====== All-trans-Retinoic-Acid 40μM R07 exp334 ======
==== Mechanism of Action ====
Ligand for retinoic acid receptor (RAR) and retinoid X receptor (RXR), metabolite of vitamin A1
  * **<color #00a2e8>Class / Subclass 1:</color>** Gene Regulation / Nuclear Receptor Ligand
  * **<color #00a2e8>Class / Subclass 2:</color>** Metabolism / Metabolite



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Tretinoin%%
    * **<color #00a2e8>Synonyms:</color>** ATRA; Tretinoin; Vitamin A acid; all-trans-Retinoic acid; ATRA;Tretinoin;Vitamin A acid;all-trans-Retinoic acid
    * **<color #00a2e8>CAS #:</color>** 302-79-4
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/444795|444795]]
    * **<color #00a2e8>IUPAC:</color>** %%(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
    * **<color #00a2e8>INCHI Key:</color>** SHGAZHPCJJPHSC-YCNIQYBTSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 300.4
    * **<color #00a2e8>Canonical SMILES:</color>** CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
    * **<color #00a2e8>Isomeric SMILES:</color>** CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C
    * **<color #00a2e8>Molecular Formula:</color>** C20H28O2
{{:chemogenomics:structures:chem-0192.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** R2625
    * **<color #00a2e8>Lot #:</color>** SLBB5473V
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C20H28O2 301.21621; found 301.21722
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** ATRA
    * **<color #00a2e8>Min:</color>** 8.9864; **<color #00a2e8>Max:</color>** 98.8174
{{:chemogenomics:dose_response:dr_488.png?nolink&500 |}}
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |0.0445    |
| IC30  |0.8254    |
| IC40  |6.3558    |
| IC50  |36.2335    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 07
    * **<color #00a2e8>Dose</color>**: 40µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 1.8
    * **<color #00a2e8>Numbers of reads</color>**: 23385042


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|6/9|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/All-trans-Retinoic-Acid_40uM_Round-7_exp334.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='All-trans-Retinoic-Acid 40μM R07 exp334'>
{{:chemogenomics:cranks_plots:exp334.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:T:TCF4|TCF4]]|-3.86|<0.01|
|[[:human_genes:D:DERL2|DERL2]]|-3.79|<0.01|
|[[:human_genes:R:RHOA|RHOA]]|-2.81|0.02|
|[[:human_genes:G:GTF3C2|GTF3C2]]|-2.80|0.03|
|[[:human_genes:K:KDSR|KDSR]]|-2.70|0.02|
|[[:human_genes:U:UXS1|UXS1]]|-2.70|0.02|
|[[:human_genes:T:TCF3|TCF3]]|-2.64|0.10|
|[[:human_genes:Z:ZSCAN12|ZSCAN12]]|-2.37|0.45|
|[[:human_genes:A:ARF4|ARF4]]|-2.37|0.10|
|[[:human_genes:C:CBFB|CBFB]]|-2.34|0.10|
|[[:human_genes:P:PRKAA1|PRKAA1]]|-2.33|0.10|
|[[:human_genes:T:TMEM245|TMEM245]]|-2.32|0.30|
|[[:human_genes:G:GTF3C6|GTF3C6]]|-2.31|0.19|
|[[:human_genes:Z:ZBTB10|ZBTB10]]|-2.31|0.10|
|[[:human_genes:K:KIAA1432|KIAA1432]]|-2.25|0.14|
|[[:human_genes:D:DHX37|DHX37]]|-2.19|0.44|
|[[:human_genes:A:ATP6V0A2|ATP6V0A2]]|-2.17|0.30|
|[[:human_genes:R:RPL23|RPL23]]|-2.16|0.67|
|[[:human_genes:N:NPRL3|NPRL3]]|-2.16|0.36|
|[[:human_genes:D:DPAGT1|DPAGT1]]|-2.13|0.23|
|[[:human_genes:D:DUS2|DUS2]]|-2.10|0.26|
|[[:human_genes:L:LEF1|LEF1]]|-2.08|0.28|
|[[:human_genes:A:ABHD5|ABHD5]]|-2.05|0.34|
|[[:human_genes:C:C2orf71|C2orf71]]|-2.04|0.34|
|[[:human_genes:H:HOMEZ|HOMEZ]]|-2.04|0.34|
|[[:human_genes:S:SREK1|SREK1]]|-2.04|0.34|
|[[:human_genes:A:ARL1|ARL1]]|-2.01|0.34|
|[[:human_genes:P:PIGP|PIGP]]|-2.00|0.34|
|[[:human_genes:G:GFPT1|GFPT1]]|-2.00|0.45|
|[[:human_genes:P:PQLC3|PQLC3]]|-1.99|0.34|
|[[:human_genes:I:IRF2|IRF2]]|2.11|0.15|
|[[:human_genes:E:EIF2AK3|EIF2AK3]]|2.13|0.15|
|[[:human_genes:C:CNBP|CNBP]]|2.13|0.15|
|[[:human_genes:K:KIAA0141|KIAA0141]]|2.13|0.15|
|[[:human_genes:L:LRRC30|LRRC30]]|2.18|0.18|
|[[:human_genes:A:AHCYL1|AHCYL1]]|2.19|0.18|
|[[:human_genes:D:DDX46|DDX46]]|2.19|0.64|
|[[:human_genes:B:BSCL2|BSCL2]]|2.23|0.16|
|[[:human_genes:G:GPX4|GPX4]]|2.26|0.09|
|[[:human_genes:T:TAF15|TAF15]]|2.27|0.23|
|[[:human_genes:R:RPRD1B|RPRD1B]]|2.27|0.09|
|[[:human_genes:S:SP2|SP2]]|2.28|0.09|
|[[:human_genes:S:SNRNP70|SNRNP70]]|2.29|0.15|
|[[:human_genes:M:MAPKAP1|MAPKAP1]]|2.32|0.07|
|[[:human_genes:S:SPOP|SPOP]]|2.32|0.07|
|[[:human_genes:P:PIK3CD|PIK3CD]]|2.34|0.07|
|[[:human_genes:E:EIF4B|EIF4B]]|2.35|0.07|
|[[:human_genes:N:NAA50|NAA50]]|2.38|0.09|
|[[:human_genes:M:METTL1|METTL1]]|2.40|0.15|
|[[:human_genes:A:AXIN1|AXIN1]]|2.47|0.07|
|[[:human_genes:C:CD79A|CD79A]]|2.54|0.07|
|[[:human_genes:B:BBX|BBX]]|2.55|0.03|
|[[:human_genes:S:SRM|SRM]]|2.56|0.03|
|[[:human_genes:C:CDV3|CDV3]]|2.59|0.03|
|[[:human_genes:J:JMJD1C|JMJD1C]]|2.63|0.03|
|[[:human_genes:R:RICTOR|RICTOR]]|2.81|0.01|
|[[:human_genes:D:DPH1|DPH1]]|2.85|0.01|
|[[:human_genes:O:OMA1|OMA1]]|3.25|<0.01|
|[[:human_genes:E:EIF4A1|EIF4A1]]|3.47|<0.01|
|[[:human_genes:T:TTC14|TTC14]]|3.49|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|0.07|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp275|Citral 75μM R06 exp275]]|0.069|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|0.069|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.066|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|0.065|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|0.063|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|0.061|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.055|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|0.054|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|0.054|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp504|MK2206 4μM R08 exp504]]|0.052|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|0.051|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.051|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|0.051|<button type="primary" size="small" modal="14">View</button>|
</modal>


