====== Arsenate 40μM R06 exp264 ======
==== Mechanism of Action ====
Heavy metal toxin, environmental contaminant
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Heavy Metal




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Sodium arsenate heptahydrate%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 10048-95-0
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/61460|61460]]
    * **<color #00a2e8>IUPAC:</color>** %%disodium;hydrogen arsorate;heptahydrate%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/AsH3O4.2Na.7H2O/c2-1(3,4)5;;;;;;;;;/h(H3,2,3,4,5);;;7*1H2/q;2*+1;;;;;;;/p-2
    * **<color #00a2e8>INCHI Key:</color>** KOLXPEJIBITWIQ-UHFFFAOYSA-L
    * **<color #00a2e8>Molecular Weight:</color>** 312.01
    * **<color #00a2e8>Canonical SMILES:</color>** O.O.O.O.O.O.O.O[As](=O)([O-])[O-].[Na+].[Na+]
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** Na2HAsO4. 7H2O
{{:chemogenomics:structures:chem-0158.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Matheson Coleman and Bell
    * **<color #00a2e8>Catalog #:</color>** CR 688
    * **<color #00a2e8>Lot #:</color>** SX 290
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>XRPD:</color>** Expected Na2HAsO4 7H2O; found Na2HAsO4 5H2O
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Sodium_Arsenic
    * **<color #00a2e8>Min:</color>** -15.5442; **<color #00a2e8>Max:</color>** 98.7975
{{:chemogenomics:dose_response:dr_311.png?nolink&500 |}}
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |0.0596    |
| IC30  |0.0640    |
| IC40  |0.0679    |
| IC50  |0.0717    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 06
    * **<color #00a2e8>Dose</color>**: 40µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 3.1
    * **<color #00a2e8>Numbers of reads</color>**: 30321040


