====== Cyclosporin-A 3μM R07 exp348 ======
==== Mechanism of Action ====
Inhibits calcineurin, forms ternary complex with immunophilin (FBKP) and calcineurin
  * **<color #00a2e8>Class / Subclass 1:</color>** Signal Transduction / Phosphatase Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Cyclosporin A%%
    * **<color #00a2e8>Synonyms:</color>** Cyclosporine; Ciclosporin
    * **<color #00a2e8>CAS #:</color>** 59865-13-3
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/5284373|5284373]]
    * **<color #00a2e8>IUPAC:</color>** %%(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
    * **<color #00a2e8>INCHI Key:</color>** PMATZTZNYRCHOR-CGLBZJNRSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 1202.6
    * **<color #00a2e8>Canonical SMILES:</color>** CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
    * **<color #00a2e8>Isomeric SMILES:</color>** CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
    * **<color #00a2e8>Molecular Formula:</color>** C62H111N11O12
{{:chemogenomics:structures:chem-0205.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** 30024
    * **<color #00a2e8>Lot #:</color>** 142714V
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C62H111N11O12 1202.84864; found 1202.84948
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Cyclosporin_A
    * **<color #00a2e8>Min:</color>** -12.3631; **<color #00a2e8>Max:</color>** 65.5231
{{:chemogenomics:dose_response:dr_378.png?nolink&500 |}}
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |1.3507    |
| IC30  |2.2063    |
| IC40  |3.6911    |
| IC50  |6.9823    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 07
    * **<color #00a2e8>Dose</color>**: 3µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 6.0
    * **<color #00a2e8>Numbers of reads</color>**: 17448463


