====== MS023 7μM R03 exp135 ======
==== Mechanism of Action ====
Inhibits protein arginine N-methyltransferase PRMT1
  * **<color #00a2e8>Class / Subclass 1:</color>** Gene Regulation / Epigenetic Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%MS023 (dihydrochloride)%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 1992047-64-9
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/121513886|121513886]]
    * **<color #00a2e8>IUPAC:</color>** %%N'-methyl-N'-[[4-(4-propan-2-yloxyphenyl)-1H-pyrrol-3-yl]methyl]ethane-1,2-diamine;dihydrochloride%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C17H25N3O.2ClH/c1-13(2)21-16-6-4-14(5-7-16)17-11-19-10-15(17)12-20(3)9-8-18;;/h4-7,10-11,13,19H,8-9,12,18H2,1-3H3;2*1H
    * **<color #00a2e8>INCHI Key:</color>** HCNXCUFNZWGILO-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 360.3
    * **<color #00a2e8>Canonical SMILES:</color>** CC(C)OC1=CC=C(C=C1)C2=CNC=C2CN(C)CCN.Cl.Cl
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C17H27Cl2N3O
{{:chemogenomics:structures:chem-0086.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Structural Genomics Consortium
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C17H25N3O 288.20704; found 288.20735
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** MS023
    * **<color #00a2e8>Min:</color>** -6.0031; **<color #00a2e8>Max:</color>** 44.7664
{{:chemogenomics:dose_response:dr_94.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |3.5114    |
| IC30  |7.8192    |
| IC40  |15.0721    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 03
    * **<color #00a2e8>Dose</color>**: 7µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 2.6
    * **<color #00a2e8>Numbers of reads</color>**: 13404640


