====== Pimelic-diphenylamide-106 5μM R00 exp28 ======
==== Mechanism of Action ====
Inhibits HDAC3 selectively, benzamide derivative
  * **<color #00a2e8>Class / Subclass 1:</color>** Gene Regulation / Epigenetic Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Pimelic Diphenylamide 106%%
    * **<color #00a2e8>Synonyms:</color>** RGFA-8; TC-H 106; Histone Deacetylase Inhibitor VII; RGFA-8;TC-H 106;Histone Deacetylase Inhibitor VII
    * **<color #00a2e8>CAS #:</color>** 937039-45-7
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/16070100|16070100]]
    * **<color #00a2e8>IUPAC:</color>** %%N'-(2-aminophenyl)-N-(4-methylphenyl)heptanediamide%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C20H25N3O2/c1-15-11-13-16(14-12-15)22-19(24)9-3-2-4-10-20(25)23-18-8-6-5-7-17(18)21/h5-8,11-14H,2-4,9-10,21H2,1H3,(H,22,24)(H,23,25)
    * **<color #00a2e8>INCHI Key:</color>** WTKBRPXPNAKVEQ-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 339.4
    * **<color #00a2e8>Canonical SMILES:</color>** CC1=CC=C(C=C1)NC(=O)CCCCCC(=O)NC2=CC=CC=C2N
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C20H25N3O2
{{:chemogenomics:structures:chem-0015.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** SML0313
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C20H25N3O2 340.20195; found 340.20313
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** PD106
    * **<color #00a2e8>Min:</color>** -5.1320; **<color #00a2e8>Max:</color>** 91.7728
{{:chemogenomics:dose_response:dr_106.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |0.7702    |
| IC30  |1.0245    |
| IC40  |1.2946    |
| IC50  |1.6046    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 00
    * **<color #00a2e8>Dose</color>**: 5µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 0.9
    * **<color #00a2e8>Numbers of reads</color>**: 10544665


