====== CB-839 10μM R05 exp224 ======
==== Mechanism of Action ====
Inhibits glutaminase (GLS1), reversible
  * **<color #00a2e8>Class / Subclass 1:</color>** Metabolism / Metabolic Enzyme Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%CB-839%%
    * **<color #00a2e8>Synonyms:</color>** CB-839
    * **<color #00a2e8>CAS #:</color>** 1439399-58-2
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/71577426|71577426]]
    * **<color #00a2e8>IUPAC:</color>** %%N-[6-[4-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]butyl]pyridazin-3-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34-21)7-1-2-10-24-35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7,10,15-16H2,(H,31,34,37)(H,32,36,38)
    * **<color #00a2e8>INCHI Key:</color>** PRAAPINBUWJLGA-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 571.6
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC=NC(=C1)CC(=O)NC2=NN=C(S2)CCCCC3=NN=C(C=C3)NC(=O)CC4=CC(=CC=C4)OC(F)(F)F
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C26H24F3N7O3S
{{:chemogenomics:structures:chem-0129.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** N/A
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C26H24F3N7O3S 572.16862; found 572.17021
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** CB-839
    * **<color #00a2e8>Min:</color>** -29.0403; **<color #00a2e8>Max:</color>** 20.4182
{{:chemogenomics:dose_response:dr_258.png?nolink&500 |}}
\\ 
\\ 
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 05
    * **<color #00a2e8>Dose</color>**: 10µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 4.3
    * **<color #00a2e8>Numbers of reads</color>**: 17648881


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|4/5|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/CB-839_10uM_Round-5_exp224.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='CB-839 10μM R05 exp224'>
{{:chemogenomics:cranks_plots:exp224.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:W:WSB1|WSB1]]|-4.01|<0.01|
|[[:human_genes:F:FASTKD1|FASTKD1]]|-3.35|<0.01|
|[[:human_genes:L:LAMTOR4|LAMTOR4]]|-3.18|<0.01|
|[[:human_genes:F:FLVCR1|FLVCR1]]|-3.03|<0.01|
|[[:human_genes:M:MDH2|MDH2]]|-2.57|0.05|
|[[:human_genes:U:UBA1|UBA1]]|-2.55|0.29|
|[[:human_genes:C:CHKA|CHKA]]|-2.51|0.06|
|[[:human_genes:T:TCEA1|TCEA1]]|-2.48|0.11|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-2.45|0.07|
|[[:human_genes:M:MSI2|MSI2]]|-2.42|0.08|
|[[:human_genes:N:NDUFB3|NDUFB3]]|-2.33|0.16|
|[[:human_genes:S:SOX4|SOX4]]|-2.28|0.24|
|[[:human_genes:E:EDC3|EDC3]]|-2.27|0.14|
|[[:human_genes:G:GPR107|GPR107]]|-2.26|0.14|
|[[:human_genes:I:IL15|IL15]]|-2.25|0.18|
|[[:human_genes:U:UXS1|UXS1]]|-2.23|0.16|
|[[:human_genes:F:FKBP5|FKBP5]]|-2.18|0.16|
|[[:human_genes:C:C12orf66|C12orf66]]|-2.18|0.16|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.17|0.31|
|[[:human_genes:T:TCF4|TCF4]]|-2.15|0.17|
|[[:human_genes:T:TCF12|TCF12]]|-2.15|0.24|
|[[:human_genes:S:SCYL1|SCYL1]]|-2.14|0.17|
|[[:human_genes:D:DYNLRB1|DYNLRB1]]|-2.13|0.17|
|[[:human_genes:C:CRABP1|CRABP1]]|-2.13|0.17|
|[[:human_genes:E:ENTPD2|ENTPD2]]|-2.12|0.35|
|[[:human_genes:A:ARHGEF28|ARHGEF28]]|-2.10|0.19|
|[[:human_genes:N:NUDT5|NUDT5]]|-2.08|0.27|
|[[:human_genes:R:RAD1|RAD1]]|-2.06|0.23|
|[[:human_genes:A:AP4B1|AP4B1]]|-2.05|0.29|
|[[:human_genes:T:TSC2|TSC2]]|-2.02|0.24|
|[[:human_genes:C:CD48|CD48]]|1.99|0.44|
|[[:human_genes:H:HNRNPAB|HNRNPAB]]|1.99|0.44|
|[[:human_genes:C:CCDC116|CCDC116]]|2.01|0.48|
|[[:human_genes:D:DGAT1|DGAT1]]|2.02|0.48|
|[[:human_genes:I:INTS5|INTS5]]|2.02|0.53|
|[[:human_genes:A:AATF|AATF]]|2.03|0.48|
|[[:human_genes:T:TTC4|TTC4]]|2.04|0.38|
|[[:human_genes:S:SIGIRR|SIGIRR]]|2.05|0.48|
|[[:human_genes:P:PSMD11|PSMD11]]|2.06|0.44|
|[[:human_genes:T:TIMM8A|TIMM8A]]|2.08|0.44|
|[[:human_genes:L:LAS1L|LAS1L]]|2.12|0.54|
|[[:human_genes:C:CEP95|CEP95]]|2.15|0.48|
|[[:human_genes:R:RRM2|RRM2]]|2.23|0.63|
|[[:human_genes:R:RBM38|RBM38]]|2.27|0.14|
|[[:human_genes:U:U2AF2|U2AF2]]|2.28|0.48|
|[[:human_genes:D:DONSON|DONSON]]|2.28|0.62|
|[[:human_genes:E:EIF3G|EIF3G]]|2.31|0.38|
|[[:human_genes:S:SLC7A1|SLC7A1]]|2.31|0.48|
|[[:human_genes:K:KMT2D|KMT2D]]|2.34|0.11|
|[[:human_genes:S:SLC25A32|SLC25A32]]|2.41|0.14|
|[[:human_genes:G:GLS|GLS]]|2.50|0.05|
|[[:human_genes:P:PELP1|PELP1]]|2.59|0.27|
|[[:human_genes:C:C9orf69|C9orf69]]|2.60|0.07|
|[[:human_genes:D:DTL|DTL]]|2.69|0.18|
|[[:human_genes:R:RCOR1|RCOR1]]|2.76|0.02|
|[[:human_genes:C:CCNA2|CCNA2]]|2.86|0.05|
|[[:human_genes:T:TBRG4|TBRG4]]|3.01|0.01|
|[[:human_genes:M:MLST8|MLST8]]|3.37|<0.01|
|[[:human_genes:M:ME2|ME2]]|3.43|<0.01|
|[[:human_genes:M:MDH1|MDH1]]|3.64|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|0.082|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|0.075|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|0.075|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|0.058|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp359|FK-506 30μM R07 exp359]]|0.058|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|0.055|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|0.055|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|0.054|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp274|Citral 50μM R06 exp274]]|0.052|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|0.051|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|0.073|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|0.065|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|0.065|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|0.061|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.055|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp453|B02 10μM R08 exp453]]|0.053|<button type="primary" size="small" modal="16">View</button>|
</modal>


