation / Transcription Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|NMS-873|[[results:exp380|exp380 (70nM)]]|Inhibits p97 AAA-ATPase|**Class / Subclass 1: ** Proteostasis / Ubiquitin-Proteasome Inhibitor|
|Palbociclib|[[results:exp382|exp382 (1µM)]]|Inhibits CDK4 and CDK6, causes G1 arrest|**Class / Subclass 1: ** Cell Cycle / Cyclin Dependent Kinase Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|PF-06409577|[[results:exp389|exp389 (20µM)]]|Activates AMPK, lowers cholesterol levels in NAFLD/NASH preclinical models|**Class / Subclass 1: ** Signal Transduction / Kinase Activator|
|Pifithrin-α|[[results:exp390|exp390 (20µM)]]|Claimed to inhibit p53 but has p53-independent effects, cyclic form may increase stem cell reprogramming|**Class / Subclass 1: ** Signal Transduction / Apoptosis Inhibitor|
|Pomalidomide|[[results:exp391|exp391 (20µM)]]|IMiD that targets neo-substrates IKZF1/3 for ubiquitination by CUL4A-DDB1-cereblon complex|**Class / Subclass 1: ** Proteostasis / Ubiquitin-Proteasome Activator|
|PT 1|[[results:exp392|exp392 (25µM)]]|Activates AMPK, selectivefor ‘_1-complexes, may antagonize autoinhibition|**Class / Subclass 1: ** Signal Transduction / Kinase Activator|
|Resminostat|[[results:exp393|exp393 (500nM)]]|Inhibits HDAC 1, HDAC3, HDAC6|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|Salubrinal|[[results:exp399|exp399 (20µM)]]|Inhibits eIF2‘± phosphatase, indirectly inhibits eIF2‘±|**Class / Subclass 1: ** Proteostasis / Translation Inhibitor|
|Senexin A|[[results:exp400|exp400 (25µM)]]|Inhibits CDK8, suppresses induction of gene expression|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor\\ **Class / Subclass 2: ** Gene Regulation / Transcription Inhibitor|
|SNS-032|[[results:exp401|exp401 (25µM)]]\\ [[results:exp443|exp443 (15µM)]]|Inhibits CDK2, CDK7, CDK9|**Class / Subclass 1: ** Cell Cycle / Cyclin Dependent Kinase Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|Tenofovir|[[results:exp405|exp405 (10µM)]]|Nucleoside reverse transcriptase inhibitor, chain terminator|**Class / Subclass 1: ** Infectious Disease / Antiviral|
|Thalidomide|[[results:exp406|exp406 (20µM)]]|IMiD that targets neo-substrates IKZF1/3 for ubiquitination by CUL4A-DDB1-cereblon complex|**Class / Subclass 1: ** Proteostasis / Bivalent Ligand|
|Thapsigargin|[[results:exp407|exp407 (5nM)]]|Inhibits sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), non-competitive inhibitor, raises intracellular calcium concentration|**Class / Subclass 1: ** Organelle Function / Membrane Transport Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Ion Channel Inhibitor|
|THZ531|[[results:exp409|exp409 (110nM)]]\\ [[results:exp410|exp410 (0.11-0.125µM)]]\\ [[results:exp412|exp412 (0.11-0.35µM)]]\\ [[results:exp413|exp413 (0.11-0.175µM)]]\\ [[results:exp444|exp444 (225nM)]]|Inhibits CDK12 and CDK13, forms covalent adduct, more selective analog of THZ1, blocks phosphorylation of the C-terminal domain of RNA polymerase II|**Class / Subclass 1: ** Gene Regulation / Transcription Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|Tozasertib|[[results:exp414|exp414 (100nM)]]|Inhibits Aurora A,B,C kinases, blocks cytokinesis, also inhibits RIPK1 and blocks necroptosis|**Class / Subclass 1: ** Cell Cycle / Cytokinesis Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|Trichostatin A|[[results:exp415|exp415 (60nM)]]|Inhibits class I and II HDAC enzymes|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor\\ **Class / Subclass 2: ** Infectious Disease / Antifungal|
