====== AICAR 240μM R05 exp211 ======
==== Mechanism of Action ====
Metabolic intermediate in purine biosynthesis, activates AMPK, has other putative targets
  * **<color #00a2e8>Class / Subclass 1:</color>** Metabolism / Metabolite
  * **<color #00a2e8>Class / Subclass 2:</color>** Signal Transduction / Kinase Activator



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Acadesine%%
    * **<color #00a2e8>Synonyms:</color>** Acadesine; AICA Riboside
    * **<color #00a2e8>CAS #:</color>** 2627-69-2
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/17513|17513]]
    * **<color #00a2e8>IUPAC:</color>** %%5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carboxamide%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
    * **<color #00a2e8>INCHI Key:</color>** RTRQQBHATOEIAF-UUOKFMHZSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 258.23
    * **<color #00a2e8>Canonical SMILES:</color>** C1=NC(=C(N1C2C(C(C(O2)CO)O)O)N)C(=O)N
    * **<color #00a2e8>Isomeric SMILES:</color>** C1=NC(=C(N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N)C(=O)N
    * **<color #00a2e8>Molecular Formula:</color>** C9H14N4O5
{{:chemogenomics:structures:chem-0072.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** AK scientific
    * **<color #00a2e8>Catalog #:</color>** AMTNS043
    * **<color #00a2e8>Lot #:</color>** DM-079-143-2
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>LCMS:</color>** Tr 0.15 min, m/z 259+ [M+H]+, 257- [M-H]-
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** AICAR
    * **<color #00a2e8>Min:</color>** -11.2747; **<color #00a2e8>Max:</color>** 24.1473
{{:chemogenomics:dose_response:dr_68.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 05
    * **<color #00a2e8>Dose</color>**: 240µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 1.5
    * **<color #00a2e8>Numbers of reads</color>**: 17899422