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|21/33|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Pimelic_Diphenylamide_106_5uM_Round-0_exp28.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Pimelic-diphenylamide-106 5μM R00 exp28'>
{{:chemogenomics:cranks_plots:exp28.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:B:BRD2|BRD2]]|-3.61|<0.01|
|[[:human_genes:P:PDS5B|PDS5B]]|-3.31|<0.01|
|[[:human_genes:N:NOL9|NOL9]]|-3.28|0.02|
|[[:human_genes:T:TSC2|TSC2]]|-3.26|<0.01|
|[[:human_genes:X:XAB2|XAB2]]|-3.20|0.04|
|[[:human_genes:C:COX7A2L|COX7A2L]]|-3.10|<0.01|
|[[:human_genes:A:ARID4B|ARID4B]]|-2.96|0.01|
|[[:human_genes:A:ATP6V1B2|ATP6V1B2]]|-2.92|0.01|
|[[:human_genes:N:NOM1|NOM1]]|-2.91|0.01|
|[[:human_genes:N:NPRL3|NPRL3]]|-2.82|0.03|
|[[:human_genes:A:ADIPOR2|ADIPOR2]]|-2.81|0.01|
|[[:human_genes:E:EP300|EP300]]|-2.76|0.13|
|[[:human_genes:C:CLN8|CLN8]]|-2.74|0.02|
|[[:human_genes:M:MVK|MVK]]|-2.68|0.03|
|[[:human_genes:E:EXOSC7|EXOSC7]]|-2.65|0.05|
|[[:human_genes:P:POLA1|POLA1]]|-2.63|0.36|
|[[:human_genes:O:OSBP|OSBP]]|-2.62|0.17|
|[[:human_genes:S:SEPHS2|SEPHS2]]|-2.61|0.02|
|[[:human_genes:S:SPI1|SPI1]]|-2.58|0.04|
|[[:human_genes:C:COPB2|COPB2]]|-2.58|0.12|
|[[:human_genes:G:GOLGA6L1|GOLGA6L1]]|-2.56|0.26|
|[[:human_genes:V:VPS25|VPS25]]|-2.56|0.18|
|[[:human_genes:L:LPAR5|LPAR5]]|-2.51|0.03|
|[[:human_genes:H:HEXIM1|HEXIM1]]|-2.48|0.03|
|[[:human_genes:M:MBD1|MBD1]]|-2.45|0.03|
|[[:human_genes:A:ATP6V0B|ATP6V0B]]|-2.45|0.11|
|[[:human_genes:M:MRFAP1L1|MRFAP1L1]]|-2.40|0.04|
|[[:human_genes:N:NPAS1|NPAS1]]|-2.38|0.04|
|[[:human_genes:U:UPF1|UPF1]]|-2.38|0.24|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.33|0.10|
|[[:human_genes:C:CCT7|CCT7]]|2.43|0.02|
|[[:human_genes:P:PRC1|PRC1]]|2.44|0.02|
|[[:human_genes:O:OPA1|OPA1]]|2.48|0.02|
|[[:human_genes:H:HSPD1|HSPD1]]|2.48|0.02|
|[[:human_genes:Y:YARS|YARS]]|2.54|0.08|
|[[:human_genes:G:GFPT1|GFPT1]]|2.56|0.02|
|[[:human_genes:C:CARS|CARS]]|2.57|0.07|
|[[:human_genes:T:TIMM23B|TIMM23B]]|2.62|0.11|
|[[:human_genes:O:OTUD5|OTUD5]]|2.63|0.02|
|[[:human_genes:N:NDUFA1|NDUFA1]]|2.63|0.02|
|[[:human_genes:B:BEND3|BEND3]]|2.64|<0.01|
|[[:human_genes:A:ADIPOR1|ADIPOR1]]|2.82|<0.01|
|[[:human_genes:S:SERF2|SERF2]]|2.83|0.02|
|[[:human_genes:R:RPTOR|RPTOR]]|2.83|<0.01|
|[[:human_genes:C:CSNK2B|CSNK2B]]|2.84|<0.01|
|[[:human_genes:A:ATP5J|ATP5J]]|2.96|<0.01|
|[[:human_genes:U:UBE2K|UBE2K]]|2.99|<0.01|
|[[:human_genes:P:PLAA|PLAA]]|3.38|<0.01|
|[[:human_genes:D:DIABLO|DIABLO]]|3.70|<0.01|
|[[:human_genes:F:FAF2|FAF2]]|3.71|<0.01|
|[[:human_genes:H:HDAC2|HDAC2]]|3.80|<0.01|
|[[:human_genes:C:CASP9|CASP9]]|3.97|<0.01|
|[[:human_genes:U:UBQLN1|UBQLN1]]|4.23|<0.01|
|[[:human_genes:M:MEAF6|MEAF6]]|4.68|<0.01|
|[[:human_genes:V:VDAC2|VDAC2]]|4.91|<0.01|
|[[:human_genes:H:HCCS|HCCS]]|5.00|<0.01|
|[[:human_genes:C:CYCS|CYCS]]|5.02|<0.01|
|[[:human_genes:A:APAF1|APAF1]]|5.81|<0.01|
|[[:human_genes:M:MARCH5|MARCH5]]|6.96|<0.01|
|[[:human_genes:B:BAK1|BAK1]]|7.17|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|0.151|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.124|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.108|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.107|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.079|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.07|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.067|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|0.06|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.058|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.199|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.198|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.148|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.126|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|0.126|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.121|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.116|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp17|DABN 20μM R00 exp17]]|0.113|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.111|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.109|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|0.102|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.092|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp135|MS023 7μM R03 exp135]]|0.081|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.081|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.08|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.08|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.078|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.077|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp539|42°C R08 exp539]]|0.077|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.076|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.071|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.069|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.068|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.068|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|0.064|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.062|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|0.062|<button type="primary" size="small" modal="36">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.061|<button type="primary" size="small" modal="37">View</button>|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.061|<button type="primary" size="small" modal="38">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.057|<button type="primary" size="small" modal="39">View</button>|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|0.057|<button type="primary" size="small" modal="40">View</button>|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|0.054|<button type="primary" size="small" modal="41">View</button>|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|0.054|<button type="primary" size="small" modal="42">View</button>|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|0.053|<button type="primary" size="small" modal="43">View</button>|
</modal>


<modal id="1" size="lg" title="Pimelic-diphenylamide-106 5μM R00 exp28  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp28_vs_exp34.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Pimelic-diphenylamide-106 5μM R00 exp28  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp28_vs_exp531.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Pimelic-diphenylamide-106 5μM R00 exp28  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp28_vs_exp527.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Pimelic-diphenylamide-106 5μM R00 exp28  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp28_vs_exp80.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Pimelic-diphenylamide-106 5μM R00 exp28  vs  Staurosporine 0.02μM R08 exp524">
{{:chemogenomics:comparison_plots:exp28_vs_exp524.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Pimelic-diphenylamide-106 5μM R00 exp28  vs  UM131593 0.2μM R03 exp106">
{{:chemogenomics:comparison_plots:exp106_vs_exp28.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Pimelic-diphenylamide-106 5μM R00 exp28  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp28_vs_exp443.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Pimelic-diphenylamide-106 5μM R00 exp28  vs  Rotenone 2μM R00 exp33">
{{:chemogenomics:comparison_plots:exp28_vs_exp33.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Pimelic-diphenylamide-106 5μM R00 exp28  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp28_vs_exp85.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Etoposide 1μM R00 exp19  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp19_vs_exp28.png?nolink |}}
</modal>

<modal id="11" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp2_vs_exp28.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp3.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp199_vs_exp28.png?nolink |}}
</modal>

<modal id="14" size="lg" title="MLN-4924 2μM R00 exp22  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp22_vs_exp28.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Bleomycin 5μM R08 exp459  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp459.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp503.png?nolink |}}
</modal>

<modal id="17" size="lg" title="DABN 20μM R00 exp17  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp17_vs_exp28.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Benzoate 20000μM R08 exp456  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp456.png?nolink |}}
</modal>

<modal id="19" size="lg" title="CI-1040 9.5μM R08 exp472  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp472.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Bortezomib 0.05μM R00 exp7  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp7.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Doxorubicin 0.02μM R08 exp478  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp478.png?nolink |}}
</modal>