|Tubacin|[[results:exp416|exp416 (1.6µM)]]|Inhibits HDAC6 selectively|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|Tubastatin A|[[results:exp417|exp417 (2.5µM)]]|Inhibits HDAC6 selectively|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|Tunicamycin|[[results:exp418|exp418 (40nM)]]\\ [[results:exp419|exp419 (0.04-0.075µM)]]\\ [[results:exp420|exp420 (0.04-0.125µM)]]|Inhibits GlcNAc phosphotransferase (GPT), blocks N-linked glycoslylation, induces protein unfolding in ER, nucleoside antibiotic|**Class / Subclass 1: ** Proteostasis / Unfolded Protein Response Activator\\ **Class / Subclass 2: ** Infectious Disease / Antibiotic|
|VHL Ligand 1|[[results:exp421|exp421 (20µM)]]|Binds VHL, targeting moiety for PROTACs|**Class / Subclass 1: ** Proteostasis / Bivalent Ligand|
|Wiskostatin|[[results:exp422|exp422 (3µM)]]|Inhibits N-WASP, blocks actin polymerization|**Class / Subclass 1: ** Organelle Function / Cytoskeletal Inhibitor\\ **Class / Subclass 2: ** Cell Cycle / Actin Inhibitor|
|Zebularine|[[results:exp423|exp423 (20µM)]]|Inhibits cytidine deaminase, transition state analog, also inhibits DNMT1 via reversible covalent complex|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|β-Estradiol|[[results:exp425|exp425 (550nM)]]|Agonist for estrogen receptor (ER), inactive control for 2-Methoxyestradiol|**Class / Subclass 1: ** Gene Regulation / Transcription Activator\\ **Class / Subclass 2: ** Metabolism / Hormone Agonist|
|∆9-Tetrahydrocannabinol|[[results:exp445|exp445 (30µM)]]|Agonist of CB1 and CB2 cannabinoid receptors|**Class / Subclass 1: ** Environmental Stresses / Controlled Substance\\ **Class / Subclass 2: ** Signal Transduction / GPCR Agonist|
|4-Nitroquinoline N-oxide|[[results:exp446|exp446 (500nM)]]|UV mimetic, metabolized to electrohpile that forms stable quinolone monoadducts|**Class / Subclass 1: ** DNA Damage, Repair and Replication / Helix-Distorting Adduct|
|Amiloride|[[results:exp447|exp447 (100µM)]]|Inhibits epithelial sodium channel (ENaC) and other Na+/H+ channels, also inhibits urokinase-type plasminogen activator (uPA)|**Class / Subclass 1: ** Signal Transduction / Ion Channel Inhibitor|
|Ammonium tetrathiomolybdate|[[results:exp448|exp448 (10µM)]]|Inhibits cuproenzymes superoxide dismutase 1 (SOD1) and cytochrome c oxidase (COX)|**Class / Subclass 1: ** Environmental Stresses / Metal Chelator\\ **Class / Subclass 2: ** Metabolism / Metabolic Enzyme Inhibitor|
|Arsenic trioxide|[[results:exp449|exp449 (60µM)]]|Induces degradation of aberrant PML-RAR‘± fusion protein in acute promyelocytic leukemia|**Class / Subclass 1: ** Environmental Stresses / Heavy Metal\\ **Class / Subclass 2: ** Signal Transduction / Apoptosis Inducer|
|Artemisinin|[[results:exp450|exp450 (50µM)]]|Sesquiterpene endoperoxide activated by heme, kills malaria parasite through oxidative damage|**Class / Subclass 1: ** Infectious Disease / Antimalarial|
|Atovaquone|[[results:exp451|exp451 (15µM)]]|Ubiquinone analog, inhibits mitochondrial complex III, induces DNA strand breaks|**Class / Subclass 1: ** Infectious Disease / Antimalarial\\ **Class / Subclass 2: ** Organelle Function / Mitochondrial Inhibitor\\ **Class / Subclass 3: ** DNA Damage, Repair and Replication / DNA Damaging Agent|