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|1/115|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/AICAR_240uM_Round-5_exp211.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='AICAR 240μM R05 exp211'>
{{:chemogenomics:cranks_plots:exp211.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:U:UCK2|UCK2]]|-4.28|<0.01|
|[[:human_genes:R:RPL30|RPL30]]|-2.80|0.37|
|[[:human_genes:S:SKIV2L2|SKIV2L2]]|-2.70|0.39|
|[[:human_genes:U:UGDH|UGDH]]|-2.68|0.06|
|[[:human_genes:N:NPRL2|NPRL2]]|-2.64|0.06|
|[[:human_genes:U:USP5|USP5]]|-2.63|0.10|
|[[:human_genes:C:CREBBP|CREBBP]]|-2.60|0.10|
|[[:human_genes:P:PPP1R18|PPP1R18]]|-2.48|0.26|
|[[:human_genes:G:GNL3|GNL3]]|-2.47|0.20|
|[[:human_genes:N:NUP133|NUP133]]|-2.43|0.26|
|[[:human_genes:D:DNAH3|DNAH3]]|-2.41|0.19|
|[[:human_genes:S:SUPT3H|SUPT3H]]|-2.40|0.10|
|[[:human_genes:T:TK1|TK1]]|-2.40|0.10|
|[[:human_genes:R:RPS13|RPS13]]|-2.27|0.44|
|[[:human_genes:N:NIPBL|NIPBL]]|-2.27|0.26|
|[[:human_genes:T:TRIM44|TRIM44]]|-2.27|0.20|
|[[:human_genes:Z:ZNF259|ZNF259]]|-2.26|0.20|
|[[:human_genes:H:HMGCS1|HMGCS1]]|-2.21|0.28|
|[[:human_genes:Y:YBX3|YBX3]]|-2.21|0.25|
|[[:human_genes:D:DTYMK|DTYMK]]|-2.20|0.25|
|[[:human_genes:S:SRSF10|SRSF10]]|-2.19|0.29|
|[[:human_genes:U:UBE2D3|UBE2D3]]|-2.19|0.20|
|[[:human_genes:T:TRIM66|TRIM66]]|-2.19|0.20|
|[[:human_genes:K:KRTAP4-8|KRTAP4-8]]|-2.18|0.35|
|[[:human_genes:M:MIER3|MIER3]]|-2.16|0.20|
|[[:human_genes:C:CHMP6|CHMP6]]|-2.16|0.26|
|[[:human_genes:F:F7|F7]]|-2.15|0.20|
|[[:human_genes:C:COX7A2|COX7A2]]|-2.15|0.20|
|[[:human_genes:C:CMPK1|CMPK1]]|-2.15|0.20|
|[[:human_genes:L:LSM6|LSM6]]|-2.14|0.30|
|[[:human_genes:L:LIAS|LIAS]]|3.38|<0.01|
|[[:human_genes:A:ATIC|ATIC]]|3.38|<0.01|
|[[:human_genes:M:MAPKAP1|MAPKAP1]]|3.38|<0.01|
|[[:human_genes:G:GUK1|GUK1]]|3.41|<0.01|
|[[:human_genes:F:FDX1|FDX1]]|3.42|<0.01|
|[[:human_genes:M:MARCH5|MARCH5]]|3.44|<0.01|
|[[:human_genes:M:MLX|MLX]]|3.49|<0.01|
|[[:human_genes:M:MLST8|MLST8]]|3.53|<0.01|
|[[:human_genes:A:APAF1|APAF1]]|3.61|<0.01|
|[[:human_genes:H:HEATR3|HEATR3]]|3.65|<0.01|
|[[:human_genes:T:TP53|TP53]]|3.95|<0.01|
|[[:human_genes:B:BAK1|BAK1]]|3.97|<0.01|
|[[:human_genes:S:SLC25A51|SLC25A51]]|4.28|<0.01|
|[[:human_genes:M:MTRR|MTRR]]|4.37|<0.01|
|[[:human_genes:P:PRUNE|PRUNE]]|4.55|<0.01|
|[[:human_genes:M:MTHFD1L|MTHFD1L]]|4.89|<0.01|
|[[:human_genes:M:MTR|MTR]]|4.96|<0.01|
|[[:human_genes:D:DLD|DLD]]|4.99|<0.01|
|[[:human_genes:Y:YLPM1|YLPM1]]|5.03|<0.01|
|[[:human_genes:S:SLC29A1|SLC29A1]]|5.11|<0.01|
|[[:human_genes:S:SLC19A1|SLC19A1]]|5.15|<0.01|
|[[:human_genes:A:ADSS|ADSS]]|5.35|<0.01|
|[[:human_genes:M:MMACHC|MMACHC]]|5.43|<0.01|
|[[:human_genes:M:MTHFD2|MTHFD2]]|5.45|<0.01|
|[[:human_genes:S:SHMT2|SHMT2]]|5.57|<0.01|
|[[:human_genes:S:SLC25A32|SLC25A32]]|6.31|<0.01|
|[[:human_genes:I:IMPDH2|IMPDH2]]|7.40|<0.01|
|[[:human_genes:A:AK2|AK2]]|8.09|<0.01|
|[[:human_genes:N:NUDT2|NUDT2]]|8.48|<0.01|
|[[:human_genes:A:ADK|ADK]]|8.50|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.128|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.115|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.111|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp135|MS023 7μM R03 exp135]]|0.109|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.104|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.101|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.098|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.097|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.094|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.091|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.09|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.087|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.087|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.081|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.08|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.079|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|0.078|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.077|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.076|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.075|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|0.074|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.073|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.071|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.071|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.07|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|0.07|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.068|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.068|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.066|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.066|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|0.065|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|0.064|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.063|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.062|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.061|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|0.061|<button type="primary" size="small" modal="36">View</button>|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|0.061|<button type="primary" size="small" modal="37">View</button>|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|0.06|<button type="primary" size="small" modal="38">View</button>|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.058|<button type="primary" size="small" modal="39">View</button>|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|0.057|<button type="primary" size="small" modal="40">View</button>|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|0.057|<button type="primary" size="small" modal="41">View</button>|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.057|<button type="primary" size="small" modal="42">View</button>|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|0.054|<button type="primary" size="small" modal="43">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.053|<button type="primary" size="small" modal="44">View</button>|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|0.052|<button type="primary" size="small" modal="45">View</button>|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|0.052|<button type="primary" size="small" modal="46">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.051|<button type="primary" size="small" modal="47">View</button>|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|0.051|<button type="primary" size="small" modal="48">View</button>|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|0.051|<button type="primary" size="small" modal="49">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.209|<button type="primary" size="small" modal="50">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.114|<button type="primary" size="small" modal="51">View</button>|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.076|<button type="primary" size="small" modal="52">View</button>|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|0.051|<button type="primary" size="small" modal="53">View</button>|
</modal>


<modal id="1" size="lg" title="AICAR 240μM R05 exp211  vs  Benzoate 20000μM R08 exp456">
{{:chemogenomics:comparison_plots:exp211_vs_exp456.png?nolink |}}
</modal>

<modal id="2" size="lg" title="AICAR 240μM R05 exp211  vs  Aphidicolin 0.4μM R08 exp440">
{{:chemogenomics:comparison_plots:exp211_vs_exp440.png?nolink |}}
</modal>