<modal id="22" size="lg" title="MS023 7μM R03 exp135  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp135_vs_exp28.png?nolink |}}
</modal>

<modal id="23" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp440.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Hippuristanol 0.12μM R08 exp489 no dilution day6  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp489.png?nolink |}}
</modal>

<modal id="25" size="lg" title="Hippuristanol 0.12μM R08 exp488  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp488.png?nolink |}}
</modal>

<modal id="26" size="lg" title="Atovaquone 15μM R08 exp451  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp451.png?nolink |}}
</modal>

<modal id="27" size="lg" title="PU-H71 1μM R08 exp515  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp515.png?nolink |}}
</modal>

<modal id="28" size="lg" title="42°C R08 exp539  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp539.png?nolink |}}
</modal>

<modal id="29" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp259_vs_exp28.png?nolink |}}
</modal>

<modal id="30" size="lg" title="Dorsomorphin 5μM R07 exp357  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp357.png?nolink |}}
</modal>

<modal id="31" size="lg" title="Olaparib 4μM R08 exp512  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp512.png?nolink |}}
</modal>

<modal id="32" size="lg" title="GSK626616 14μM R08 exp485  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp485.png?nolink |}}
</modal>

<modal id="33" size="lg" title="JQ1 0.8μM R08 exp435  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp435.png?nolink |}}
</modal>

<modal id="34" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp355.png?nolink |}}
</modal>

<modal id="35" size="lg" title="GSK461364A 0.1μM R03 exp126  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp126_vs_exp28.png?nolink |}}
</modal>

<modal id="36" size="lg" title="Oligomycin-A 20μM R00 exp26  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp26_vs_exp28.png?nolink |}}
</modal>

<modal id="37" size="lg" title="AICAR 240μM R05 exp211  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp211_vs_exp28.png?nolink |}}
</modal>

<modal id="38" size="lg" title="GSK-J4 1.5μM R08 exp441  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp441.png?nolink |}}
</modal>

<modal id="39" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp474.png?nolink |}}
</modal>

<modal id="40" size="lg" title="Actinomycin-D 0.01μM R00 exp4  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp4.png?nolink |}}
</modal>

<modal id="41" size="lg" title="Deferoxamine 11μM R07 exp350  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp350.png?nolink |}}
</modal>

<modal id="42" size="lg" title="BVD-523 15μM R02 exp67  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp67.png?nolink |}}
</modal>

<modal id="43" size="lg" title="Nocodazole 0.2μM R00 exp24  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp24_vs_exp28.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|apoptosome|552.70|APAF1,CASP9|
|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|442.16|APAF1,CYCS,CASP9,DIABLO|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|34.01|APAF1,CYCS,CASP9,HSPD1|
|positive regulation of cysteine-type endopeptidase activity|26.74|BAK1,APAF1,CYCS,CASP9,DIABLO,HSPD1|
|positive regulation of endopeptidase activity|22.87|BAK1,APAF1,CYCS,CASP9,DIABLO,HSPD1|
|positive regulation of peptidase activity|20.86|BAK1,APAF1,CYCS,CASP9,DIABLO,HSPD1|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|17.71|APAF1,CYCS,CASP9,DIABLO,HSPD1|
|regulation of cysteine-type endopeptidase activity|17.64|BAK1,APAF1,CYCS,CASP9,DIABLO,HSPD1|
|intrinsic apoptotic signaling pathway|17.27|BAK1,APAF1,CYCS,CASP9,DIABLO|
|positive regulation of proteolysis|13.16|BAK1,APAF1,CYCS,UBQLN1,CASP9,HDAC2,DIABLO,HSPD1|
|regulation of endopeptidase activity|12.37|BAK1,APAF1,CYCS,CASP9,DIABLO,HSPD1|
|regulation of peptidase activity|11.40|BAK1,APAF1,CYCS,CASP9,DIABLO,HSPD1|
|apoptotic signaling pathway|10.77|BAK1,APAF1,CYCS,VDAC2,CASP9,DIABLO|
|regulation of proteolysis|8.43|BAK1,APAF1,CYCS,UBQLN1,CASP9,HDAC2,DIABLO,UBE2K,HSPD1|
|mitochondrial inner membrane|8.43|CYCS,HCCS,ATP5PF,NDUFA1,TIMM23B,HSPD1,OPA1|
|mitochondrial envelope|8.08|BAK1,MARCHF5,CYCS,HCCS,VDAC2,DIABLO,ATP5PF,NDUFA1,TIMM23B,HSPD1,OPA1|
|positive regulation of hydrolase activity|8.06|BAK1,APAF1,CYCS,CASP9,DIABLO,PLAA,HSPD1|
|mitochondrial membrane|7.83|BAK1,MARCHF5,CYCS,HCCS,VDAC2,ATP5PF,NDUFA1,TIMM23B,HSPD1,OPA1|
|organelle inner membrane|7.57|CYCS,HCCS,ATP5PF,NDUFA1,TIMM23B,HSPD1,OPA1|
</modal>