|Azithromycin|[[results:exp452|exp452 (100µM)]]|Binds 50S subunit of bacterial ribosome, inhibits translation|**Class / Subclass 1: ** Infectious Disease / Antibiotic\\ **Class / Subclass 2: ** Proteostasis / Translation Inhibitor|
|B02|[[results:exp453|exp453 (10µM)]]|Inhibits RAD51 recombinase, blocks homologous recombination|**Class / Subclass 1: ** DNA Damage, Repair and Replication / Repair Protein Inhibitor|
|Bafilomycin A1|[[results:exp454|exp454 (9nM)]]|Inhibits vacuolar-type H+ ATPase, blocks acidification of lysosome|**Class / Subclass 1: ** Signal Transduction / Ion Channel Inhibitor\\ **Class / Subclass 2: ** Organelle Function / Membrane Transport Inhibitor\\ **Class / Subclass 3: ** Proteostasis / Autophagy Inhibitor|
|Benzoate|[[results:exp455|exp455 (10000µM)]]\\ [[results:exp456|exp456 (20000µM)]]|Food additive (E211), bacteriostatic and fungistatic|**Class / Subclass 1: ** Environmental Stresses / Food Preservative|
|Bisphenol F|[[results:exp457|exp457 (50µM)]]|BPA analog and substitute, endocrine disrupter|**Class / Subclass 1: ** Environmental Stresses / Industrial Chemical|
|Bisphenol S|[[results:exp458|exp458 (100µM)]]|BPA analog and substitute in BPA-free plastics, endocrine disrupter|**Class / Subclass 1: ** Environmental Stresses / Industrial Chemical|
|Bleomycin|[[results:exp459|exp459 (5µM)]]|Induces DNA strand breaks, possibly by iron chelation and ROS generation, or generation of alkali-labile lesions|**Class / Subclass 1: ** DNA Damage, Repair and Replication / Clastogen|
|BML-284|[[results:exp460|exp460 (90nM)]]|Wnt agonist, GSK3-‘_ dependent, activates ‘_-catenin/TCF-dependent transcription|**Class / Subclass 1: ** Signal Transduction / GPCR Agonist\\ **Class / Subclass 2: ** Gene Regulation / Transcription Activator|
|BS-181|[[results:exp461|exp461 (20µM)]]|Inhibits CDK7, causes G1 arrest and apoptosis|**Class / Subclass 1: ** Gene Regulation / Transcription Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|Cadmium|[[results:exp462|exp462 (60µM)]]|Widely used metal in manufacturing and pigments, known carcinogen|**Class / Subclass 1: ** Environmental Stresses / Heavy Metal|
|Caffeine|[[results:exp463|exp463 (2600µM)]]|CNS stimulant, antagonist of adenosine receptors, inhibits phosphodiesterases, modulates intracellular calcium|**Class / Subclass 1: ** Signal Transduction / GPCR Antagonist\\ **Class / Subclass 2: ** Environmental Stresses / Food Additive|
|Calcipotriol|[[results:exp464|exp464 (5µM)]]|Synthetic vitamin D3 analog, binds vitamin D nuclear hormone receptor|**Class / Subclass 1: ** Metabolism / Vitamin\\ **Class / Subclass 2: ** Signal Transduction / Nuclear Receptor Ligand|
|Cannabidiol|[[results:exp465|exp465 (13µM)]]\\ [[results:exp466|exp466 (20µM)]]|Negative allosteric modulator of cannabinoid CB1 receptor|**Class / Subclass 1: ** Environmental Stresses / Psychoactive Drug\\ **Class / Subclass 2: ** Signal Transduction / GPCR Antagonist|
|CAY10603|[[results:exp467|exp467 (550nM)]]|Inhibits HDAC6, selective over other HDACs|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|CB-5083|[[results:exp468|exp468 (400nM)]]|Inhibits p97 AAA-ATPase|**Class / Subclass 1: ** Proteostasis / Unfoldase Inhibitor|