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|2/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Cyclosporin_A_3uM_Round-7_exp348.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Cyclosporin-A 3μM R07 exp348'>
{{:chemogenomics:cranks_plots:exp348.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:D:DNAJC3|DNAJC3]]|-3.42|<0.01|
|[[:human_genes:I:INPP5K|INPP5K]]|-2.77|0.04|
|[[:human_genes:C:CXorf56|CXorf56]]|-2.73|0.06|
|[[:human_genes:U:UBE2J1|UBE2J1]]|-2.52|0.06|
|[[:human_genes:S:SCYL1|SCYL1]]|-2.51|0.06|
|[[:human_genes:W:WDR83|WDR83]]|-2.47|0.06|
|[[:human_genes:C:CHKA|CHKA]]|-2.47|0.06|
|[[:human_genes:K:KDSR|KDSR]]|-2.46|0.06|
|[[:human_genes:P:PRKAA1|PRKAA1]]|-2.37|0.09|
|[[:human_genes:D:DOT1L|DOT1L]]|-2.30|0.24|
|[[:human_genes:O:OR51A7|OR51A7]]|-2.19|0.23|
|[[:human_genes:S:SCN8A|SCN8A]]|-2.15|0.36|
|[[:human_genes:H:HSPA13|HSPA13]]|-2.13|0.36|
|[[:human_genes:X:XPOT|XPOT]]|-2.09|0.34|
|[[:human_genes:F:FLVCR1|FLVCR1]]|-2.08|0.34|
|[[:human_genes:V:VAPA|VAPA]]|-2.06|0.35|
|[[:human_genes:G:GEN1|GEN1]]|-2.02|0.36|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-2.01|0.36|
|[[:human_genes:P:PPP2R2A|PPP2R2A]]|-2.00|0.36|
|[[:human_genes:P:P4HTM|P4HTM]]|-1.98|0.37|
|[[:human_genes:V:VEZT|VEZT]]|-1.97|0.37|
|[[:human_genes:T:TMEM106B|TMEM106B]]|-1.97|0.37|
|[[:human_genes:P:PPT2|PPT2]]|-1.96|0.45|
|[[:human_genes:R:RBMX2|RBMX2]]|-1.96|0.45|
|[[:human_genes:M:MBNL1|MBNL1]]|-1.95|0.38|
|[[:human_genes:P:PARL|PARL]]|-1.95|0.45|
|[[:human_genes:U:UHRF1|UHRF1]]|-1.95|0.45|
|[[:human_genes:Z:ZRANB2|ZRANB2]]|-1.94|0.38|
|[[:human_genes:Z:ZNF391|ZNF391]]|-1.94|0.38|
|[[:human_genes:P:PFN1|PFN1]]|-1.93|0.39|
|[[:human_genes:A:ARGLU1|ARGLU1]]|1.98|0.52|
|[[:human_genes:P:POMC|POMC]]|1.99|0.52|
|[[:human_genes:R:RBM39|RBM39]]|2.00|0.75|
|[[:human_genes:N:NANS|NANS]]|2.02|0.36|
|[[:human_genes:N:NOL8|NOL8]]|2.03|0.36|
|[[:human_genes:P:PQLC2|PQLC2]]|2.06|0.41|
|[[:human_genes:C:CUL9|CUL9]]|2.08|0.40|
|[[:human_genes:F:FCF1|FCF1]]|2.09|0.45|
|[[:human_genes:P:PAFAH1B1|PAFAH1B1]]|2.10|0.71|
|[[:human_genes:C:CDC27|CDC27]]|2.11|0.68|
|[[:human_genes:T:TOP1MT|TOP1MT]]|2.15|0.27|
|[[:human_genes:K:KRTAP9-7|KRTAP9-7]]|2.16|0.36|
|[[:human_genes:F:FBXO5|FBXO5]]|2.22|0.31|
|[[:human_genes:E:EIF4A1|EIF4A1]]|2.22|0.31|
|[[:human_genes:O:ORMDL2|ORMDL2]]|2.23|0.23|
|[[:human_genes:J:JAKMIP3|JAKMIP3]]|2.24|0.23|
|[[:human_genes:N:NOP16|NOP16]]|2.25|0.57|
|[[:human_genes:T:TRIM23|TRIM23]]|2.26|0.23|
|[[:human_genes:G:GPIHBP1|GPIHBP1]]|2.27|0.27|
|[[:human_genes:A:ALAD|ALAD]]|2.29|0.27|
|[[:human_genes:P:PLBD1|PLBD1]]|2.30|0.23|
|[[:human_genes:W:WDR46|WDR46]]|2.31|0.36|
|[[:human_genes:P:PRPF19|PRPF19]]|2.38|0.40|
|[[:human_genes:T:TAGLN|TAGLN]]|2.39|0.23|
|[[:human_genes:N:NOL9|NOL9]]|2.39|0.40|
|[[:human_genes:T:TFG|TFG]]|2.49|0.23|
|[[:human_genes:S:SPOP|SPOP]]|2.54|0.23|
|[[:human_genes:N:NUP160|NUP160]]|2.82|0.23|
|[[:human_genes:C:COPE|COPE]]|2.86|0.54|
|[[:human_genes:T:TRIM52|TRIM52]]|2.95|0.23|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp180|Dynasore 10μM R04 exp180]]|0.062|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|0.056|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp124|GSK343 3μM R03 exp124]]|0.056|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|0.052|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|0.051|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|0.06|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.052|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|0.052|<button type="primary" size="small" modal="8">View</button>|
</modal>


<modal id="1" size="lg" title="Cyclosporin-A 3μM R07 exp348  vs  Dynasore 10μM R04 exp180">
{{:chemogenomics:comparison_plots:exp180_vs_exp348.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Cyclosporin-A 3μM R07 exp348  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp348_vs_exp422.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Cyclosporin-A 3μM R07 exp348  vs  GSK343 3μM R03 exp124">
{{:chemogenomics:comparison_plots:exp124_vs_exp348.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Cyclosporin-A 3μM R07 exp348  vs  Ibrutinib 10μM R08 exp442">
{{:chemogenomics:comparison_plots:exp348_vs_exp442.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Cyclosporin-A 3μM R07 exp348  vs  Lapatinib 5μM R01 exp47">
{{:chemogenomics:comparison_plots:exp348_vs_exp47.png?nolink |}}
</modal>

<modal id="6" size="lg" title="BRD2 inhibitor II 20μM R07 exp341  vs  Cyclosporin-A 3μM R07 exp348">
{{:chemogenomics:comparison_plots:exp341_vs_exp348.png?nolink |}}
</modal>

<modal id="7" size="lg" title="BS-181 20μM R08 exp461  vs  Cyclosporin-A 3μM R07 exp348">
{{:chemogenomics:comparison_plots:exp348_vs_exp461.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  Cyclosporin-A 3μM R07 exp348">
{{:chemogenomics:comparison_plots:exp344_vs_exp348.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>