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/90|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/MS023_7uM_Round-3_exp135.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='MS023 7μM R03 exp135'>
{{:chemogenomics:cranks_plots:exp135.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:U:USP39|USP39]]|-2.73|0.18|
|[[:human_genes:D:DRC1|DRC1]]|-2.72|0.11|
|[[:human_genes:C:CDC73|CDC73]]|-2.66|0.24|
|[[:human_genes:P:PSMD14|PSMD14]]|-2.47|0.56|
|[[:human_genes:N:NELFA|NELFA]]|-2.46|0.19|
|[[:human_genes:S:STK3|STK3]]|-2.42|0.18|
|[[:human_genes:P:PDZK1|PDZK1]]|-2.40|0.18|
|[[:human_genes:L:LRMP|LRMP]]|-2.36|0.24|
|[[:human_genes:N:NDC80|NDC80]]|-2.35|0.57|
|[[:human_genes:P:PTPN2|PTPN2]]|-2.34|0.19|
|[[:human_genes:A:ADAM10|ADAM10]]|-2.29|0.19|
|[[:human_genes:S:SNORD95|SNORD95]]|-2.28|0.26|
|[[:human_genes:R:RNF20|RNF20]]|-2.25|0.37|
|[[:human_genes:K:KCTD15|KCTD15]]|-2.23|0.27|
|[[:human_genes:A:ALMS1|ALMS1]]|-2.21|0.27|
|[[:human_genes:L:LLGL1|LLGL1]]|-2.21|0.24|
|[[:human_genes:Z:ZFAND5|ZFAND5]]|-2.19|0.24|
|[[:human_genes:E:EPB41L3|EPB41L3]]|-2.17|0.31|
|[[:human_genes:S:SCAF1|SCAF1]]|-2.14|0.63|
|[[:human_genes:S:SPATA5L1|SPATA5L1]]|-2.12|0.27|
|[[:human_genes:K:KIAA1614|KIAA1614]]|-2.11|0.37|
|[[:human_genes:C:CHCHD4|CHCHD4]]|-2.10|0.27|
|[[:human_genes:C:CA9|CA9]]|-2.08|0.27|
|[[:human_genes:P:POLD3|POLD3]]|-2.06|0.68|
|[[:human_genes:A:ADCY10|ADCY10]]|-2.06|0.42|
|[[:human_genes:T:TTC1|TTC1]]|-2.05|0.51|
|[[:human_genes:M:MED17|MED17]]|-2.03|0.44|
|[[:human_genes:E:EP300|EP300]]|-2.01|0.57|
|[[:human_genes:F:FAM173B|FAM173B]]|-2.01|0.36|
|[[:human_genes:G:GSTM5|GSTM5]]|-2.00|0.48|
|[[:human_genes:D:DPH5|DPH5]]|3.25|<0.01|
|[[:human_genes:M:METAP2|METAP2]]|3.31|<0.01|
|[[:human_genes:P:PRAMEF26|PRAMEF26]]|3.36|0.06|
|[[:human_genes:P:PRAMEF25|PRAMEF25]]|3.36|0.06|
|[[:human_genes:G:GNAS|GNAS]]|3.55|<0.01|
|[[:human_genes:H:HCCS|HCCS]]|3.64|<0.01|
|[[:human_genes:E:ELP6|ELP6]]|3.66|<0.01|
|[[:human_genes:D:DPH3|DPH3]]|3.73|<0.01|
|[[:human_genes:D:DIABLO|DIABLO]]|3.84|<0.01|
|[[:human_genes:T:TAF15|TAF15]]|3.85|<0.01|
|[[:human_genes:Z:ZZZ3|ZZZ3]]|3.97|<0.01|
|[[:human_genes:B:BCL2L11|BCL2L11]]|3.97|<0.01|
|[[:human_genes:M:MAPKAP1|MAPKAP1]]|4.01|<0.01|
|[[:human_genes:C:C7orf26|C7orf26]]|4.02|<0.01|
|[[:human_genes:E:EIF1AX|EIF1AX]]|4.08|<0.01|
|[[:human_genes:B:BPTF|BPTF]]|4.35|<0.01|
|[[:human_genes:C:CYCS|CYCS]]|4.41|<0.01|
|[[:human_genes:K:KDSR|KDSR]]|4.45|<0.01|
|[[:human_genes:R:ROMO1|ROMO1]]|4.49|<0.01|
|[[:human_genes:S:SERF2|SERF2]]|4.50|<0.01|
|[[:human_genes:K:KMT2D|KMT2D]]|4.60|<0.01|
|[[:human_genes:F:FAF2|FAF2]]|5.10|<0.01|
|[[:human_genes:D:DOHH|DOHH]]|5.37|<0.01|
|[[:human_genes:P:PLAA|PLAA]]|5.60|<0.01|
|[[:human_genes:C:CASP9|CASP9]]|5.94|<0.01|
|[[:human_genes:A:APAF1|APAF1]]|5.97|<0.01|
|[[:human_genes:U:UBQLN1|UBQLN1]]|6.33|<0.01|
|[[:human_genes:V:VDAC2|VDAC2]]|6.51|<0.01|
|[[:human_genes:M:MARCH5|MARCH5]]|6.52|<0.01|
|[[:human_genes:B:BAK1|BAK1]]|7.72|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.105|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.105|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.095|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.095|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.094|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.091|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.081|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.072|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.069|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.069|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|0.062|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.062|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|0.057|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|0.054|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|0.054|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|0.053|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|0.051|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.217|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.153|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.14|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.139|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.138|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.129|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.122|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.119|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.118|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.109|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.103|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.103|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.101|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.096|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.085|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.082|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|0.082|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.079|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.077|<button type="primary" size="small" modal="36">View</button>|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.073|<button type="primary" size="small" modal="37">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.069|<button type="primary" size="small" modal="38">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.066|<button type="primary" size="small" modal="39">View</button>|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.065|<button type="primary" size="small" modal="40">View</button>|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|0.065|<button type="primary" size="small" modal="41">View</button>|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.065|<button type="primary" size="small" modal="42">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.064|<button type="primary" size="small" modal="43">View</button>|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|0.062|<button type="primary" size="small" modal="44">View</button>|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|0.061|<button type="primary" size="small" modal="45">View</button>|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.06|<button type="primary" size="small" modal="46">View</button>|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|0.057|<button type="primary" size="small" modal="47">View</button>|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|0.056|<button type="primary" size="small" modal="48">View</button>|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.053|<button type="primary" size="small" modal="49">View</button>|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|0.051|<button type="primary" size="small" modal="50">View</button>|
</modal>