<modal id="1" size="lg" title="CB-839 10μM R05 exp224  vs  EPZ-5676 30μM R05 exp233">
{{:chemogenomics:comparison_plots:exp224_vs_exp233.png?nolink |}}
</modal>

<modal id="2" size="lg" title="CB-839 10μM R05 exp224  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp224_vs_exp344.png?nolink |}}
</modal>

<modal id="3" size="lg" title="CB-839 10μM R05 exp224  vs  WYE-354 6μM R02 exp90">
{{:chemogenomics:comparison_plots:exp224_vs_exp90.png?nolink |}}
</modal>

<modal id="4" size="lg" title="CB-839 10μM R05 exp224  vs  NN-Dimethylsphingosine 2.5μM R08 exp508">
{{:chemogenomics:comparison_plots:exp224_vs_exp508.png?nolink |}}
</modal>

<modal id="5" size="lg" title="CB-839 10μM R05 exp224  vs  FK-506 30μM R07 exp359">
{{:chemogenomics:comparison_plots:exp224_vs_exp359.png?nolink |}}
</modal>

<modal id="6" size="lg" title="CB-839 10μM R05 exp224  vs  NN-Diethyl-meta-toluamide 500μM R08 exp438">
{{:chemogenomics:comparison_plots:exp224_vs_exp438.png?nolink |}}
</modal>

<modal id="7" size="lg" title="CB-839 10μM R05 exp224  vs  Ibrutinib 10μM R08 exp442">
{{:chemogenomics:comparison_plots:exp224_vs_exp442.png?nolink |}}
</modal>

<modal id="8" size="lg" title="CB-839 10μM R05 exp224  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp224_vs_exp530.png?nolink |}}
</modal>

<modal id="9" size="lg" title="CB-839 10μM R05 exp224  vs  Citral 50μM R06 exp274">
{{:chemogenomics:comparison_plots:exp224_vs_exp274.png?nolink |}}
</modal>

<modal id="10" size="lg" title="CB-839 10μM R05 exp224  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp224_vs_exp445.png?nolink |}}
</modal>

<modal id="11" size="lg" title="CAY10603 0.55μM R08 exp467  vs  CB-839 10μM R05 exp224">
{{:chemogenomics:comparison_plots:exp224_vs_exp467.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Azithromycin 100μM R08 exp452  vs  CB-839 10μM R05 exp224">
{{:chemogenomics:comparison_plots:exp224_vs_exp452.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Bisphenol A 100μM R06 exp269  vs  CB-839 10μM R05 exp224">
{{:chemogenomics:comparison_plots:exp224_vs_exp269.png?nolink |}}
</modal>

<modal id="14" size="lg" title="BVD-523 15μM R02 exp67  vs  CB-839 10μM R05 exp224">
{{:chemogenomics:comparison_plots:exp224_vs_exp67.png?nolink |}}
</modal>

<modal id="15" size="lg" title="BS-181 20μM R08 exp461  vs  CB-839 10μM R05 exp224">
{{:chemogenomics:comparison_plots:exp224_vs_exp461.png?nolink |}}
</modal>

<modal id="16" size="lg" title="B02 10μM R08 exp453  vs  CB-839 10μM R05 exp224">
{{:chemogenomics:comparison_plots:exp224_vs_exp453.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>