<modal id="3" size="lg" title="AICAR 240μM R05 exp211  vs  Actinomycin-D 0.001μM R00 exp3">
{{:chemogenomics:comparison_plots:exp211_vs_exp3.png?nolink |}}
</modal>

<modal id="4" size="lg" title="AICAR 240μM R05 exp211  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp211.png?nolink |}}
</modal>

<modal id="5" size="lg" title="AICAR 240μM R05 exp211  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp211_vs_exp512.png?nolink |}}
</modal>

<modal id="6" size="lg" title="AICAR 240μM R05 exp211  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp211.png?nolink |}}
</modal>

<modal id="7" size="lg" title="AICAR 240μM R05 exp211  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp211_vs_exp503.png?nolink |}}
</modal>

<modal id="8" size="lg" title="AICAR 240μM R05 exp211  vs  Atovaquone 15μM R08 exp451">
{{:chemogenomics:comparison_plots:exp211_vs_exp451.png?nolink |}}
</modal>

<modal id="9" size="lg" title="AICAR 240μM R05 exp211  vs  MS023 2μM R03 exp134">
{{:chemogenomics:comparison_plots:exp134_vs_exp211.png?nolink |}}
</modal>

<modal id="10" size="lg" title="AICAR 240μM R05 exp211  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp211_vs_exp80.png?nolink |}}
</modal>

<modal id="11" size="lg" title="AICAR 240μM R05 exp211  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp211_vs_exp531.png?nolink |}}
</modal>

<modal id="12" size="lg" title="AICAR 240μM R05 exp211  vs  Doxorubicin 0.02μM R08 exp478">
{{:chemogenomics:comparison_plots:exp211_vs_exp478.png?nolink |}}
</modal>

<modal id="13" size="lg" title="AICAR 240μM R05 exp211  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp211_vs_exp485.png?nolink |}}
</modal>

<modal id="14" size="lg" title="AICAR 240μM R05 exp211  vs  CI-1040 9.5μM R08 exp472">
{{:chemogenomics:comparison_plots:exp211_vs_exp472.png?nolink |}}
</modal>

<modal id="15" size="lg" title="AICAR 240μM R05 exp211  vs  CR131-b 0.005μM R08 exp474">
{{:chemogenomics:comparison_plots:exp211_vs_exp474.png?nolink |}}
</modal>

<modal id="16" size="lg" title="AICAR 240μM R05 exp211  vs  Bleomycin 5μM R08 exp459">
{{:chemogenomics:comparison_plots:exp211_vs_exp459.png?nolink |}}
</modal>

<modal id="17" size="lg" title="AICAR 240μM R05 exp211  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp211_vs_exp34.png?nolink |}}
</modal>

<modal id="18" size="lg" title="AICAR 240μM R05 exp211  vs  UM131593 0.2μM R03 exp106">
{{:chemogenomics:comparison_plots:exp106_vs_exp211.png?nolink |}}
</modal>

<modal id="19" size="lg" title="AICAR 240μM R05 exp211  vs  Artemisinin 50μM R08 exp450">
{{:chemogenomics:comparison_plots:exp211_vs_exp450.png?nolink |}}
</modal>

<modal id="20" size="lg" title="AICAR 240μM R05 exp211  vs  Staurosporine 0.02μM R08 exp524">
{{:chemogenomics:comparison_plots:exp211_vs_exp524.png?nolink |}}
</modal>

<modal id="21" size="lg" title="AICAR 240μM R05 exp211  vs  Nutlin-3A 1.6μM R06 exp294">
{{:chemogenomics:comparison_plots:exp211_vs_exp294.png?nolink |}}
</modal>

<modal id="22" size="lg" title="AICAR 240μM R05 exp211  vs  Hippuristanol 0.12μM R08 exp488">
{{:chemogenomics:comparison_plots:exp211_vs_exp488.png?nolink |}}
</modal>

<modal id="23" size="lg" title="AICAR 240μM R05 exp211  vs  Etoposide 1μM R00 exp19">
{{:chemogenomics:comparison_plots:exp19_vs_exp211.png?nolink |}}
</modal>

<modal id="24" size="lg" title="AICAR 240μM R05 exp211  vs  PU-H71 1μM R08 exp515">
{{:chemogenomics:comparison_plots:exp211_vs_exp515.png?nolink |}}
</modal>

<modal id="25" size="lg" title="AICAR 240μM R05 exp211  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp211_vs_exp527.png?nolink |}}
</modal>

<modal id="26" size="lg" title="AICAR 240μM R05 exp211  vs  ML-792 0.2μM R08 exp505">
{{:chemogenomics:comparison_plots:exp211_vs_exp505.png?nolink |}}
</modal>