|CFI-400945|[[results:exp469|exp469 (25µM)]]|Inhibits PLK4, blocks centriole duplication, induces mitotic defects and cell death|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor\\ **Class / Subclass 2: ** Cell Cycle / Mitotic Inhibitor|
|Chloroquine|[[results:exp470|exp470 (32µM)]]|Lysosomotropic agent, prevents sequestration of heme into hemozoin, forms toxic complex with heme, enhances hematin-induced red blood cell lysis, also intercalates into DNA|**Class / Subclass 1: ** Infectious Disease / Antimalarial\\ **Class / Subclass 2: ** DNA Damage, Repair and Replication / Intercalating Agent\\ **Class / Subclass 3: ** Proteostasis / Autophagy Inhibitor|
|Cholesterol|[[results:exp471|exp471 (3-100nM)]]|Major membrane lipid, precursor for the biosynthesis of steroid hormones, bile acids, and vitamin D|**Class / Subclass 1: ** Metabolism / Metabolite|
|CI-1040|[[results:exp472|exp472 (9.5µM)]]|Inhibits MEK1, blocks ERK1/2 activation|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|Cincreasin|[[results:exp473|exp473 (100µM)]]|Inhibits budding yeast Mps1 but not human MPS1 (TTK), overrides spindle checkpoint|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor\\ **Class / Subclass 3: ** Cell Cycle / Actin Inhibitor|
|CR-1-31-b|[[results:exp474|exp474 (5nM)]]|Inhibits EIF4A, blocks translation by trapping EIF4A on mRNA at poly-purine sites|**Class / Subclass 1: ** Proteostasis / Translation Inhibitor|
|Cyclic AMP|[[results:exp475|exp475 (200µM)]]|Second messenger, activates PKA, ion channels, cyclic nucleotide-binding proteins|**Class / Subclass 1: ** Metabolism / Metabolite\\ **Class / Subclass 2: ** Signal Transduction / Kinase Activator|
|Dihydrosphingosine|[[results:exp476|exp476 (8µM)]]|Inhibits cytosolic phospholipase A2α (cPLA2α) activity|**Class / Subclass 1: ** Metabolism / Metabolite|
|DKK1|[[results:exp477|exp477 (89ng/mL)]]|Dickkopf1 (DKK1), recombinant protein inhibitor of WNT signaling, binds LRP5/LRP6 co-receptor and KRM1|**Class / Subclass 1: ** Signal Transduction / GPCR Antagonist|
|Doxorubicin|[[results:exp478|exp478 (20nM)]]|DNA intercalator, traps topoisomerase II complex|**Class / Subclass 1: ** DNA Damage, Repair and Replication / Topoisomerase II Inhibitor\\ **Class / Subclass 2: ** Infectious Disease / Antibiotic|
|ETC-159|[[results:exp480|exp480 (50µM)]]|Inhibits PORCN palmitoyl transferase that modifies WNT ligands|**Class / Subclass 1: ** Signal Transduction / Other Inhibitor|
|Ethambutol|[[results:exp481|exp481 (25µM)]]|Inhibits arabinosyl transferase, interferes with cell wall formation|**Class / Subclass 1: ** Infectious Disease / Antibiotic|
|Fas-L|[[results:exp482|exp482 (44ng/mL)]]|Ligand for Fas receptor, triggers apoptosis|**Class / Subclass 1: ** Signal Transduction / Other Receptor Agonist|
|FTY720|[[results:exp483|exp483 (3µM)]]|Agonist of sphingosine 1-phosphate receptor-1 (S1P1), derived from myriocin|**Class / Subclass 1: ** Metabolism / Metabolic Enzyme Inhibitor|
|GSK-J5|[[results:exp484|exp484 (1.5µM)]]|Inactive isomer of GSKJ4|**Class / Subclass 1: ** Gene Regulation / Epigenetic Inhibitor|
|GSK 626616|[[results:exp485|exp485 (14µM)]]|Inhibits DYRK3, prevents stress granule dissolution, mTORC1 release|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|Heregulin B|[[results:exp486|exp486 (44ng/mL)]]|EGF family ligand for ErbB receptors, a.k.a. neuregulin-1|**Class / Subclass 1: ** Signal Transduction / Receptor Ligand|