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|26/153|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Arsenate_40uM_Round-6_exp264.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Arsenate 40μM R06 exp264'>
{{:chemogenomics:cranks_plots:exp264.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:A:ABCC1|ABCC1]]|-3.98|<0.01|
|[[:human_genes:N:NUDT11|NUDT11]]|-3.87|<0.01|
|[[:human_genes:G:GCLM|GCLM]]|-3.29|<0.01|
|[[:human_genes:Z:ZNF296|ZNF296]]|-3.12|<0.01|
|[[:human_genes:N:NSFL1C|NSFL1C]]|-3.06|<0.01|
|[[:human_genes:T:TSC1|TSC1]]|-3.00|<0.01|
|[[:human_genes:H:HNRNPD|HNRNPD]]|-2.83|<0.01|
|[[:human_genes:P:PSME3|PSME3]]|-2.80|<0.01|
|[[:human_genes:T:TUBG1|TUBG1]]|-2.79|0.03|
|[[:human_genes:P:PPIP5K2|PPIP5K2]]|-2.78|<0.01|
|[[:human_genes:X:XRCC5|XRCC5]]|-2.77|0.03|
|[[:human_genes:R:RTFDC1|RTFDC1]]|-2.76|<0.01|
|[[:human_genes:T:TCF4|TCF4]]|-2.71|<0.01|
|[[:human_genes:P:PHACTR4|PHACTR4]]|-2.70|<0.01|
|[[:human_genes:C:CCNL2|CCNL2]]|-2.69|0.02|
|[[:human_genes:L:LCMT1|LCMT1]]|-2.68|<0.01|
|[[:human_genes:S:SLC7A11|SLC7A11]]|-2.63|0.01|
|[[:human_genes:F:FEM1B|FEM1B]]|-2.61|0.01|
|[[:human_genes:A:ANAPC15|ANAPC15]]|-2.60|0.03|
|[[:human_genes:G:GCLC|GCLC]]|-2.55|0.02|
|[[:human_genes:H:HDAC3|HDAC3]]|-2.54|0.03|
|[[:human_genes:W:WAPAL|WAPAL]]|-2.50|0.07|
|[[:human_genes:T:TSC2|TSC2]]|-2.48|0.02|
|[[:human_genes:S:SART3|SART3]]|-2.47|0.25|
|[[:human_genes:N:NUDT10|NUDT10]]|-2.45|0.03|
|[[:human_genes:C:CUL1|CUL1]]|-2.43|0.05|
|[[:human_genes:S:SART1|SART1]]|-2.40|0.27|
|[[:human_genes:R:RGL2|RGL2]]|-2.39|0.03|
|[[:human_genes:N:NGLY1|NGLY1]]|-2.38|0.03|
|[[:human_genes:V:VPS25|VPS25]]|-2.37|0.38|
|[[:human_genes:S:SRSF5|SRSF5]]|3.74|0.00|
|[[:human_genes:M:MAGT1|MAGT1]]|3.79|0.00|
|[[:human_genes:G:GPI|GPI]]|3.84|0.00|
|[[:human_genes:S:SRM|SRM]]|3.89|0.00|
|[[:human_genes:C:C9orf41|C9orf41]]|3.90|0.00|
|[[:human_genes:A:AHCYL1|AHCYL1]]|4.01|0.00|
|[[:human_genes:S:STK11|STK11]]|4.07|0.00|
|[[:human_genes:C:CNBP|CNBP]]|4.10|0.00|
|[[:human_genes:E:EIF3H|EIF3H]]|4.14|0.00|
|[[:human_genes:P:PRKAB1|PRKAB1]]|4.19|0.00|
|[[:human_genes:P:PGGT1B|PGGT1B]]|4.26|0.00|
|[[:human_genes:N:NCLN|NCLN]]|4.38|0.00|
|[[:human_genes:T:TMEM147|TMEM147]]|4.70|0.00|
|[[:human_genes:R:RIC8A|RIC8A]]|4.84|0.00|
|[[:human_genes:I:IPMK|IPMK]]|4.89|0.00|
|[[:human_genes:G:GNA13|GNA13]]|5.15|0.00|
|[[:human_genes:R:RHOA|RHOA]]|5.45|0.00|
|[[:human_genes:L:LIN7C|LIN7C]]|5.55|0.00|
|[[:human_genes:T:TMEM208|TMEM208]]|5.64|0.00|
|[[:human_genes:I:IP6K1|IP6K1]]|5.78|0.00|
|[[:human_genes:E:EPB41L2|EPB41L2]]|5.86|0.00|
|[[:human_genes:P:PRKAG1|PRKAG1]]|6.01|0.00|
|[[:human_genes:S:STRADA|STRADA]]|6.37|0.00|
|[[:human_genes:I:IP6K2|IP6K2]]|6.42|0.00|
|[[:human_genes:P:PRKAA1|PRKAA1]]|7.41|0.00|
|[[:human_genes:M:MPP6|MPP6]]|7.75|0.00|
|[[:human_genes:K:KIDINS220|KIDINS220]]|7.91|0.00|
|[[:human_genes:S:SLC20A1|SLC20A1]]|8.34|0.00|
|[[:human_genes:I:IPPK|IPPK]]|8.43|0.00|
|[[:human_genes:X:XPR1|XPR1]]|8.46|0.00|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.086|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.08|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.07|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.066|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.064|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.063|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|0.058|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|0.057|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|0.057|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|0.054|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|0.053|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.052|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.052|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|0.051|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|0.051|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.053|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.052|<button type="primary" size="small" modal="17">View</button>|
</modal>


<modal id="1" size="lg" title="Arsenate 40μM R06 exp264  vs  Thimerosal 0.85μM R08 exp529">
{{:chemogenomics:comparison_plots:exp264_vs_exp529.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Arsenate 40μM R06 exp264  vs  Hippuristanol 0.12μM R08 exp488">
{{:chemogenomics:comparison_plots:exp264_vs_exp488.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Arsenate 40μM R06 exp264  vs  Hippuristanol 0.12μM R08 exp489 no dilution day6">
{{:chemogenomics:comparison_plots:exp264_vs_exp489.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Arsenate 40μM R06 exp264  vs  MLN-4924 0.2μM R00 exp21">
{{:chemogenomics:comparison_plots:exp21_vs_exp264.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Arsenate 40μM R06 exp264  vs  Sulforaphane 9μM R08 exp525">
{{:chemogenomics:comparison_plots:exp264_vs_exp525.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Arsenate 40μM R06 exp264  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp264_vs_exp485.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Arsenate 40μM R06 exp264  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp264_vs_exp526.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Arsenate 40μM R06 exp264  vs  VER-155008 3.9μM R06 exp301">
{{:chemogenomics:comparison_plots:exp264_vs_exp301.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Arsenate 40μM R06 exp264  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp264_vs_exp84.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Arsenate 40μM R06 exp264  vs  Milciclib 2μM R08 exp502">
{{:chemogenomics:comparison_plots:exp264_vs_exp502.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Arsenate 40μM R06 exp264  vs  Trimetrexate 0.03μM R08 exp535">
{{:chemogenomics:comparison_plots:exp264_vs_exp535.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Arsenate 40μM R06 exp264  vs  MS023 2μM R03 exp134">
{{:chemogenomics:comparison_plots:exp134_vs_exp264.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Arsenate 40μM R06 exp264  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp264_vs_exp468.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Arsenate 40μM R06 exp264  vs  LLY-283 2.6μM R06 exp290">
{{:chemogenomics:comparison_plots:exp264_vs_exp290.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Arsenate 40μM R06 exp264  vs  Nutlin-3A 1.6μM R06 exp294">
{{:chemogenomics:comparison_plots:exp264_vs_exp294.png?nolink |}}
</modal>

