====== Radicicol 0.16μM R05 exp242 ======
==== Mechanism of Action ====
Inhibits HSP90
  * **<color #00a2e8>Class / Subclass 1:</color>** Proteostasis / Chaperone Inhibitor
  * **<color #00a2e8>Class / Subclass 2:</color>** Infectious Disease / Antifungal



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Radicicol%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 12772-57-5
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/6323491|6323491]]
    * **<color #00a2e8>IUPAC:</color>** %%(4R,6R,8R,9Z,11E)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.06,8]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1
    * **<color #00a2e8>INCHI Key:</color>** WYZWZEOGROVVHK-GTMNPGAYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 364.8
    * **<color #00a2e8>Canonical SMILES:</color>** CC1CC2C(O2)C=CC=CC(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1
    * **<color #00a2e8>Isomeric SMILES:</color>** C[C@@H]1C[C@@H]2[C@H](O2)/C=C\\C=C\\C(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1
    * **<color #00a2e8>Molecular Formula:</color>** C18H17ClO6
{{:chemogenomics:structures:chem-0147.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Cayman Chemical
    * **<color #00a2e8>Catalog #:</color>** 13089
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M-H)- Calcd for C18H17ClO6 363.06409; found 363.06538
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Radicicol
    * **<color #00a2e8>Min:</color>** -1.3077; **<color #00a2e8>Max:</color>** 99.5418
{{:chemogenomics:dose_response:dr_272.png?nolink&500 |}}
\\ 
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |0.0804    |
| IC30  |0.1576    |
| IC40  |0.2736    |
| IC50  |0.4541    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 05
    * **<color #00a2e8>Dose</color>**: 160nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 4.9
    * **<color #00a2e8>Numbers of reads</color>**: 24989585


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|19/4|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Radicicol_0.16uM_Round-5_exp242.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Radicicol 0.16μM R05 exp242'>
{{:chemogenomics:cranks_plots:exp242.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:N:NUDCD1|NUDCD1]]|-3.71|<0.01|
|[[:human_genes:T:TCF4|TCF4]]|-3.33|<0.01|
|[[:human_genes:R:RHOA|RHOA]]|-3.10|<0.01|
|[[:human_genes:S:SLC5A3|SLC5A3]]|-3.00|<0.01|
|[[:human_genes:T:TUBG1|TUBG1]]|-2.99|0.01|
|[[:human_genes:U:UXS1|UXS1]]|-2.96|<0.01|
|[[:human_genes:L:LEF1|LEF1]]|-2.86|<0.01|
|[[:human_genes:A:ANAPC15|ANAPC15]]|-2.77|0.02|
|[[:human_genes:E:ELAVL1|ELAVL1]]|-2.74|<0.01|
|[[:human_genes:L:LMO2|LMO2]]|-2.74|<0.01|
|[[:human_genes:T:TRIM54|TRIM54]]|-2.73|<0.01|
|[[:human_genes:P:PRPS1|PRPS1]]|-2.72|<0.01|
|[[:human_genes:P:PTEN|PTEN]]|-2.71|0.01|
|[[:human_genes:K:KPTN|KPTN]]|-2.57|0.02|
|[[:human_genes:K:KEAP1|KEAP1]]|-2.55|0.04|
|[[:human_genes:H:HSP90AB1|HSP90AB1]]|-2.53|0.05|
|[[:human_genes:F:FBXO38|FBXO38]]|-2.53|0.02|
|[[:human_genes:C:CSK|CSK]]|-2.51|0.09|
|[[:human_genes:S:STK11|STK11]]|-2.41|0.07|
|[[:human_genes:G:GMPPB|GMPPB]]|-2.38|0.16|
|[[:human_genes:S:SZT2|SZT2]]|-2.37|0.05|
|[[:human_genes:I:IRF4|IRF4]]|-2.36|0.05|
|[[:human_genes:L:LDB1|LDB1]]|-2.33|0.05|
|[[:human_genes:S:SEPHS1|SEPHS1]]|-2.30|0.09|
|[[:human_genes:S:SOX4|SOX4]]|-2.26|0.15|
|[[:human_genes:S:SNX32|SNX32]]|-2.23|0.08|
|[[:human_genes:U:UMPS|UMPS]]|-2.22|0.52|
|[[:human_genes:H:HSPA4|HSPA4]]|-2.21|0.12|
|[[:human_genes:P:PRKCE|PRKCE]]|-2.21|0.09|
|[[:human_genes:C:CLTB|CLTB]]|-2.20|0.09|
|[[:human_genes:G:GMEB2|GMEB2]]|2.00|0.32|
|[[:human_genes:E:EIF4G2|EIF4G2]]|2.00|0.32|
|[[:human_genes:U:UBE2H|UBE2H]]|2.00|0.32|
|[[:human_genes:M:MIOS|MIOS]]|2.02|0.32|
|[[:human_genes:H:HDAC5|HDAC5]]|2.04|0.32|
|[[:human_genes:C:COPB1|COPB1]]|2.04|0.50|
|[[:human_genes:F:FA2H|FA2H]]|2.04|0.32|
|[[:human_genes:T:TAZ|TAZ]]|2.08|0.49|
|[[:human_genes:C:CNBP|CNBP]]|2.09|0.28|
|[[:human_genes:T:TIMM8A|TIMM8A]]|2.11|0.32|
|[[:human_genes:D:DHODH|DHODH]]|2.15|0.41|
|[[:human_genes:R:RFC1|RFC1]]|2.17|0.46|
|[[:human_genes:P:PES1|PES1]]|2.19|0.51|
|[[:human_genes:G:GPIHBP1|GPIHBP1]]|2.21|0.28|
|[[:human_genes:P:PPP3CA|PPP3CA]]|2.23|0.18|
|[[:human_genes:P:PHF20|PHF20]]|2.24|0.28|
|[[:human_genes:C:CLN8|CLN8]]|2.27|0.17|
|[[:human_genes:N:NR2C2AP|NR2C2AP]]|2.28|0.32|
|[[:human_genes:T:TCEAL7|TCEAL7]]|2.37|0.13|
|[[:human_genes:C:CMIP|CMIP]]|2.37|0.18|
|[[:human_genes:G:GPR137C|GPR137C]]|2.42|0.17|
|[[:human_genes:C:CDK2|CDK2]]|2.51|0.06|
|[[:human_genes:P:PRPF6|PRPF6]]|2.57|0.41|
|[[:human_genes:H:HK2|HK2]]|2.64|0.24|
|[[:human_genes:E:EIF3A|EIF3A]]|2.74|0.05|
|[[:human_genes:W:WDR5|WDR5]]|2.80|0.28|
|[[:human_genes:D:DGKD|DGKD]]|2.96|<0.01|
|[[:human_genes:S:STRAP|STRAP]]|3.07|<0.01|
|[[:human_genes:E:EIF3G|EIF3G]]|3.19|0.02|
|[[:human_genes:E:EIF4A1|EIF4A1]]|6.11|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|0.055|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|0.055|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|0.079|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|0.075|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|0.071|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|0.067|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.057|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|0.054|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.054|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|0.053|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|0.051|<button type="primary" size="small" modal="11">View</button>|
</modal>