|Hinokiflavone|[[results:exp487|exp487 (12µM)]]|Putative splicing inhibitor, ROS generation|**Class / Subclass 1: ** Uncharacterized Mechanism / Natural Product\\ **Class / Subclass 2: ** Gene Regulation / Splicing Inhibitor|
|Hippuristanol|[[results:exp488|exp488 (120nM)]]\\ [[results:exp489|exp489 (120nM)]]|Inhibits translation by trapping EIF4A on mRNA at poly-purine sites|**Class / Subclass 1: ** Proteostasis / Translation Inhibitor|
|Hydroxychloroquine|[[results:exp490|exp490 (30µM)]]|Lysosomotropic agent, prevents sequestration of heme into hemozoin, forms toxic complex with heme, also inhibits TLR 7/9|**Class / Subclass 1: ** Infectious Disease / Antimalarial\\ **Class / Subclass 2: ** DNA Damage, Repair and Replication / Intercalating Agent\\ **Class / Subclass 3: ** Proteostasis / Autophagy Inhibitor|
|iCRT14|[[results:exp492|exp492 (30µM)]]|Inhibits β-catenin-dependent transcription, may alter interaction of β-catenin with TCF4|**Class / Subclass 1: ** Gene Regulation / Transcription Inhibitor|
|IL-3|[[results:exp493|exp493 (9ng/mL)]]|Ligand for IL3RA receptor, induces myeloid lineage proliferation and differentiation|**Class / Subclass 1: ** Signal Transduction / Receptor Ligand|
|Isoniazid|[[results:exp494|exp494 (100µM)]]|Inhibits fatty acid synthases, pro-drug activated by catalase-peroxidase KatG|**Class / Subclass 1: ** Infectious Disease / Antibiotic|
|IWR-1-endo|[[results:exp495|exp495 (50µM)]]|Stabilizes axin complex, inhibits Wnt/β-catenin signaling, also inhibits tankyrase|**Class / Subclass 1: ** Signal Transduction / Other Inhibitor|
|Lead acetate|[[results:exp496|exp496 (990µM)]]\\ [[results:exp497|exp497 (2000µM)]]\\ [[results:exp498|exp498 (2000µM)]]|Industrial pollutant, heavy metal toxin|**Class / Subclass 1: ** Environmental Stresses / Heavy Metal|
|LY2090314|[[results:exp499|exp499 (3nM)]]\\ [[results:exp500|exp500 (3nM)]]|Inhibits glycogen synthase kinase-3 (GSK-3), activates Wnt signalling|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|Methotrexate|[[results:exp501|exp501 (10nM)]]|Inhibits dihydrofolate reductase (DHFR)|**Class / Subclass 1: ** Metabolism / Antimetabolite\\ **Class / Subclass 2: ** DNA Damage, Repair and Replication / Replication Inhibitor|
|Milciclib|[[results:exp502|exp502 (2µM)]]|Inhibits CDK2, also TRKA, CDK1, CDK4|**Class / Subclass 1: ** Cell Cycle / Cyclin Dependent Kinase Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|Mitomycin C|[[results:exp503|exp503 (60nM)]]|DNA crosslinker, reductive activation forms a mitosene that N-alkylates successively DNA bases|**Class / Subclass 1: ** DNA Damage, Repair and Replication / Inter/Intra-strand Crosslinker|
|MK2206|[[results:exp504|exp504 (4µM)]]|Inhibit Akt1, Akt2, Akt3|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|ML-792|[[results:exp505|exp505 (200nM)]]|Inhibits SUMO-activating enzyme (SAE)|**Class / Subclass 1: ** Proteostasis / SUMOylation Inhibitor|
|Momordin Ic|[[results:exp506|exp506 (10µM)]]|Triterpenoid saponin, putative SUMO-specific protease 1 (SENP1) inhibitor|**Class / Subclass 1: ** Uncharacterized Mechanism / Traditional Medicine\\ **Class / Subclass 2: ** Proteostasis / SUMOylation Inhibitor|