<modal id="16" size="lg" title="AICAR 240μM R03 exp116  vs  Arsenate 40μM R06 exp264">
{{:chemogenomics:comparison_plots:exp116_vs_exp264.png?nolink |}}
</modal>

<modal id="17" size="lg" title="AICAR 240μM R05 exp211  vs  Arsenate 40μM R06 exp264">
{{:chemogenomics:comparison_plots:exp211_vs_exp264.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|adenosine 5-(hexahydrogen pentaphosphate) catabolic process|381.03|NUDT11,NUDT10|
|diphosphoinositol-polyphosphate diphosphatase activity|381.03|NUDT11,NUDT10|
|diadenosine hexaphosphate metabolic process|381.03|NUDT11,NUDT10|
|diadenosine hexaphosphate catabolic process|285.78|NUDT11,NUDT10|
|diadenosine polyphosphate catabolic process|285.78|NUDT11,NUDT10|
|response to human chorionic gonadotropin|285.78|GCLM,GCLC|
|response to L-phenylalanine derivative|228.62|GCLM,GCLC|
|inositol phosphate metabolic process|61.24|NUDT11,PPIP5K2,NUDT10|
|mitotic cell cycle process|7.72|NSFL1C,TUBG1,RTF2,LCMT1,HDAC3,WAPL,CUL1|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|inositol 5-diphosphate pentakisphosphate 5-kinase activity|552.50|IP6K2,IP6K1|
|inositol heptakisphosphate kinase activity|276.25|IP6K2,IP6K1|
|cAMP-dependent protein kinase activity|221.00|PRKAA1,PRKAG1|
|inositol phosphate biosynthetic process|138.12|IPPK,IP6K2,IPMK|
|inositol phosphate metabolic process|78.93|IPPK,IP6K2,IP6K1,IPMK|
|polyol biosynthetic process|50.23|IPPK,IP6K2,IP6K1,IPMK|
|alcohol biosynthetic process|30.69|IPPK,PRKAA1,IP6K2,IP6K1,IPMK|
|polyol metabolic process|24.56|IPPK,IP6K2,IP6K1,IPMK|
|protein kinase complex|19.05|PRKAA1,STRADA,PRKAG1,PRKAB1,STK11|
|organic hydroxy compound biosynthetic process|16.54|IPPK,PRKAA1,IP6K2,IP6K1,IPMK|
|small molecule biosynthetic process|9.87|IPPK,PRKAA1,IP6K2,PRKAG1,IP6K1,IPMK,PRKAB1,GPI|
|phosphotransferase activity, alcohol group as acceptor|7.34|IPPK,PRKAA1,IP6K2,STRADA,PRKAG1,IP6K1,IPMK,PRKAB1,STK11|
|phosphorylation|6.89|IPPK,PRKAA1,IP6K2,STRADA,PRKAG1,IP6K1,IPMK,PRKAB1,STK11|
|kinase activity|6.81|IPPK,PRKAA1,IP6K2,STRADA,PRKAG1,IP6K1,IPMK,PRKAB1,STK11|
|transferase activity, transferring phosphorus-containing groups|5.59|IPPK,PRKAA1,IP6K2,STRADA,PRKAG1,IP6K1,IPMK,PRKAB1,STK11|
</modal>