<modal id="27" size="lg" title="AICAR 240μM R05 exp211  vs  Hippuristanol 0.12μM R08 exp489 no dilution day6">
{{:chemogenomics:comparison_plots:exp211_vs_exp489.png?nolink |}}
</modal>

<modal id="28" size="lg" title="AICAR 240μM R05 exp211  vs  Thimerosal 0.85μM R08 exp529">
{{:chemogenomics:comparison_plots:exp211_vs_exp529.png?nolink |}}
</modal>

<modal id="29" size="lg" title="AICAR 240μM R05 exp211  vs  MLN-4924 0.2μM R00 exp21">
{{:chemogenomics:comparison_plots:exp21_vs_exp211.png?nolink |}}
</modal>

<modal id="30" size="lg" title="AICAR 240μM R05 exp211  vs  JQ1 0.8μM R08 exp435">
{{:chemogenomics:comparison_plots:exp211_vs_exp435.png?nolink |}}
</modal>

<modal id="31" size="lg" title="AICAR 240μM R05 exp211  vs  Ammonium tetrathiomolybdate 10μM R08 exp448">
{{:chemogenomics:comparison_plots:exp211_vs_exp448.png?nolink |}}
</modal>

<modal id="32" size="lg" title="AICAR 240μM R05 exp211  vs  Deferoxamine 11μM R07 exp350">
{{:chemogenomics:comparison_plots:exp211_vs_exp350.png?nolink |}}
</modal>

<modal id="33" size="lg" title="AICAR 240μM R05 exp211  vs  GSK-J4 1.5μM R08 exp441">
{{:chemogenomics:comparison_plots:exp211_vs_exp441.png?nolink |}}
</modal>

<modal id="34" size="lg" title="AICAR 240μM R05 exp211  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp211_vs_exp443.png?nolink |}}
</modal>

<modal id="35" size="lg" title="AICAR 240μM R05 exp211  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp211_vs_exp28.png?nolink |}}
</modal>

<modal id="36" size="lg" title="AICAR 240μM R05 exp211  vs  Diepoxybutane 3μM R07 exp354">
{{:chemogenomics:comparison_plots:exp211_vs_exp354.png?nolink |}}
</modal>

<modal id="37" size="lg" title="AICAR 240μM R05 exp211  vs  Latrunculin-B 10μM R07 exp374">
{{:chemogenomics:comparison_plots:exp211_vs_exp374.png?nolink |}}
</modal>

<modal id="38" size="lg" title="AICAR 240μM R05 exp211  vs  TRAIL 5ng/ml R00 exp35">
{{:chemogenomics:comparison_plots:exp211_vs_exp35.png?nolink |}}
</modal>

<modal id="39" size="lg" title="AICAR 240μM R05 exp211  vs  Ethanol 0.01 R05 exp234">
{{:chemogenomics:comparison_plots:exp211_vs_exp234.png?nolink |}}
</modal>

<modal id="40" size="lg" title="AICAR 240μM R05 exp211  vs  Dinaciclib 0.007μM R07 exp355">
{{:chemogenomics:comparison_plots:exp211_vs_exp355.png?nolink |}}
</modal>

<modal id="41" size="lg" title="AICAR 240μM R05 exp211  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp211_vs_exp329.png?nolink |}}
</modal>

<modal id="42" size="lg" title="AICAR 240μM R05 exp211  vs  LY2090314 0.003μM R08 exp500 no dilution day6">
{{:chemogenomics:comparison_plots:exp211_vs_exp500.png?nolink |}}
</modal>

<modal id="43" size="lg" title="AICAR 240μM R05 exp211  vs  TRAIL 50ng/ml R00 exp36">
{{:chemogenomics:comparison_plots:exp211_vs_exp36.png?nolink |}}
</modal>

<modal id="44" size="lg" title="AICAR 240μM R05 exp211  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp211_vs_exp85.png?nolink |}}
</modal>

<modal id="45" size="lg" title="AICAR 240μM R05 exp211  vs  LY2090314 0.003μM R08 exp499">
{{:chemogenomics:comparison_plots:exp211_vs_exp499.png?nolink |}}
</modal>

<modal id="46" size="lg" title="AICAR 240μM R05 exp211  vs  Arsenate 40μM R06 exp264">
{{:chemogenomics:comparison_plots:exp211_vs_exp264.png?nolink |}}
</modal>

<modal id="47" size="lg" title="AICAR 240μM R05 exp211  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp211_vs_exp468.png?nolink |}}
</modal>