|Monensin|[[results:exp507|exp507 (300nM)]]|Polyether antibiotic, binds monovalent cations, Na+/H+ antiporter, blocks Golgi transport|**Class / Subclass 1: ** Infectious Disease / Antibiotic\\ **Class / Subclass 2: ** Organelle Function / Membrane Ionophore|
|N,N-Dimethylsphingosine|[[results:exp508|exp508 (2.5µM)]]|Inhibits sphingosine kinase, blocks sphingosine 1-phosphate (SPP) formation|**Class / Subclass 1: ** Metabolism / Metabolite\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|Nicotine|[[results:exp510|exp510 (3000µM)]]|Agonist for nicotinic acetylcholine receptors (nAChRs)|**Class / Subclass 1: ** Environmental Stresses / Psychoactive Drug\\ **Class / Subclass 2: ** Signal Transduction / Other Receptor Agonist|
|Olaparib|[[results:exp512|exp512 (4µM)]]|Inhibits PARP1 and PARP2, blocks ssDNA break repair, selectively toxic to BRCA1/2 negative cancers|**Class / Subclass 1: ** DNA Damage, Repair and Replication / PARP Inhibitor|
|ONC212|[[results:exp513|exp513 (150nM)]]|Inhibits mitochondrial CLPP protease, more potent derivative of TIC10/ONC201, possible agonist of GPR132|**Class / Subclass 1: ** Proteostasis / Protease Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / GPCR Agonist|
|Phorbol 12-myristate 13-acetate|[[results:exp514|exp514 (570nM)]]|Activates PKC isoforms, potent tumour promoter|**Class / Subclass 1: ** Signal Transduction / Kinase Activator|
|PU-H71|[[results:exp515|exp515 (1µM)]]|Inhibits HSP90|**Class / Subclass 1: ** Proteostasis / Chaperone Inhibitor|
|Pyrazinamide|[[results:exp516|exp516 (100µM)]]|Inhibits growth of Mycobacterium tuberculosis in combination with isoniazid, ethambutanol and rifampicin, converted to active pyrazinamide by pyrazinamidase|**Class / Subclass 1: ** Infectious Disease / Antibiotic|
|Quercetin|[[results:exp517|exp517 (20µM)]]|General kinase inhibitor, may inhibit NF-‘_B, anti-oxidant, putative senolytic|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor\\ **Class / Subclass 2: ** Gene Regulation / Transcription Inhibitor\\ **Class / Subclass 3: ** Uncharacterized Mechanism / Natural Product|
|RK-33|[[results:exp518|exp518 (8µM)]]|Inhibits DDX3 RNA helicase, causes G1 arrest and apoptosis, broad spectrum anti-viral|**Class / Subclass 1: ** Proteostasis / Translation Inhibitor\\ **Class / Subclass 2: ** Infectious Disease / Antiviral|
|RS-1|[[results:exp519|exp519 (10µM)]]|Activates DNA binding by RAD51|**Class / Subclass 1: ** DNA Damage, Repair and Replication / Repair Protein Activator|
|Rucaparib|[[results:exp520|exp520 (6.5µM)]]|PARP1/2/3 inhibitor (Clovis), PARP1 mediates single-strand break repair, which can lead to replication-induced double strand breaks to form if not repaired; specifically target cancer with BRCA1, BRCA2 or PALB2 mutations; FDA granted an accelerated approval for use in cases of pretreated advanced ovarian cancer|**Class / Subclass 1: ** DNA Damage, Repair and Replication / DNA Repair Inhibitor|
|Salinomycin|[[results:exp521|exp521 (3.5µM)]]|Potassium ionophore antibiotic, has activity against cancer stem cells|**Class / Subclass 1: ** Organelle Function / Membrane Ionophore|
|Staurosporine|[[results:exp524|exp524 (20nM)]]|Inhibits many protein kinases including PKC, PKA, tyrosine kinases, CDKs, others|**Class / Subclass 1: ** Signal Transduction / Kinase Inhibitor|
|Sulforaphane|[[results:exp525|exp525 (9µM)]]\\ [[results:exp526|exp526 (9µM)]]|Organosulfur compound, found in cruciferous plants|**Class / Subclass 1: ** Uncharacterized Mechanism / Natural Product|