<modal id="1" size="lg" title="MS023 7μM R03 exp135  vs  Staurosporine 0.02μM R08 exp524">
{{:chemogenomics:comparison_plots:exp135_vs_exp524.png?nolink |}}
</modal>

<modal id="2" size="lg" title="MS023 7μM R03 exp135  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp135_vs_exp512.png?nolink |}}
</modal>

<modal id="3" size="lg" title="MS023 7μM R03 exp135  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp135_vs_exp503.png?nolink |}}
</modal>

<modal id="4" size="lg" title="MS023 7μM R03 exp135  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp135_vs_exp443.png?nolink |}}
</modal>

<modal id="5" size="lg" title="MS023 7μM R03 exp135  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp135_vs_exp531.png?nolink |}}
</modal>

<modal id="6" size="lg" title="MS023 7μM R03 exp135  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp135_vs_exp80.png?nolink |}}
</modal>

<modal id="7" size="lg" title="MS023 7μM R03 exp135  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp135_vs_exp28.png?nolink |}}
</modal>

<modal id="8" size="lg" title="MS023 7μM R03 exp135  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp135_vs_exp527.png?nolink |}}
</modal>

<modal id="9" size="lg" title="MS023 7μM R03 exp135  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp135_vs_exp85.png?nolink |}}
</modal>

<modal id="10" size="lg" title="MS023 7μM R03 exp135  vs  PU-H71 1μM R08 exp515">
{{:chemogenomics:comparison_plots:exp135_vs_exp515.png?nolink |}}
</modal>

<modal id="11" size="lg" title="MS023 7μM R03 exp135  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp135_vs_exp34.png?nolink |}}
</modal>

<modal id="12" size="lg" title="MS023 7μM R03 exp135  vs  UM131593 0.2μM R03 exp106">
{{:chemogenomics:comparison_plots:exp106_vs_exp135.png?nolink |}}
</modal>

<modal id="13" size="lg" title="MS023 7μM R03 exp135  vs  QNZ 0.01μM R08 exp439">
{{:chemogenomics:comparison_plots:exp135_vs_exp439.png?nolink |}}
</modal>

<modal id="14" size="lg" title="MS023 7μM R03 exp135  vs  Milciclib 2μM R08 exp502">
{{:chemogenomics:comparison_plots:exp135_vs_exp502.png?nolink |}}
</modal>

<modal id="15" size="lg" title="MS023 7μM R03 exp135  vs  Rotenone 0.07μM R08 exp431">
{{:chemogenomics:comparison_plots:exp135_vs_exp431.png?nolink |}}
</modal>

<modal id="16" size="lg" title="MS023 7μM R03 exp135  vs  Trimetrexate 0.03μM R08 exp535">
{{:chemogenomics:comparison_plots:exp135_vs_exp535.png?nolink |}}
</modal>

<modal id="17" size="lg" title="MS023 7μM R03 exp135  vs  Vinblastine 0.2μM R03 exp108">
{{:chemogenomics:comparison_plots:exp108_vs_exp135.png?nolink |}}
</modal>

<modal id="18" size="lg" title="MS023 2μM R03 exp134  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp134_vs_exp135.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Hippuristanol 0.12μM R08 exp489 no dilution day6  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp489.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Hippuristanol 0.12μM R08 exp488  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp488.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Benzoate 20000μM R08 exp456  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp456.png?nolink |}}
</modal>

<modal id="22" size="lg" title="Doxorubicin 0.02μM R08 exp478  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp478.png?nolink |}}
</modal>

<modal id="23" size="lg" title="AICAR 240μM R03 exp116  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp116_vs_exp135.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Etoposide 0.3μM R05 exp199  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp199.png?nolink |}}
</modal>

<modal id="25" size="lg" title="Bleomycin 5μM R08 exp459  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp459.png?nolink |}}
</modal>

<modal id="26" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp259.png?nolink |}}
</modal>

<modal id="27" size="lg" title="AICAR 240μM R05 exp211  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp211.png?nolink |}}
</modal>

<modal id="28" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp440.png?nolink |}}
</modal>

<modal id="29" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp3.png?nolink |}}
</modal>

<modal id="30" size="lg" title="CR131-b 0.005μM R08 exp474  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp474.png?nolink |}}
</modal>

<modal id="31" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp2.png?nolink |}}
</modal>

