====== UM131593 0.2μM R03 exp106 ======
==== Mechanism of Action ====
Unknown
* **Class / Subclass 1:** Uncharacterized Mechanism / Chemical Screen Hit
==== Technical Notes ====
* **PubChem Name:** %%N/A%%
* **Synonyms:** N/A
* **CAS #:** N/A
* **PubChem CID:** N/A
* **IUPAC:** %%N/A%%
* **INCHI Name:** N/A
* **INCHI Key:** N/A
* **Molecular Weight:** 381.45
* **Canonical SMILES:** N/A
* **Isomeric SMILES:** N/A
* **Molecular Formula:** C21H19NO4S
{{:chemogenomics:structures:chem-0038.svg?nolink}}
* **Supplier Name:** In house - University of Montreal - Chemistry Platform
* **Catalog #:** N/A
* **Lot #:** IRIC-004 / sj2182-084 / Batch #01
Characterization data not available.
* **Platform ID:** UM0131593
* **Min:** 0.7950; **Max:** 83.0421
{{:chemogenomics:dose_response:dr_140.png?nolink&500 |}}
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^ IC ^ Concentration (µM) ^
| IC10 |N/A |
| IC20 |0.0217 |
| IC30 |0.0436 |
| IC40 |0.0772 |
| IC50 |0.1304 |
| IC60 |N/A |
| IC70 |N/A |
| IC80 |N/A |
| IC90 |N/A |
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==== Screen Summary ====
* **Round**: 03
* **Dose**: 200nM
* **Days of incubation**: 8
* **Doublings**: 1.2
* **Numbers of reads**: 12428553
==== Screen Results ====
^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|8/138|[[https://files.tyerslab.com/files/public/chemogenomics/cranks/UM131593_0.2uM_Round-3_exp106.txt|Scores]]||||||
{{:chemogenomics:cranks_plots:exp106.png?nolink}}
^Gene^CRANKS Score^FDR^
|[[:human_genes:P:PDS5B|PDS5B]]|-3.20|<0.01|
|[[:human_genes:P:PCGF1|PCGF1]]|-3.19|<0.01|
|[[:human_genes:I:ITFG2|ITFG2]]|-2.86|0.02|
|[[:human_genes:G:GNL2|GNL2]]|-2.84|0.03|
|[[:human_genes:R:RPL18|RPL18]]|-2.74|0.34|
|[[:human_genes:L:LRRC8A|LRRC8A]]|-2.74|0.02|
|[[:human_genes:E:ENO2|ENO2]]|-2.61|0.05|
|[[:human_genes:T:TUBGCP2|TUBGCP2]]|-2.60|0.05|
|[[:human_genes:W:WAPAL|WAPAL]]|-2.58|0.11|
|[[:human_genes:K:KATNA1|KATNA1]]|-2.55|0.05|
|[[:human_genes:H:HEXIM1|HEXIM1]]|-2.51|0.05|
|[[:human_genes:D:DLGAP5|DLGAP5]]|-2.49|0.05|
|[[:human_genes:M:MSI2|MSI2]]|-2.46|0.05|
|[[:human_genes:C:CENPW|CENPW]]|-2.37|0.12|
|[[:human_genes:S:SKIV2L2|SKIV2L2]]|-2.36|0.22|
|[[:human_genes:P:PSTK|PSTK]]|-2.36|0.08|
|[[:human_genes:F:FAM120A|FAM120A]]|-2.34|0.08|
|[[:human_genes:T:TNRC6C|TNRC6C]]|-2.24|0.15|
|[[:human_genes:R:RING1|RING1]]|-2.24|0.15|
|[[:human_genes:E:ESCO2|ESCO2]]|-2.24|0.12|
|[[:human_genes:Z:ZNF292|ZNF292]]|-2.23|0.12|
|[[:human_genes:H:HNRNPU|HNRNPU]]|-2.21|0.12|
|[[:human_genes:G:GPBP1|GPBP1]]|-2.20|0.16|
|[[:human_genes:C:C12orf43|C12orf43]]|-2.20|0.12|
|[[:human_genes:Y:YPEL5|YPEL5]]|-2.19|0.12|
|[[:human_genes:A:ACBD3|ACBD3]]|-2.19|0.22|
|[[:human_genes:N:NPIPA7|NPIPA7]]|-2.17|0.12|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.17|0.23|
|[[:human_genes:G:GAK|GAK]]|-2.16|0.12|
|[[:human_genes:N:NPIPA8|NPIPA8]]|-2.16|0.12|
|[[:human_genes:R:ROMO1|ROMO1]]|3.45|<0.01|
|[[:human_genes:T:TADA1|TADA1]]|3.48|<0.01|
|[[:human_genes:D:DHX29|DHX29]]|3.49|<0.01|
|[[:human_genes:M:MBTPS2|MBTPS2]]|3.51|<0.01|
|[[:human_genes:T:TAF5L|TAF5L]]|3.54|<0.01|
|[[:human_genes:M:MED13|MED13]]|3.66|<0.01|
|[[:human_genes:A:ALDH18A1|ALDH18A1]]|3.66|<0.01|
|[[:human_genes:P:PFN1|PFN1]]|3.68|<0.01|
|[[:human_genes:A:ARHGAP11B|ARHGAP11B]]|3.74|<0.01|
|[[:human_genes:B:BRPF1|BRPF1]]|3.86|<0.01|
|[[:human_genes:F:FBXO11|FBXO11]]|3.87|<0.01|
|[[:human_genes:D:DDX5|DDX5]]|3.89|<0.01|
|[[:human_genes:S:STK11|STK11]]|3.91|<0.01|
|[[:human_genes:M:MAX|MAX]]|3.98|<0.01|
|[[:human_genes:T:TRIM28|TRIM28]]|4.01|<0.01|
|[[:human_genes:S:SRF|SRF]]|4.02|<0.01|
|[[:human_genes:A:AMBRA1|AMBRA1]]|4.42|<0.01|
|[[:human_genes:P:PRKAR1A|PRKAR1A]]|4.77|<0.01|
|[[:human_genes:T:TP53|TP53]]|5.20|<0.01|
|[[:human_genes:N:NSD1|NSD1]]|5.68|<0.01|
|[[:human_genes:C:CBX3|CBX3]]|5.88|<0.01|
|[[:human_genes:S:SETDB1|SETDB1]]|5.91|<0.01|
|[[:human_genes:I:ID3|ID3]]|5.92|<0.01|
|[[:human_genes:K:KIF2C|KIF2C]]|5.95|<0.01|
|[[:human_genes:T:TMEM161B|TMEM161B]]|6.03|<0.01|
|[[:human_genes:A:ATP1A1|ATP1A1]]|6.19|<0.01|
|[[:human_genes:A:ATF7IP|ATF7IP]]|6.25|<0.01|
|[[:human_genes:N:NDRG3|NDRG3]]|6.65|<0.01|
|[[:human_genes:A:ATAT1|ATAT1]]|6.67|<0.01|
|[[:human_genes:K:KIF18B|KIF18B]]|7.08|<0.01|
^Screen^Correlation^Plot^
|[[:results:exp59|UMK57 1μM R01 exp59]]|0.14||
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|0.051||
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|0.172||
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|0.133||
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.106||
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.105||
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|0.096||
|[[:results:exp34|Rotenone 20μM R00 exp34]]|0.091||
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.09||
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.09||
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.085||
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|0.084||
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.08||
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.079||
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|0.077||