|Tanespimycin|[[results:exp527|exp527 (14µM)]]|Inhibits HSP90, derivative of geldanamycin, a.k.a 17-AAG|**Class / Subclass 1: ** Proteostasis / Chaperone Inhibitor\\ **Class / Subclass 2: ** Infectious Disease / Antibiotic|
|TGF-β1|[[results:exp528|exp528 (44ng/mL)]]|Ligand for TGF-β1 receptor|**Class / Subclass 1: ** Signal Transduction / Other Receptor Agonist|
|Thimerosal|[[results:exp529|exp529 (850nM)]]|Organomercury compound, antiseptic and antifungal, approved preservative in vaccines|**Class / Subclass 1: ** Infectious Disease / Antifungal|
|Thioridazine|[[results:exp530|exp530 (5µM)]]|DRD2/4 selectivity, causes cardiac arrhythmia, also has antibiotic activity against M. tuberculosis|**Class / Subclass 1: ** Signal Transduction / GPCR Antagonist|
|THZ1|[[results:exp531|exp531 (60nM)]]|Inhibits CDK7, forms covalent adduct, blocks phosphorylation of the C-terminal domain of RNA polymerase II|**Class / Subclass 1: ** Gene Regulation / Transcription Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / Kinase Inhibitor|
|TIC10|[[results:exp532|exp532 (10µM)]]|Inhibits mitochondrial CLPP protease, a.k.a. ONC201, parent of ONC212, possible agonist of GPR132|**Class / Subclass 1: ** Proteostasis / Protease Inhibitor\\ **Class / Subclass 2: ** Signal Transduction / GPCR Agonist|
|TNF-α|[[results:exp533|exp533 (44ng/mL)]]|Ligand for TNFR1, induces apoptosis or necrosis|**Class / Subclass 1: ** Signal Transduction / Other Receptor Agonist|
|Trientine|[[results:exp534|exp534 (500µM)]]|Copper-selective chelator, enhances renal excretion of copper|**Class / Subclass 1: ** Environmental Stresses / Metal Chelator|
|Trimetrexate|[[results:exp535|exp535 (30nM)]]|Inhibits bacterial, protozoan, and mammalian dihydrofolate reductase (DHFR), methotrexate analog|**Class / Subclass 1: ** Metabolism / Antimetabolite\\ **Class / Subclass 2: ** DNA Damage, Repair and Replication / Replication Inhibitor\\ **Class / Subclass 3: ** Infectious Disease / Antibiotic|
|Vitamin D3|[[results:exp536|exp536 (40µM)]]|Steroid hormone, converted to active 1,25-dihydroxycholecalciferol (calcitriol), role in calcium homeostasis|**Class / Subclass 1: ** Metabolism / Vitamin\\ **Class / Subclass 2: ** Metabolism / Metabolite\\ **Class / Subclass 3: ** SIgnal Transduction / Receptor Ligand|
|WNT3A|[[results:exp537|exp537 (44ng/mL)]]|Ligand for Frizzled receptor complex, stabilizes ‘_-catenin, induces TCS/LEF-dependent transcription|**Class / Subclass 1: ** Signal Transduction / GPCR Agonist|
|ZLN024|[[results:exp538|exp538 (50µM)]]|Activates AMPK, allosteric|**Class / Subclass 1: ** Signal Transduction / Kinase Activator|
|Hypoxia 5% O2|[[results:exp191|exp191]]|Reduced growth oxygen|**Class / Subclass 1: ** Environmental Stresses / Stress Condition|
|35°C|[[results:exp302|exp302]]|Reduced growth temperature|**Class / Subclass 1: ** Environmental Stresses / Stress Condition|
|39°C|[[results:exp303|exp303]]|Elevated growth temperature|**Class / Subclass 1: ** Environmental Stresses / Stress Condition|
|FBS Sub-Optimal Growth|[[results:exp426|exp426 (10%)]]|Unknown, poor batch of FBS|**Class / Subclass 1: ** Environmental Stresses / Toxin|
|42°C|[[results:exp539|exp539]]|Elevated growth temperature|**Class / Subclass 1: ** Environmental Stresses / Stress Condition|