<modal id="32" size="lg" title="Artemisinin 50μM R08 exp450  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp450.png?nolink |}}
</modal>

<modal id="33" size="lg" title="JQ1 0.8μM R08 exp435  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp435.png?nolink |}}
</modal>

<modal id="34" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp214.png?nolink |}}
</modal>

<modal id="35" size="lg" title="CI-1040 9.5μM R08 exp472  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp472.png?nolink |}}
</modal>

<modal id="36" size="lg" title="MLN-4924 0.2μM R00 exp21  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp21.png?nolink |}}
</modal>

<modal id="37" size="lg" title="Atovaquone 15μM R08 exp451  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp451.png?nolink |}}
</modal>

<modal id="38" size="lg" title="Dorsomorphin 5μM R07 exp357  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp357.png?nolink |}}
</modal>

<modal id="39" size="lg" title="CB-5083 0.4μM R08 exp468  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp468.png?nolink |}}
</modal>

<modal id="40" size="lg" title="Etoposide 1μM R00 exp19  vs  MS023 7μM R03 exp135">
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</modal>

<modal id="41" size="lg" title="Latrunculin-B 10μM R07 exp374  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp374.png?nolink |}}
</modal>

<modal id="42" size="lg" title="Ethanol 0.01 R05 exp234  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp234.png?nolink |}}
</modal>

<modal id="43" size="lg" title="GSK626616 14μM R08 exp485  vs  MS023 7μM R03 exp135">
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</modal>

<modal id="44" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp448.png?nolink |}}
</modal>

<modal id="45" size="lg" title="Deferoxamine 11μM R07 exp350  vs  MS023 7μM R03 exp135">
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</modal>

<modal id="46" size="lg" title="GSK461364A 0.1μM R03 exp126  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp126_vs_exp135.png?nolink |}}
</modal>

<modal id="47" size="lg" title="BI-2536 0.02μM R03 exp96  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp96.png?nolink |}}
</modal>

<modal id="48" size="lg" title="ML-792 0.2μM R08 exp505  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp505.png?nolink |}}
</modal>

<modal id="49" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp500.png?nolink |}}
</modal>

<modal id="50" size="lg" title="BI-6727 0.04μM R03 exp98  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp98.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|apoptosome|552.63|APAF1,CASP9|
|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|442.11|APAF1,CASP9,CYCS,DIABLO|
|elongator holoenzyme complex|221.05|ELP6,ELP2|
|protein histidyl modification to diphthamide|221.05|DPH3,DPH5|
|porin activity|221.05|BAK1,VDAC2|
|tRNA wobble uridine modification|103.62|DPH3,ELP6,ELP2|
|positive regulation of mitochondrial membrane permeability|59.21|BAK1,VDAC2,BCL2L11|
|positive regulation of membrane permeability|53.48|BAK1,VDAC2,BCL2L11|
|positive regulation of response to endoplasmic reticulum stress|47.37|BAK1,UBQLN1,BCL2L11|
|positive regulation of cysteine-type endopeptidase activity|22.46|BAK1,APAF1,CASP9,CYCS,DIABLO|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|21.05|APAF1,CASP9,CYCS,DIABLO|
|mitochondrial membrane organization|20.85|BAK1,VDAC2,ROMO1,BCL2L11|
|intrinsic apoptotic signaling pathway|20.72|BAK1,APAF1,CASP9,CYCS,BCL2L11,DIABLO|
|positive regulation of endopeptidase activity|19.19|BAK1,APAF1,CASP9,CYCS,DIABLO|
|positive regulation of peptidase activity|17.49|BAK1,APAF1,CASP9,CYCS,DIABLO|
|regulation of cysteine-type endopeptidase activity|14.78|BAK1,APAF1,CASP9,CYCS,DIABLO|
|apoptotic signaling pathway|12.56|BAK1,VDAC2,APAF1,CASP9,CYCS,BCL2L11,DIABLO|
|positive regulation of proteolysis|9.87|BAK1,UBQLN1,APAF1,CASP9,CYCS,DIABLO|
|mitochondrial envelope|5.88|BAK1,MARCHF5,VDAC2,ROMO1,CYCS,BCL2L11,DIABLO,HCCS|
</modal>