<modal id="48" size="lg" title="AICAR 240μM R05 exp211  vs  Tozasertib 0.1μM R07 exp414">
{{:chemogenomics:comparison_plots:exp211_vs_exp414.png?nolink |}}
</modal>

<modal id="49" size="lg" title="AICAR 240μM R05 exp211  vs  Rotenone 0.07μM R08 exp431">
{{:chemogenomics:comparison_plots:exp211_vs_exp431.png?nolink |}}
</modal>

<modal id="50" size="lg" title="AICAR 240μM R03 exp116  vs  AICAR 240μM R05 exp211">
{{:chemogenomics:comparison_plots:exp116_vs_exp211.png?nolink |}}
</modal>

<modal id="51" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  AICAR 240μM R05 exp211">
{{:chemogenomics:comparison_plots:exp2_vs_exp211.png?nolink |}}
</modal>

<modal id="52" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  AICAR 240μM R05 exp211">
{{:chemogenomics:comparison_plots:exp211_vs_exp259.png?nolink |}}
</modal>

<modal id="53" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  AICAR 240μM R05 exp211">
{{:chemogenomics:comparison_plots:exp211_vs_exp214.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|thymidine metabolic process|285.69|TK1,DTYMK|
|nucleoside kinase activity|214.27|UCK2,TK1,CMPK1|
|pyrimidine nucleotide biosynthetic process|57.14|UCK2,DTYMK,CMPK1|
|pyrimidine-containing compound biosynthetic process|57.14|UCK2,TK1,DTYMK,CMPK1|
|nucleobase-containing compound kinase activity|55.74|UCK2,TK1,DTYMK,CMPK1|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|tetrahydrofolate metabolic process|197.26|SHMT2,MTHFD2,MTR,MTHFD1L,ATIC|
|AMP biosynthetic process|184.11|ADK,NUDT2,ADSS2,ATIC|
|folic acid-containing compound metabolic process|154.65|SHMT2,MTHFD2,SLC19A1,MTR,MTHFD1L,MTRR,ATIC|
|purine ribonucleoside monophosphate biosynthetic process|153.43|ADK,NUDT2,IMPDH2,ADSS2,ATIC|
|pteridine-containing compound metabolic process|142.54|SLC25A32,SHMT2,MTHFD2,SLC19A1,MTR,MTHFD1L,MTRR,ATIC|
|purine nucleoside monophosphate biosynthetic process|138.08|ADK,NUDT2,IMPDH2,ADSS2,ATIC|
|purine ribonucleoside monophosphate metabolic process|96.66|ADK,NUDT2,AK2,IMPDH2,ADSS2,GUK1,ATIC|
|purine nucleoside monophosphate metabolic process|92.06|ADK,NUDT2,AK2,IMPDH2,ADSS2,GUK1,ATIC|
|ribonucleoside monophosphate biosynthetic process|81.23|ADK,NUDT2,IMPDH2,ADSS2,ATIC|
|water-soluble vitamin metabolic process|66.66|SLC25A32,SHMT2,MTHFD2,MMACHC,SLC19A1,MTR,MTRR|
|ribonucleoside monophosphate metabolic process|65.53|ADK,NUDT2,AK2,IMPDH2,ADSS2,GUK1,ATIC|
|nucleoside monophosphate metabolic process|50.87|ADK,NUDT2,AK2,IMPDH2,ADSS2,GUK1,ATIC|
|dicarboxylic acid metabolic process|50.21|SLC25A32,SHMT2,MTHFD2,ADSS2,SLC19A1,MTHFD1L,MTRR,ATIC|
|vitamin metabolic process|39.86|SLC25A32,SHMT2,MTHFD2,MMACHC,SLC19A1,MTR,MTRR|
|cellular modified amino acid metabolic process|38.76|SLC25A32,SHMT2,MTHFD2,SLC19A1,MTR,MTHFD1L,MTRR,ATIC|
|purine-containing compound biosynthetic process|22.49|ADK,NUDT2,AK2,IMPDH2,SHMT2,ADSS2,DLD,GUK1,ATIC|
|purine nucleotide biosynthetic process|20.84|ADK,NUDT2,AK2,IMPDH2,ADSS2,DLD,GUK1,ATIC|
|carboxylic acid metabolic process|8.21|SLC25A32,SHMT2,MTHFD2,ADSS2,SLC19A1,DLD,MTR,MTHFD1L,MTRR,TP53,ATIC,LIAS|
|oxoacid metabolic process|8.00|SLC25A32,SHMT2,MTHFD2,ADSS2,SLC19A1,DLD,MTR,MTHFD1L,MTRR,TP53,ATIC,LIAS|
</modal>