====== Menadione 5μM R06 exp292 ======
==== Mechanism of Action ====
Synthetic analog of vitamin K, quinone redox cycle generates ROS
  * **<color #00a2e8>Class / Subclass 1:</color>** Metabolism / Nutrient
  * **<color #00a2e8>Class / Subclass 2:</color>** Environmental Stresses / Food Additive



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Menadione%%
    * **<color #00a2e8>Synonyms:</color>** Vitamin K3
    * **<color #00a2e8>CAS #:</color>** 58-27-5
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/4055|4055]]
    * **<color #00a2e8>IUPAC:</color>** %%2-methylnaphthalene-1,4-dione%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
    * **<color #00a2e8>INCHI Key:</color>** MJVAVZPDRWSRRC-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 172.18
    * **<color #00a2e8>Canonical SMILES:</color>** CC1=CC(=O)C2=CC=CC=C2C1=O
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C11H8O2
{{:chemogenomics:structures:chem-0180.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** M5625
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>LCMS:</color>** Tr 1.21 min, m/z invisible, Lamdba max 250, 262, 336 nm
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Menadione
    * **<color #00a2e8>Min:</color>** -21.7794; **<color #00a2e8>Max:</color>** 99.2492
{{:chemogenomics:dose_response:dr_231.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |8.0620    |
| IC30  |8.3166    |
| IC40  |8.5312    |
| IC50  |8.7331    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 06
    * **<color #00a2e8>Dose</color>**: 5µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 5.1
    * **<color #00a2e8>Numbers of reads</color>**: 31446298