<modal id="1" size="lg" title="Radicicol 0.16μM R05 exp242  vs  Rapamycin 2μM plus FK-506 5μM R07 exp308">
{{:chemogenomics:comparison_plots:exp242_vs_exp308.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Radicicol 0.16μM R05 exp242  vs  Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307">
{{:chemogenomics:comparison_plots:exp242_vs_exp307.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Erlotinib 10μM R05 exp216  vs  Radicicol 0.16μM R05 exp242">
{{:chemogenomics:comparison_plots:exp216_vs_exp242.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  Radicicol 0.16μM R05 exp242">
{{:chemogenomics:comparison_plots:exp242_vs_exp498.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Geldanamycin 0.015 to 0.05μM on day4 R07 exp317  vs  Radicicol 0.16μM R05 exp242">
{{:chemogenomics:comparison_plots:exp242_vs_exp317.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Lead acetate 2000μM R08 exp497  vs  Radicicol 0.16μM R05 exp242">
{{:chemogenomics:comparison_plots:exp242_vs_exp497.png?nolink |}}
</modal>

<modal id="7" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6  vs  Radicicol 0.16μM R05 exp242">
{{:chemogenomics:comparison_plots:exp242_vs_exp500.png?nolink |}}
</modal>

<modal id="8" size="lg" title="LY2090314 0.003μM R08 exp499  vs  Radicicol 0.16μM R05 exp242">
{{:chemogenomics:comparison_plots:exp242_vs_exp499.png?nolink |}}
</modal>

<modal id="9" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Radicicol 0.16μM R05 exp242">
{{:chemogenomics:comparison_plots:exp242_vs_exp468.png?nolink |}}
</modal>

<modal id="10" size="lg" title="EPZ-5676 30μM R05 exp233  vs  Radicicol 0.16μM R05 exp242">
{{:chemogenomics:comparison_plots:exp233_vs_exp242.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Phorbol-12-myristate-13-acetate 0.57μM R08 exp514  vs  Radicicol 0.16μM R05 exp242">
{{:chemogenomics:comparison_plots:exp242_vs_exp514.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|beta-catenin-TCF complex|147.95|TCF4,LEF1,LDB1|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|translation initiation factor activity|47.01|EIF4A1,EIF3G,EIF3A,EIF4G2|
|translational initiation|35.07|EIF4A1,EIF3G,EIF3A,EIF4G2|
|translation regulator activity|20.92|EIF4A1,EIF3G,EIF3A,CNBP,EIF4G2|
</modal>