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.077||
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.076||
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.074||
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.071||
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.07||
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.068||
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|0.068||
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.067||
|[[:results:exp67|BVD-523 15μM R02 exp67]]|0.066||
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.066||
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|0.064||
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|0.063||
|[[:results:exp135|MS023 7μM R03 exp135]]|0.062||
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|0.062||
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.061||
|[[:results:exp539|42°C R08 exp539]]|0.061||
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|0.06||
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.059||
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.057||
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|0.055||
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|0.054||
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.053||
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.053||
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|0.052||
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.052||
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.052||
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|0.051||
{{:chemogenomics:comparison_plots:exp106_vs_exp59.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp108.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp460.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp217.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp2.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp3.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp175.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp34.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp478.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp503.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp472.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp312.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp440.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp350.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp211.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp451.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp80.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp517.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp28.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp199.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp228.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp500.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp67.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp515.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp290.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp215.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp135.png?nolink |}}
{{:chemogenomics:comparison_plots:exp103_vs_exp106.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp435.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp539.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp448.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp456.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp443.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp179.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp499.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp531.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp450.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp96.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp529.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp126.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp22.png?nolink |}}
No GO term hits below threshold. (FDR <0.05)
^GO Term^Fold Change^Genes^
|positive regulation of DNA methylation-dependent heterochromatin formation|165.79|ATF7IP,SETDB1,TRIM28|
|positive regulation of chromatin organization|127.53|ATF7IP,SETDB1,TRIM28|
|regulation of DNA methylation-dependent heterochromatin formation|97.52|ATF7IP,SETDB1,TRIM28|
|regulation of heterochromatin formation|72.08|ATF7IP,SETDB1,TRIM28|
|regulation of heterochromatin organization|72.08|ATF7IP,SETDB1,TRIM28|
|promoter-specific chromatin binding|34.01|SETDB1,TP53,TRIM28,DDX5|
|regulation of transcription initiation by RNA polymerase II|31.13|ATF7IP,TP53,SRF,MED13|
|regulation of DNA-templated transcription initiation|27.98|ATF7IP,TP53,SRF,MED13|
|positive regulation of cellular component biogenesis|8.95|ATAT1,ATF7IP,SETDB1,TP53,AMBRA1,SRF,TRIM28,PFN1|
|DNA-binding transcription factor binding|8.23|ID3,NSD1,TP53,SRF,MAX,DDX5,MED13|
|transcription factor binding|7.51|ID3,CBX3,NSD1,TP53,SRF,MAX,DDX5,MED13|
|transferase complex|6.01|PRKAR1A,AMBRA1,MAX,STK11,FBXO11,BRPF1,MED13,TAF5L,TADA1|