<modal id="1" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  Bisphenol A 100μM R06 exp269">
{{:chemogenomics:comparison_plots:exp269_vs_exp334.png?nolink |}}
</modal>

<modal id="2" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  Citral 75μM R06 exp275">
{{:chemogenomics:comparison_plots:exp275_vs_exp334.png?nolink |}}
</modal>

<modal id="3" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  Thapsigargin 0.005μM R07 exp407">
{{:chemogenomics:comparison_plots:exp334_vs_exp407.png?nolink |}}
</modal>

<modal id="4" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  Sulforaphane 9μM R08 exp525">
{{:chemogenomics:comparison_plots:exp334_vs_exp525.png?nolink |}}
</modal>

<modal id="5" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307">
{{:chemogenomics:comparison_plots:exp307_vs_exp334.png?nolink |}}
</modal>

<modal id="6" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  Lead acetate 2000μM R08 exp497">
{{:chemogenomics:comparison_plots:exp334_vs_exp497.png?nolink |}}
</modal>

<modal id="7" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp334_vs_exp526.png?nolink |}}
</modal>

<modal id="8" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp334_vs_exp468.png?nolink |}}
</modal>

<modal id="9" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp334.png?nolink |}}
</modal>

<modal id="10" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  Cannabidiol 20μM R08 exp466">
{{:chemogenomics:comparison_plots:exp334_vs_exp466.png?nolink |}}
</modal>

<modal id="11" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  MK2206 4μM R08 exp504">
{{:chemogenomics:comparison_plots:exp334_vs_exp504.png?nolink |}}
</modal>

<modal id="12" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420">
{{:chemogenomics:comparison_plots:exp334_vs_exp420.png?nolink |}}
</modal>

<modal id="13" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  Ethanol 0.01 R05 exp234">
{{:chemogenomics:comparison_plots:exp234_vs_exp334.png?nolink |}}
</modal>

<modal id="14" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  Lead acetate 2000μM R08 exp498 no dilution day6">
{{:chemogenomics:comparison_plots:exp334_vs_exp498.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>