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|11/2|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Menadione_5uM_Round-6_exp292.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Menadione 5μM R06 exp292'>
{{:chemogenomics:cranks_plots:exp292.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:A:ABCC1|ABCC1]]|-5.84|<0.01|
|[[:human_genes:S:SLC7A11|SLC7A11]]|-5.18|<0.01|
|[[:human_genes:P:PRDX1|PRDX1]]|-4.21|<0.01|
|[[:human_genes:P:PLEKHA2|PLEKHA2]]|-3.45|0.01|
|[[:human_genes:G:GCLM|GCLM]]|-3.21|<0.01|
|[[:human_genes:U:UVSSA|UVSSA]]|-2.66|0.02|
|[[:human_genes:C:C6orf136|C6orf136]]|-2.61|0.03|
|[[:human_genes:S:SWI5|SWI5]]|-2.56|0.05|
|[[:human_genes:S:SLC3A2|SLC3A2]]|-2.55|0.10|
|[[:human_genes:T:TCF4|TCF4]]|-2.54|0.03|
|[[:human_genes:F:FAM122A|FAM122A]]|-2.51|0.03|
|[[:human_genes:C:CNOT8|CNOT8]]|-2.51|0.03|
|[[:human_genes:S:SEPHS2|SEPHS2]]|-2.46|0.04|
|[[:human_genes:V:VPS25|VPS25]]|-2.42|0.51|
|[[:human_genes:Z:ZBTB7A|ZBTB7A]]|-2.40|0.05|
|[[:human_genes:M:MSI2|MSI2]]|-2.33|0.07|
|[[:human_genes:G:GIMAP7|GIMAP7]]|-2.30|0.08|
|[[:human_genes:N:NFKBIZ|NFKBIZ]]|-2.22|0.11|
|[[:human_genes:L:LCMT1|LCMT1]]|-2.22|0.11|
|[[:human_genes:U:UBE2E1|UBE2E1]]|-2.20|0.12|
|[[:human_genes:U:UBE3D|UBE3D]]|-2.18|0.12|
|[[:human_genes:P:PIGY|PIGY]]|-2.17|0.20|
|[[:human_genes:P:PAX5|PAX5]]|-2.17|0.30|
|[[:human_genes:O:OR5R1|OR5R1]]|-2.16|0.13|
|[[:human_genes:S:SEPHS1|SEPHS1]]|-2.15|0.13|
|[[:human_genes:S:STPG1|STPG1]]|-2.14|0.21|
|[[:human_genes:K:KIDINS220|KIDINS220]]|-2.13|0.14|
|[[:human_genes:P:PLN|PLN]]|-2.09|0.73|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.09|0.35|
|[[:human_genes:G:G6PD|G6PD]]|-2.08|0.18|
|[[:human_genes:D:DPP8|DPP8]]|2.00|0.40|
|[[:human_genes:C:C3orf33|C3orf33]]|2.03|0.38|
|[[:human_genes:N:NUP214|NUP214]]|2.04|0.46|
|[[:human_genes:K:KIAA1211|KIAA1211]]|2.05|0.51|
|[[:human_genes:R:RBM8A|RBM8A]]|2.05|0.42|
|[[:human_genes:S:SYNPR|SYNPR]]|2.05|0.36|
|[[:human_genes:G:GPRASP1|GPRASP1]]|2.06|0.36|
|[[:human_genes:T:TVP23A|TVP23A]]|2.07|0.36|
|[[:human_genes:C:CAPZA3|CAPZA3]]|2.07|0.36|
|[[:human_genes:S:SYCE2|SYCE2]]|2.08|0.40|
|[[:human_genes:S:SLC10A7|SLC10A7]]|2.09|0.36|
|[[:human_genes:D:DGCR14|DGCR14]]|2.09|0.42|
|[[:human_genes:N:NPIPB11|NPIPB11]]|2.13|0.44|
|[[:human_genes:R:ROPN1L|ROPN1L]]|2.16|0.29|
|[[:human_genes:S:SLC22A8|SLC22A8]]|2.17|0.41|
|[[:human_genes:C:CDC45|CDC45]]|2.18|0.48|
|[[:human_genes:P:PIK3CD|PIK3CD]]|2.18|0.28|
|[[:human_genes:Z:ZNF320|ZNF320]]|2.21|0.40|
|[[:human_genes:F:FAM84A|FAM84A]]|2.21|0.27|
|[[:human_genes:R:RPL27A|RPL27A]]|2.21|0.52|
|[[:human_genes:P:PDHX|PDHX]]|2.22|0.27|
|[[:human_genes:P:PSMD3|PSMD3]]|2.24|0.51|
|[[:human_genes:U:UFSP2|UFSP2]]|2.27|0.26|
|[[:human_genes:R:RPL30|RPL30]]|2.31|0.44|
|[[:human_genes:T:TCF7L2|TCF7L2]]|2.36|0.18|
|[[:human_genes:A:APAF1|APAF1]]|2.39|0.18|
|[[:human_genes:M:MFGE8|MFGE8]]|2.57|0.18|
|[[:human_genes:B:BIRC6|BIRC6]]|2.73|0.05|
|[[:human_genes:R:RPL36A-HNRNPH2|RPL36A-HNRNPH2]]|2.76|0.46|
|[[:human_genes:A:ARRDC3|ARRDC3]]|2.81|0.05|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|0.057|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|0.053|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|0.052|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|0.051|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|0.074|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|0.054|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|0.053|<button type="primary" size="small" modal="7">View</button>|
</modal>


<modal id="1" size="lg" title="Menadione 5μM R06 exp292  vs  Vincristine 0.0005μM R04 exp190">
{{:chemogenomics:comparison_plots:exp190_vs_exp292.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Menadione 5μM R06 exp292  vs  Nutlin-3A 1.6μM R06 exp294">
{{:chemogenomics:comparison_plots:exp292_vs_exp294.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Menadione 5μM R06 exp292  vs  YM155 0.001μM R08 exp432">
{{:chemogenomics:comparison_plots:exp292_vs_exp432.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Menadione 5μM R06 exp292  vs  UM0131023 0.05μM R05 exp248">
{{:chemogenomics:comparison_plots:exp248_vs_exp292.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Docosahexaenoic-acid 50μM R07 exp356  vs  Menadione 5μM R06 exp292">
{{:chemogenomics:comparison_plots:exp292_vs_exp356.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Diepoxybutane 3μM R07 exp354  vs  Menadione 5μM R06 exp292">
{{:chemogenomics:comparison_plots:exp292_vs_exp354.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Epigallocatechin gallate 20μM R05 exp230  vs  Menadione 5μM R06 exp292">
{{:chemogenomics:comparison_plots:exp230_vs_exp292.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>